Dispersion of neural progenitors within the germinal zones of the forebrain (original) (raw)

Nature volume 362, pages 636–638 (1993)Cite this article

An Erratum to this article was published on 20 May 1993

Abstract

ONE of the early events in the establishment of regional diversity in brain is the subdivision of the forebrain into the cerebral cortex1–7 and underlying basal ganglia8. This subdivision is of special interest, owing to the striking difference in cellular patterning in these two regions. Whereas the dorsal aspect of the telencephalon gives rise to the laminar, cortical regions of brain, the basal aspect gives rise to nuclear, subcortical regions. To examine early events in the regionalization of the forebrain, we visualized cell movement within the ventricular zones of the dorsal and basal regions of the E15 murine telencephalon. Over an 8–24-hour observation period, labelled cells moved extensively in the plane of the cortical ventricular zone. Cell dispersion was restricted, however, at the border between the cortical ventricular zone and the lateral ganglionic eminence, the basal telencephalic ventricular zone. We suggest that this restriction of cell movements establishes a regional pattern of neurogenesis in the developing brain.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Ramon Cajal, S. Histologie du Systeme Neneux de I'Homme et des Vertebres Vol. II (Maloine, Paris, 1911).
    Google Scholar
  2. Sauer, F. C. J. comp. Neurol. 63, 13–23 (1935).
    Article Google Scholar
  3. Sauer, M. E. & Chittenden, A. C. Proc. Soc. exp. Biot. Med. 101, 557–560 (1959).
    Article CAS Google Scholar
  4. Rakic, P. J. comp. Neurol. 141, 283–312 (1971).
    Article CAS Google Scholar
  5. Sidman, R. L. & Rakic, P. Brain Res. 62, 1–35 (1973).
    Article CAS Google Scholar
  6. Berry, M. & Rogers, A. W. J. Anat. 99, 691–709 (1965).
    CAS PubMed PubMed Central Google Scholar
  7. The Boulder Committee Anat Rec. 166, 257–262 (1970).
  8. Smart, I. H. M. & Sturrock, R. R. Ontogeny of the Neostriatum 23, 127–146 (1979).
    Article Google Scholar
  9. Honig, M. C. & Hume, R. I. Trends Neurosci. 12, 333–341 (1989).
    Article CAS Google Scholar
  10. Friederikson, K. & McKay, R. J. Neurosci. 58, 815–821 (1988).
    Google Scholar
  11. Mission, J.-P., Takahashi, R. & Caviness, V. S. Glia 4, 138–148 (1991).
    Article CAS Google Scholar
  12. Edmondson, J. C. & Hatten, M. E. J. Neurosci. 7, 1928–1934 (1987).
    Article CAS Google Scholar
  13. Godemont, P., Salaun, J. & Mason, C. A. Neuron 5, 173–186 (1990).
    Article Google Scholar
  14. Gruler, H. & Bultmann, B. D. Blood Cells 10, 61–77 (1984).
    CAS PubMed Google Scholar
  15. Walsh, C. & Cepko, C. L. Soc. Neurosci. Abstr. 18, 925 (1992).
    Google Scholar
  16. Luskin, M. B., Pearlman, A. L. & Sanes, J. R. Neuron 1, 635–647 (1988).
    Article CAS Google Scholar
  17. Price, J. & Thurlow, L. Development 104, 473–482 (1988).
    CAS PubMed Google Scholar
  18. Walsh, C. & Cepko, C. L. Science 241, 1342–1345 (1988).
    Article ADS CAS Google Scholar
  19. Walsh, C. & Cepko, C. L. Science 255, 434–440 (1992).
    Article ADS CAS Google Scholar
  20. Misson, J. P., Austin, C. P., Takahashi, T., Cepko, C. L. & Caviness, V. S. Cerebral Cortex 1, 221–234 (1991).
    Article CAS Google Scholar
  21. Gray, G. E. & Sanes, J. R. Neuron 6, 211–225 (1992).
    Article Google Scholar
  22. O'Rourke, N. A., Dailey, M. E., Smith, S. J. & McConnell, S. K. Science 258, 299–302 (1992).
    Article ADS CAS Google Scholar
  23. Porteus, M. H., Bulfone, A., Ciarnello, R. D. & Rubenstein, J. L. R. Neuron 7, 221–229 (1991).
    Article CAS Google Scholar
  24. Tao, W. & Lai, E. Neuron 8, 957–966 (1992).
    Article CAS Google Scholar
  25. Price, M., Lemaistre, M., Pischetola, M., Di Lauro, R. & Duboule, D. Nature 351, 748–751 (1991).
    Article ADS CAS Google Scholar
  26. Lo, L.-C. et al. Genes Dev. 5, 1524–1537 (1991).
    Article CAS Google Scholar
  27. Simeone, A. et al. Nature 358, 687–690 (1992).
    Article ADS CAS Google Scholar
  28. Fraser, S., Keynes, R. & Lumsden, A. Nature 344, 431–435 (1990).
    Article ADS CAS Google Scholar
  29. McGinnis, W. & Krumlauf, R. Cell 68, 283–302 (1992).
    Article CAS Google Scholar

Download references

Author information

Author notes

  1. Gord Fishell & Mary E. Hatten
    Present address: The Rockefeller University, 1230 York Avenue, New York, New York, 10021-6399, USA

Authors and Affiliations

  1. Department of Pathology, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York, 10032, USA
    Gord Fishell, Carol A. Mason & Mary E. Hatten

Authors

  1. Gord Fishell
    You can also search for this author inPubMed Google Scholar
  2. Carol A. Mason
    You can also search for this author inPubMed Google Scholar
  3. Mary E. Hatten
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Fishell, G., Mason, C. & Hatten, M. Dispersion of neural progenitors within the germinal zones of the forebrain.Nature 362, 636–638 (1993). https://doi.org/10.1038/362636a0

Download citation

This article is cited by