Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus (original) (raw)

References

  1. Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432 (1994); erratum ibid. 374, 479 (1995).
    Article ADS CAS PubMed Google Scholar
  2. Farooqi, I. S. et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N. Engl. J. Med. 341, 879–884 (1999).
    Article CAS PubMed Google Scholar
  3. Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R. & Burn, P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546–549 (1995).
    Article ADS CAS PubMed Google Scholar
  4. Kim, M. S. et al. The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J. Clin. Invest. 105, 1005–1011 (2000).
    Article CAS PubMed PubMed Central Google Scholar
  5. Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L. & Sivitz, W. I. Receptor-mediated regional sympathetic nerve activation by leptin. J. Clin. Invest. 100, 270–278 (1997).
    Article CAS PubMed PubMed Central Google Scholar
  6. Haynes, W. G., Morgan, D. A., Djalali, A., Sivitz, W. I. & Mark, A. L. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 33, 542–547 (1999).
    Article CAS PubMed Google Scholar
  7. Hakansson, M. L., Brown, H., Ghilardi, N., Skoda, R. C. & Meister, B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 18, 559–572 (1998).
    Article CAS PubMed PubMed Central Google Scholar
  8. Kalra, S. P. et al. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr. Rev. 20, 68–100 (1999).
    CAS PubMed Google Scholar
  9. Cone, R. D. The central melanocortin system and energy homeostasis. Trends Endocrinol. Metab. 10, 211–216 (1999).
    Article CAS PubMed Google Scholar
  10. Elias, C. F. et al. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23, 775–786 (1999).
    Article CAS PubMed Google Scholar
  11. Glaum, S. R. et al. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol. Pharmacol. 50, 230–235 (1996).
    CAS PubMed Google Scholar
  12. Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D. & Ashford, M. L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390, 521–525 (1997).
    Article ADS CAS PubMed Google Scholar
  13. Lee, K., Dixon, A. K., Richardson, P. J. & Pinnock, R. D. Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits. J. Physiol. (Lond.) 515, 439–452 (1999).
    Article CAS Google Scholar
  14. Shiraishi, T., Sasaki, K., Niijima, A. & Oomura, Y. Leptin effects on feeding-related hypothalamic and peripheral neuronal activities in normal and obese rats. Nutrition 15, 576–579 (1999).
    Article CAS PubMed Google Scholar
  15. Bagnol, D. et al. Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain. J. Neurosci. [online] (cited 25 Aug. 99) <http://www.jneurosci.org/cgi/content/full/19/18/RC26> (1999).
  16. Butler, A. A. et al. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141, 3518–3521 (2000).
    Article CAS PubMed Google Scholar
  17. Young, J. I. et al. Authentic cell-specific and developmentally regulated expression of pro-opiomelanocortin genomic fragments in hypothalamic and hindbrain neurons of transgenic mice. J. Neurosci. 18, 6631–6640 (1998).
    Article CAS PubMed PubMed Central Google Scholar
  18. Franklin, K. B. J. & Paxinos, G. The Mouse Brain in Stereotaxic Coordinates (Academic, San Diego, 1997).
    Google Scholar
  19. Kelly, M. J., Loose, M. D. & Ronnekleiv, O. K. Opioids hyperpolarize β-endorphin neurons via µ-receptor activation of a potassium conductance. Neuroendocrinology 52, 268–275 (1990).
    Article CAS PubMed Google Scholar
  20. Slugg, R. M., Hayward, M. D., Ronnekleiv, O. K., Low, M. J. & Kelly, M. J. Effect of the µ-opioid agonist DAMGO on medial basal hypothalamic neurons in β-endorphin knock-out mice. Neuroendocrinology 72, 208–217 (2000).
    Article CAS PubMed Google Scholar
  21. Powis, J. E., Bains, J. S. & Ferguson, A. V. Leptin depolarizes rat hypothalamic paraventricular nucleus neurons. Am. J. Physiol. 274, R1468–R1472 (1998).
    CAS PubMed Google Scholar
  22. Horvath, T. L., Bechmann, I., Naftolin, F., Kalra, S. P. & Leranth, C. Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res. 756, 283–286 (1997).
    Article CAS PubMed Google Scholar
  23. Broberger, C., Landry, M., Wong, H., Walsh, J. N. & Hokfelt, T. Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 66, 393–408 (1997).
    Article CAS PubMed Google Scholar
  24. King, P. J., Widdowson, P. S., Doods, H. N. & Williams, G. Regulation of neuropeptide Y release by neuropeptide Y receptor ligands and calcium channel antagonists in hypothalamic slices. J. Neurochem. 73, 641–646 (1999).
    Article CAS PubMed Google Scholar
  25. Grieco, P., Balse, P. M., Weinberg, D., MacNeil, T. & Hruby, V. J. d-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity. J. Med. Chem. 43, 4998–5002 (2000).
    Article CAS PubMed Google Scholar
  26. Csiffary, A., Gorcs, T. J. & Palkovits, M. Neuropeptide Y innervation of ACTH-immunoreactive neurons in the arcuate nucleus of rats: a correlated light and electron microscopic double immunolabeling study. Brain Res. 506, 215–222 (1990).
    Article CAS PubMed Google Scholar
  27. Horvath, T. L., Naftolin, F. & Leranth, C. GABAergic and catecholaminergic innervation of mediobasal hypothalamic beta-endorphin cells projecting to the medial preoptic area. Neuroscience 51, 391–399 (1992).
    Article CAS PubMed Google Scholar
  28. Cowley, M. A. et al. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24, 155–163 (1999).
    Article CAS PubMed Google Scholar
  29. Halaas, J. L. et al. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl Acad. Sci. USA 94, 8878–8883 (1997).
    Article ADS CAS PubMed PubMed Central Google Scholar

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