Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection (original) (raw)

• Article
• Published: 12 January 1995
• Avidan U. Neumann1 na1 na2,
• Alan S. Perelson1 na2,
• Wen Chen1,
• John M. Leonard1 na3 &
• …
• Martin Markowitz1

Nature volume 373, pages 123–126 (1995)Cite this article

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Abstract

Treatment of infected patients with ABT-538, an inhibitor of the protease of human immuno-deficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 ±0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.

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References

1. Weiss, R. A. Science 260, 1273–1279 (1993).
   Article ADS CAS PubMed Google Scholar
2. Ho, D. D., Moudgil, T. & Alam, M. New Engl. J. Med. 321, 1621–1625 (1989).
   Article CAS PubMed Google Scholar
3. Simmonds, P. et al. J. Virol. 64, 864–872 (1990).
   CAS PubMed PubMed Central Google Scholar
4. Connor, R. I., Mohri, H., Cao, Y. & Ho, D. D. J. Virol. 67, 1772–1777 (1993).
   CAS PubMed PubMed Central Google Scholar
5. Patterson, B. K. et al. Science 260, 976–979 (1993).
   Article ADS CAS PubMed Google Scholar
6. Piatak, M. et al. Science 259, 1749–1754 (1993).
   Article ADS CAS PubMed Google Scholar
7. Pantaleo, G. et al. Nature 362, 355–359 (1993).
   Article ADS CAS PubMed Google Scholar
8. Embretson, J. et al. Nature 362, 359–362 (1993).
   Article ADS CAS PubMed Google Scholar
9. Wain-Hobson, S. Nature 366, 22 (1993).
   Article ADS CAS PubMed Google Scholar
10. Kempf, D. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
11. Markowitz, M. et al. J. Virol. (in the press).
12. Pachi, C. et al. J. AIDS (in the press).
13. Cao, Y. et al. AIDS Res. Human Retroviruses (in the press).
14. Perelson, A. S., Kirschner, D. E. & De Boer, R. J. Math. Biosci. 114, 81–125 (1993).
    Article CAS Google Scholar
15. Grody, W. W., Fligiel, S. & Naeim, F. Am. J. clin. Path. 84, 85–95 (1985).
    Article CAS PubMed Google Scholar
16. Paul, W. E. Fundamental Immunology (Raven, New York, 1985).
    Google Scholar
17. Haase, A. T. Ann. N. Y. Acad. Sci. 724, 75–86 (1994).
    Article ADS CAS PubMed Google Scholar
18. Ameisen, J. C. & Capron, A. Immun. Today 12, 102–105 (1991).
    Article CAS PubMed Google Scholar
19. Wain-Hobson, S. Curr. Opin. Genet. Dev. 3, 878–883 (1993).
    Article CAS PubMed Google Scholar
20. Coffin, J. M. Curr. Top. Microbiol. Immun. 176, 143–164 (1992).
    CAS Google Scholar

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Author notes

1. Avidan U. Neumann: Santa Fe Institute, Santa Fe, New Mexico 87501, USA
2. Avidan U. Neumann and Alan S. Perelson: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
3. John M. Leonard: Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA

Authors and Affiliations

1. Aaron Diamond AIDS Research Center, NYU School of Medicine, 455 First Avenue, New York, New York, 10016, USA
   David D. Ho, Avidan U. Neumann, Alan S. Perelson, Wen Chen, John M. Leonard & Martin Markowitz

Authors

1. David D. Ho
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2. Avidan U. Neumann
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3. Alan S. Perelson
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4. Wen Chen
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5. John M. Leonard
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6. Martin Markowitz
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Ho, D., Neumann, A., Perelson, A. et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection.Nature 373, 123–126 (1995). https://doi.org/10.1038/373123a0

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• Received: 16 November 1994
• Accepted: 15 December 1994
• Issue Date: 12 January 1995
• DOI: https://doi.org/10.1038/373123a0