The survival motor neurons protein uses its ZPR for nuclear localization (original) (raw)
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Nature Cell Biology volume 3, pages E93–E94 (2001)Cite this article
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Spinal muscular atrophy is caused by mutations in the survival motor neurons gene, SMN1. The SMN protein localizes to both the cytoplasm and the nuclear bodies. One hallmark of spinal muscular atrophy is the failure of SMN to localize within these nuclear bodies. A recent study has identified a protein called ZPR1 that is required for nuclear translocation of SMN.
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Figure 1: Model of ZPR1 interaction with SMN.
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- Department of Genetics, Center for Human Genetics and Program in Cell Biology Case Western Reserve University and University Hospitals of Cleveland, Cleveland, 44106-4955, OH, USA
A. Gregory Matera & Michael D. Hebert
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- A. Gregory Matera
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Matera, A., Hebert, M. The survival motor neurons protein uses its ZPR for nuclear localization .Nat Cell Biol 3, E93–E94 (2001). https://doi.org/10.1038/35070157
- Issue Date: April 2001
- DOI: https://doi.org/10.1038/35070157