Extending the lifespan of long-lived mice (original) (raw)

Longevity

Nature volume 414, page 412 (2001) Cite this article

Abstract

Ames dwarf mice are mutant mice that live about 50% longer than their normal siblings1,2,3 because they carry a 'longevity' gene, _Prop1_df, and in some phenotypic respects they resemble normal mice whose lifespan has been extended by restricted food intake2,4,5. Here we investigate whether these factors influence lifespan by similar or independent mechanisms, by deliberately reducing the number of calories consumed by Ames dwarf mice. We show that calorie restriction confers a further lifespan increase in the dwarfs, indicating that the two factors may act through different pathways.

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Authors and Affiliations

  1. Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, 62901, Illinois, USA
    Andrzej Bartke & J. Chris Wright
  2. National Institute on Aging, NIH Animal Center, 16701 Elmer School Road, Poolesville, 20837, Maryland, USA
    Julie A. Mattison & Donald K. Ingram
  3. University of Michigan, 1500 East Medical Center Drive, Ann Arbor, 48109, Michigan, USA
    Richard A. Miller
  4. Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, 21224, Maryland, USA
    George S. Roth

Authors

  1. Andrzej Bartke
  2. J. Chris Wright
  3. Julie A. Mattison
  4. Donald K. Ingram
  5. Richard A. Miller
  6. George S. Roth

Corresponding author

Correspondence toAndrzej Bartke.

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Bartke, A., Wright, J., Mattison, J. et al. Extending the lifespan of long-lived mice.Nature 414, 412 (2001). https://doi.org/10.1038/35106646

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