Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibody (original) (raw)

• Letter
• Published: 20 February 1992
• W. A. Schleif1,
• J. H. Nunberg1 nAff6,
• A. J. Conley1,
• Y. Eda2,
• S. Tokiyoshi2,
• S. D. Putney3 nAff7,
• S. Matsushrta4,
• K. E. Cobb5,
• C. M. Jett5,
• J. W. Eichberg5 nAff8 &
• …
• K. K. Murthy5

Nature volume 355, pages 728–730 (1992)Cite this article

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Abstract

THE acquired immunodeficiency syndrome (AIDS) is the late-stage clinical manifestation of long-term persistent infection with the human immunodeficiency virus type 1 (HIV-1). Immune responses directed against the virus and against virus-infected cells during the persistent infection fail to mediate resolution of the infection. As a result, a successful AIDS vaccine must elicit an immune state that will prevent the establishment of the persistent infection following introduction of the virus into the host. The third hyper-variable (V3) domain of the HIV-1 gp120 envelope glycoprotein is a disulphide-linked closed loop of about 30 amino acids which binds and elicits anti-HIV-1 type-specific virus-neutralizing antibodies1–7. The in vitro characteristics of anti-V3 domain antibody suggest that this antibody could by itself prevent HIV-1 infection _in vivo_8,9, an idea supported by chimpanzee challenge studies in which protection against the HIV-1 persistent infection seemed to correlate with the presence of anti-V3 domain antibody10–12. Here we directly demonstrate the protective efficacy of anti-V3 domain antibody in vivo and propose that this antibody is potentially useful as both a pre- and post-exposure prophylactic agent.

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Author notes

1. J. H. Nunberg
   Present address: Genentech Inc., South San Francisco, California, 94080, USA
2. S. D. Putney
   Present address: Alkermes Inc., Cambridge, Massachusetts, 02139, USA
3. J. W. Eichberg
   Present address: Wyeth-Ayerst Research, Philadelphia, Pennsyl-vania, 19087, USA

Authors and Affiliations

1. Merck, Sharp and Dohme Research Laboratories, West Point, Pennsylvania, 19486, USA
   E. A. Emini, W. A. Schleif, J. H. Nunberg & A. J. Conley
2. The Chemo-Sero-Therapeutic Research Institute, Kumamoto, 861-15, Japan
   Y. Eda & S. Tokiyoshi
3. Repligen Corporation, Cambridge, Massachusetts, 02139, USA
   S. D. Putney
4. Kumamoto University, Kumamoto, 860, Japan
   S. Matsushrta
5. Southwest Foundation for Biomedical Research, San Antonio, Texas, 78228, USA
   K. E. Cobb, C. M. Jett, J. W. Eichberg & K. K. Murthy

Authors

1. E. A. Emini
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2. W. A. Schleif
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3. J. H. Nunberg
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4. A. J. Conley
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5. Y. Eda
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6. S. Tokiyoshi
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7. S. D. Putney
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8. S. Matsushrta
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9. K. E. Cobb
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10. C. M. Jett
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11. J. W. Eichberg
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12. K. K. Murthy
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Emini, E., Schleif, W., Nunberg, J. et al. Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibody.Nature 355, 728–730 (1992). https://doi.org/10.1038/355728a0

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• Received: 08 October 1991
• Accepted: 21 November 1991
• Issue Date: 20 February 1992
• DOI: https://doi.org/10.1038/355728a0

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