Antiproliferative action of interferon-α requires components of T-cell-receptor signalling (original) (raw)

Nature volume 390, pages 629–632 (1997)Cite this article

Abstract

Signal transduction through both cytokine and lymphocyte antigen receptors shares some common pathways by which they initiate cellular responses, such as activation of mitogen-activated protein kinase(s)1,2. However, other signalling components appear to be uniquely coupled to each receptor. For example, the interferon receptors transduce regulatory signals through the JAK/STAT pathway, resulting in an inhibition of growth and of antiviral effects, whereas this pathway apparently plays no role in T-cell-receptor (TCR)-dependent gene expression3,4. Conversely, signal transduction through the TCR requires the tyrosine kinases Lck and ZAP-70 and the tyrosine phosphatase CD45 (ref. 5). Here we show that, unexpectedly, transmission of growth-inhibitory signals by interferon-α (IFN-α) in T cells requires the expression and association of CD45, Lck and ZAP-70 with the IFN-α-receptor signalling complex.

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Acknowledgements

We thank S. Goelz and C. Benjamin for antibodies against IFNaR1.

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Author notes

  1. Andrew C. Larner
    Present address: Department of Medicine and Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, 94143, California, USA
  2. Ana Gamero
    Present address: Department of Immunology, Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, 44195, USA

Authors and Affiliations

  1. Center for Biologics, Evaluation and Research, FDA, Bethesda, 20892, Maryland, USA
    Emanuel F. Petricoin III, Satoshi Ito, Susette Audet, Louis F. Stancato, Kathleen Clouse, Judy Beeler, David S. Finbloom, Elizabeth W. Shores & Andrew C. Larner
  2. Department of Immunology and Pharmacology, Mayo Clinic, Rochester, 55905, Minnesota, USA
    Brandi L. Williams & Robert Abraham
  3. Department of Pathology, USUHS, Jones Bridge Rd, Bethesda, 20892, Maryland, USA
    Philip Grimley
  4. Department of Medicine and Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, 94143, California, USA
    Arthur Weiss

Authors

  1. Emanuel F. Petricoin III
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  2. Satoshi Ito
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  3. Brandi L. Williams
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  4. Susette Audet
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  5. Louis F. Stancato
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  6. Ana Gamero
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  7. Kathleen Clouse
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  8. Philip Grimley
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  9. Arthur Weiss
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  10. Judy Beeler
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  11. David S. Finbloom
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  12. Elizabeth W. Shores
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  13. Robert Abraham
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  14. Andrew C. Larner
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Corresponding author

Correspondence toAndrew C. Larner.

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Petricoin, E., Ito, S., Williams, B. et al. Antiproliferative action of interferon-α requires components of T-cell-receptor signalling.Nature 390, 629–632 (1997). https://doi.org/10.1038/37648

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