Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120 (original) (raw)

Nature volume 375, pages 497–500 (1995)Cite this article

Abstract

THE depletion of CD4+ T cells in AIDS is correlated with high turnover of the human immunodeficiency virus HIV-1,2 and associated with apoptosis3-5. The molecular mechanism of apoptosis in HIV infection, however, is largely unknown. T-cell apoptosis might be affected by viral proteins such as HIV-1 Tat6-9 and gp120 (refs 10, 11). T-cell-receptor (TCR)-induced apoptosis was recently shown to involve the CD95 (APO-1/Fas) receptor12. We show here that HIV-1 Tat strongly sensitizes TCR- and CD4(gpl20)-induced apoptosis by upregulation of CD95 ligand expression. Concentrations of Tat found to be effective in cultures of HIV-1-infected cells were also observed in sera from HIV-1-infected individuals. Taken together, our results indicate that HIV-1 Tat and gp!20 accelerate CD95-mediated, activation-induced T-cell apoptosis, a mechanism that may contribute to CD4+T-cell depletion5,13,14 in AIDS.

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Authors and Affiliations

  1. Tumorimmunology Program, German Cancer Research Centre, D-69120, Heidelberg, Germany
    Michael O. Westendorp, Kirstin Stricker, Jens Dhein, Henning Walczak & Peter H. Krammer
  2. Applied Tumor Virology, German Cancer Research Centre, D-69120, Heidelberg, Germany
    Christina Ochsenbauer
  3. Centre of Molecular Biology, University of Heidelberg, 6900, Heidelberg, Germany
    Rainer Frank
  4. Children's Hospital, University of Heidelberg, 6900, Heidelberg, Germany
    Klaus-Michael Debating

Authors

  1. Michael O. Westendorp
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  2. Rainer Frank
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  3. Christina Ochsenbauer
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  4. Kirstin Stricker
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  5. Jens Dhein
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  6. Henning Walczak
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  7. Klaus-Michael Debating
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  8. Peter H. Krammer
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Westendorp, M., Frank, R., Ochsenbauer, C. et al. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.Nature 375, 497–500 (1995). https://doi.org/10.1038/375497a0

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