On the complexity of self (original) (raw)
- Letter
- Published: 17 October 1991
- Satyajit Rath1 nAff2,
- Paula Preston-Hurlburt1,
- Donal B. Murphy1 nAff3 &
- …
- Charles A. Janeway Jr.1
Nature volume 353, pages 660–662 (1991)Cite this article
- 1464 Accesses
- 258 Citations
- 3 Altmetric
- Metrics details
Abstract
SELF peptides bound to self major histocompatibility complex (MHC) molecules have been implicated both in positive1,2 and in negative3,4 selection of T cells during intrathymic development. We report here that the novel MHC-restricted monoclonal antibody Y-A_e_ (ref. 5) detects the MHC class II bound form of a major self peptide6. Y-A_e_ binds ∼12% of the relevant MHC class II molecules on self antigen presenting cells. The peptide detected by Y-A_e_ is one of several major peptides eluted from the MHC molecule6. These data suggest that self peptides presented by self MHC class II molecules at densities sufficient to signal a CD4 T cell are of very limited complexity. Furthermore, as Y-A_e_ stains antigen presenting cells that mediate negative selection but not thymic cortical epithelial cells5 that drive positive selection3, differential expression of self peptide:self MHC class II complexes may be a key feature of intrathymic selection.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Nikolic-Zugic, J. & Bevan, M. J. Nature 344, 65–67 (1990).
Article ADS CAS Google Scholar - Berg, L., Frank, G. D. & Davis, M. M. Cell 60, 1043–1052 (1990).
Article CAS Google Scholar - vonBoehmer, H., Teh, H. S. & Kisielow, P. Immun. Today 10, 61–66 (1989).
Article Google Scholar - Murphy, K. M., Meimberger, A. B. & Loh, D. Y. Science 250, 1720–1723 (1990).
Article ADS CAS Google Scholar - Murphy, D. B. et al. Nature 338, 765–767 (1989).
Article ADS CAS Google Scholar - Rudensky, A. Y., Preston-Hurlburt, P., Hong, S.-C., Barlow, A. & Janeway, C. A. Jr Nature 353, 622–628.
- Demotz, S., Grey, H. M. & Sette, A. Science 249, 1028–1030 (1990).
Article ADS CAS Google Scholar - Harding, C. V. & Unanue, E. R. Nature 346, 574–576 (1990).
Article ADS CAS Google Scholar - Kappler, J., White, J., Wegmann, D., Mustain, E. & Marrack, P. Proc. natn. Acad. Sci. U.S.A. 79, 3604–3607 (1982).
Article ADS CAS Google Scholar - Janeway, C. A. Jr et al. J. Immun. 132, 662–669 (1984).
Google Scholar - Lerner, E. A. et al. J. exp. Med. 152, 1085–1101 (1980).
Article CAS Google Scholar
Author information
Author notes
- Satyajit Rath
Present address: National Institute of Immunology, JNU Complex, Shahid Jeet Singh Road, New Delhi, 110 067, India - Donal B. Murphy
Present address: Laboratory for Immunology, D421, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, New York, 12201, USA
Authors and Affiliations
- The Section of Immunobiology, Yale University School of Medicine and The Howard Hughes Medical Institute, New Haven, Connecticut, 06510, USA
Alexander Yu. Rudensky, Satyajit Rath, Paula Preston-Hurlburt, Donal B. Murphy & Charles A. Janeway Jr.
Authors
- Alexander Yu. Rudensky
You can also search for this author inPubMed Google Scholar - Satyajit Rath
You can also search for this author inPubMed Google Scholar - Paula Preston-Hurlburt
You can also search for this author inPubMed Google Scholar - Donal B. Murphy
You can also search for this author inPubMed Google Scholar - Charles A. Janeway Jr.
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Rudensky, A., Rath, S., Preston-Hurlburt, P. et al. On the complexity of self.Nature 353, 660–662 (1991). https://doi.org/10.1038/353660a0
- Received: 06 August 1991
- Accepted: 18 September 1991
- Issue Date: 17 October 1991
- DOI: https://doi.org/10.1038/353660a0