Feature-linked synchronization of thalamic relay cell firing induced by feedback from the visual cortex (original) (raw)

Nature volume 369, pages 479–482 (1994)Cite this article

Abstract

THE function of the massive feedback projection from visual cortex to its thalamic relay nucleus1,2 has so far eluded any clear overview. This feedback exerts a range of effects3–6, including an increase in the inhibition elicited by moving contours7,8, but the functional logic of the direct connections to the thalamic cells that relay the retinal input to the cortex9–11 remains largely unknown. In contrast to its thalamic nucleus, the visual cortex is characterized by cells that are strongly sensitive to the orientation of moving contours. Here we report that when driven by moving oriented visual stimuli the cortical feedback induces correlated firing in relay cells. This cortically induced correlation of relay cell activity produces coherent firing in those groups of relay cells with receptive field alignments appropriate to signalling the particular orientation of the moving contour to the cortex. Synchronization of relay cell firing means that they will elicit temporally overlapping excitatory postsynaptic potentials in their cortical target cells, thus increasing the chance that the cortical cells will fire. Effectively this increases the gain of the input for feature-linked events detected by the cortex. We propose that this feedback loop serves to lock or focus the appropriate circuitry onto the stimulus feature.

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References

  1. Robson, J. A. J. comp. Neurol. 216, 89–103 (1983).
    Article CAS Google Scholar
  2. Wilson, J. R., Friedlander, M. J. & Sherman, S. M. Proc. R. Soc. 221, 411–436 (1984).
    ADS CAS Google Scholar
  3. Tsumoto, T., Creutzfeldt, O. D. & Legendy, C. R. Brain Res. 345, 364 (1978).
    Google Scholar
  4. Marrocco, R. T. & McClurkin, J. W. Expl Brain Res. 59, 50–56 (1985).
    Article CAS Google Scholar
  5. Varela, F. J. & Singer, W. Expl Brain Res. 66, 10–20 (1987).
    Article CAS Google Scholar
  6. Lindstrom, S. & Wróbei, A. Expl Brain Res. 79, 313–318 (1990).
    Article CAS Google Scholar
  7. Murphy, P. C. & Sillito, A. M. Nature 329, 727–729 (1987).
    Article ADS CAS Google Scholar
  8. Sillito, A. M., Cudeiro, J & Murphy, P. C. Expl Brain Res. 93, 6–16 (1993).
    Article CAS Google Scholar
  9. Ahlsen, G., Grant, K. & Lindstrom, S. Brain Res. 234, 454–458 (1982).
    Article CAS Google Scholar
  10. Weber, A. J., Kalil, R. E. & Behan, M. J. comp. Neurol. 289, 156–164 (1989).
    Article CAS Google Scholar
  11. Montero, V. M. Expl Brain Res. 86, 257–270 (1991).
    Article CAS Google Scholar
  12. Ts'o D. Y., Gilbert, C. D. & Wiesel, T. N. J. Neurosci. 6, 1160–1170 (1986).
    Article CAS Google Scholar
  13. Gray, C. M., Konig, P., Engel, A. K. & Singer, W. Nature 338, 334–337 (1989).
    Article ADS CAS Google Scholar
  14. Engel, A. K., König, P., Gray, C. M. & Singer, W. Eur. J. Neurosci. 2, 588–606 (1990).
    Article Google Scholar
  15. Gray, C. M., Engel, A. K., König, P. & Singer, W. Eur. J. Neurosci. 2, 607–619 (1990).
    Article Google Scholar
  16. Sillito, A. M. in Mechanisms of GABA Action in the Visual System (eds Mize, R. R., Marc, R. & Sillito, A. M.) 349–384 (Elsevier, Amsterdam, 1992).
    Google Scholar
  17. Hubel D. H. & Wiesel T. N. J. Physiol. 160, 106–154 (1962).
    Article CAS Google Scholar
  18. Abeles, M J. Neurosci. Meth. 5, 317–325 (1982).
    Article CAS Google Scholar
  19. Abeles, M. & Gerstein, G. L. J. Neurophysiol. 60, 909–924 (1988).
    Article CAS Google Scholar
  20. Palm, G., Aertsen, A. M. H. J. & Gerstein, G. L. Biol. Cybern. 59, 1–11 (1988).
    Article CAS Google Scholar
  21. Aertsen, A. M. H. J. et al. J. Neurophysiol. 61, 900–917 (1989).
    Article CAS Google Scholar

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Author notes

  1. George L. Gerstein: Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

Authors and Affiliations

  1. Department of Visual Science, Institute of Ophthalmology, Bath Street, London, EC1V 9EL, UK
    Adam M. Sillito, Helen E. Jones, George L. Gerstein & David C. West

Authors

  1. Adam M. Sillito
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  2. Helen E. Jones
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  3. George L. Gerstein
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  4. David C. West
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Sillito, A., Jones, H., Gerstein, G. et al. Feature-linked synchronization of thalamic relay cell firing induced by feedback from the visual cortex.Nature 369, 479–482 (1994). https://doi.org/10.1038/369479a0

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