Park, C. C., Bissell, M. J. & Barcellos-Hoff, M. H. The influence of the microenvironment on the malignant phenotype. Mol. Med. Today6, 324–329 (2000). ArticleCASPubMed Google Scholar
Brown, L. F. et al. Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast. Clin. Cancer Res.5, 1041–1056 (1999). CASPubMed Google Scholar
Aboseif, S., El-Sakka, A., Young, P. & Cunha, G. Mesenchymal reprogramming of adult human epithelial differentiation. Differentiation65, 113–118 (1999). ArticleCASPubMed Google Scholar
Vaccariello, M., Javaherian, A., Wang, Y., Fusenig, N. E. & Garlick, J. A. Cell interactions control the fate of malignant keratinocytes in an organitypic model of early neoplasia. J. Invest. Dermatol.113, 384–391 (1999). ArticleCASPubMed Google Scholar
Fidler, I. Critical determinants of cancer metastasis: rationale for therapy. Cancer Chemother. Pharmacol.43, 3–10 (1999). Article Google Scholar
Nilsson, E. & Skinner, M. K. Cellular interactions that control primordial follicle development and folliculogenesis. J. Soc. Gynecol. Invest.8, S17–S20 (2001).
Li, Y., Liu, W., Hayward, S. W., Cunha, G. & Baskin, L. S. Plasticity of the urothelial phenotype: effects of gastro-intestinal mesenchyme/stroma and implications for urinary tract reconstruction. Differentiation66, 126–135 (2000). ArticleCASPubMed Google Scholar
Olumi, A. F. et al. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res.59, 5002–5011 (1999). CASPubMed Google Scholar
Liotta, L. A., Steeg, P. S. & Stetler-Stevension, W. G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell64, 327 (1991). ArticleCASPubMed Google Scholar
Kohn, E. C. & Liotta, L. A. Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res.55, 1856–1862 (1995). CASPubMed Google Scholar
Stromblad, S. & Cheresh, D. A. Integrins, angiogenesis and vascular cell survival. Chem. Biol.3, 881–885 (1996). ArticleCASPubMed Google Scholar
Carmeliet, P. & Jain, R. K. Angiogenesis in cancer and other diseases. Nature407, 249–2571 (2000). ArticleCASPubMed Google Scholar
Tomakidi, P. et al. Defects in the basement membrane and hemidesmisomes structure correlate with malignant phenotype and stromal interactions in HaCaT-Ras xenografts. Differentiation64, 263–275 (1999). ArticleCASPubMed Google Scholar
Guidi, A. J. et al. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast. Cancer80, 1945–1953 (1997). ArticleCASPubMed Google Scholar
Lee, A. H., Dublin, E. A. & Bobrow, L. G. Angiogenesis and expression of thymidine phosphorylase by inflammatory and carcinoma cells in ductal carcinoma in situ of the breast. J. Pathol.187, 285–290 (1999). ArticleCASPubMed Google Scholar
Gilead, A. & Neeman, M. Dynamic remodeling of the vascular bed precedes tumor growth: MLS ovarian carcinoma spheroids implanted in nude mice. Neoplasia1, 226–230 (1999). ArticleCASPubMedPubMed Central Google Scholar
Airola, K. & Fusenig, N. E. Differential stromal regulation of MMP-1 expression in benign and malignant keratinocytes. J. Invest. Dermatol.116, 85–92 (2000). Article Google Scholar
Mehdi, A. et al. Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nature Med.6, 100–106 (2000). ArticleCAS Google Scholar
Werb, Z. ECM and cell surface proteolysis: regulating cellular ecology. Cell91, 439–442 (1997). ArticleCASPubMed Google Scholar
Coussens, L. M., Tinkle, C. L., Hanahan, D. & Werb, Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell103, 481–490 (2000). ArticleCASPubMedPubMed Central Google Scholar
Bowden, E., Barth, M., Thomas, D., Glazer, R. & Mueller, S. An invasion related complex of cortactin, paxillin, and PKCμ associates with invadopodia at sites of extracellular matrix degradation. Oncogene18, 4440–4449 (1999). ArticleCASPubMed Google Scholar
Nakahara, H. et al. Transmembrane/cytoplasmic domain mediated membrane type 1-matrix metalloproteinase docking to invadopodia is required for cell invasion. Proc. Natl Acad. Sci. USA94, 7959–7964 (1997). ArticleADSCASPubMedPubMed Central Google Scholar
Hoegy, S., Oh, H.-R., Corcoran, M. & Stetler-Stevenson, W. Tissue inhibitor of metalloproteinases-2 (TIMP-2) suppresses TKR-growth factor signaling independent of metalloproteinase inhibition. J. Biol. Chem.276, 3203–3214 (2001). ArticleCASPubMed Google Scholar
Andreasen, P., Kioller, L., Christensen, L. & Duffy, M. The urokinase type plasminogen activator system in cancer metastasis: a review. Int. J. Cancer72, 1–22 (1997). ArticleCASPubMed Google Scholar
Fashena, S. & Thomas, S. M. Signaling by adhesion receptors. Nature Cell Biol.2, E225–E229 (2000). ArticleCASPubMed Google Scholar
Braga, V. The crossroads between cell-cell adhesion and motility. Nature Cell Biol.2, E182–E184 (2000). ArticleCASPubMed Google Scholar
Jo, M. et al. Cross talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells. J. Biol. Chem.275, 8806–8811 (2000). ArticleCASPubMed Google Scholar
Varner, J. A. & Cheresh, D. A. Integrins and cancer. Curr. Opin. Cell Biol.8, 724–730 (1996). ArticleCASPubMed Google Scholar
Roberts, A. B., McCune, B. K. & Sporn, M. B. TGF-β: regulation of extracellular matrix. Kidney Int.41, 557–559 (1992). ArticleCASPubMed Google Scholar
Varner, J. A., Brooks, P. C. & Cheresh, D. A. The integrin αvβ3: angiogenesis and apoptosis. Cell Adhes. Comm.3, 367–374 (1995). ArticleCAS Google Scholar
Fukai, F. et al. Release of biologically activities from quiescent fibronectin by conformational change and limited proteolysis by matrix metalloproteinases. Biochemistry34, 11453–11459 (1995). ArticleCASPubMed Google Scholar
Davis, G. E. Affinity of integrins for damaged extracellular matrix: alpha v beta 3 binds to denatured collagen type I through RGD sites. Biochem. Biophys. Res. Commun.182, 1025–1031 (1992). ArticleCASPubMed Google Scholar
Zlotnik, A. & Yoshie, O. Chemokines: a new classification system and their role in immunity. Immunity12, 121–127 (2000). ArticleCASPubMed Google Scholar
Muller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature410, 50–56 (2001). ArticleADSCASPubMed Google Scholar
Frisch, S. M., Vuori, K., Ruoslahti, E. & Chan-Hui, P. Y. Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol.134, 793–799 (1996). ArticleCASPubMed Google Scholar
Frisch, S. M. & Ruoslahti, E. Integrins and anoikis. Curr. Opin. Cell Biol.9, 701–706 (1997). ArticleCASPubMed Google Scholar
Cantley, L. & Pawson, T. Cell regulation. Curr. Opin. Cell Biol.13, 121–124 (2001). ArticleCAS Google Scholar
Dusko, I. et al. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature377, 539–544 (1995). Article Google Scholar
Xue, L., Murray, J. H. & Tolkovsky, A. M. The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons. J. Biol. Chem.275, 8817–8824 (2000). ArticleCASPubMed Google Scholar
Chen, H., Chan, P., Tang, M., Cheng, C. & Chang, T. Tyrosine phosphorylation of focal adhesion kinase stimulated by hepatocyte growth factor leads to mitogen-activated protein kinase activation. J. Biol. Chem.273, 25777–25782 (1998). ArticleCASPubMed Google Scholar
Totsukawa, G. et al. Distinct roles of ROCK and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. J. Cell Biol.150, 797–806 (2000). ArticleCASPubMedPubMed Central Google Scholar
Liotta, L. A. & Petricoin, E. F. Molecular profiling of human cancer. Nature Genet. Rev.1, 48–56 (2000). ArticleCAS Google Scholar
Paweletz, C. P. et al. Reverse phase protein microarrays which capture disease progression shown activation of pro-survival pathways at the cancer invasion front. Oncogene20, 1981–1989 (2001). ArticleCASPubMed Google Scholar
Gutheil, J. C. et al. Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin αvβ3 . Clin. Cancer Res.6, 3056–3061 (2000). CASPubMed Google Scholar
Masiero, L., Lapidos, K. A., Ambudkar, I. & Kohn, E. C. Regulation of the RhoA pathway in human endothelial cell spreading on type IV collagen: role of calcium influx. J. Cell. Sci.112, 3205–3213 (1999). ArticleCASPubMed Google Scholar
Weyant, M. J., Carothers, A. M., Bertangnolli, M. E. & Bertagnolli, M. M. Colon cancer chemopreventative drugs modulate integrin-mediated signaling pathways. Clin. Cancer Res.6, 949–956 (2000). CASPubMed Google Scholar
Brown, P. D. & Giavazzi, R. Matrix metalloproteinase inhibition: a review of anti-tumour activity. Annals Oncol.6, 967–974 (1995). ArticleCAS Google Scholar
Rowinsky, E. et al. Phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor BAY 12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies. J. Clin. Oncol.18, 178–186 (2000). ArticleCASPubMed Google Scholar
Brooks, P. C. et al. Anti-integrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J. Clin. Invest.96, 1815–1822 (1995). ArticleCASPubMedPubMed Central Google Scholar
Bonfoco, E., Chen, W., Paul, R., Cheresh, D. A. & Cooper, N. R. β1 integrin antagonism on adherent, differentiated human neuroblastoma cells triggers an apoptotic signaling pathway. Neuroscience101, 1145–1152 (2000). ArticleCASPubMed Google Scholar
Lode, H. N. et al. Synergy between an antiangiogenic integrin αv antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases. Proc. Natl Acad. Sci. USA96, 1591–1596 (1999). ArticleADSCASPubMedPubMed Central Google Scholar
Kohl, N. E. Farnesyltransferase inhibitors. Preclinical development. Ann. NY Acad. Sci.886, 91–102 (1999). ArticleADSCASPubMed Google Scholar
Sills, A. K. et al. Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature. Cancer Res.58, 2784–2792 (1998). CASPubMed Google Scholar
Kohn, E. C. et al. A phase I trial of carboxyamido-triazole and paclitaxel for relapsed solid tumors: potential efficacy of the combination, and demonstration of pharmacokinetic interaction. Clin. Cancer Res. (in the press).
Yuan, Z. Q. et al. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene19, 2324–2330 (2000). ArticleCASPubMed Google Scholar
Perrotte, P. et al. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin. Cancer Res.5, 257–265 (1999). CASPubMed Google Scholar
Iyer, S., Gurujeyalakshimi, G. & Giri, S. N. Effects of pirfenidone on transforming growth factor-β gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis. J. Pharmacol. Exp. Therapeut.291, 367–373 (1999). CAS Google Scholar
Fang, X. et al. Lysophospholipid growth factors in the initiation, progression, metastases and management of ovarian cancer. Ann. NY Acad. Sci.905, 188–208 (2000). ArticleADSCASPubMed Google Scholar
Shayesteh, L. et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nature Genet.21, 99–102 (1999). ArticleCASPubMed Google Scholar
Furui, T. et al. Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner. Clin. Cancer Res.5, 430–4318 (1999). Google Scholar