Dissociation in prefrontal cortex of affective and attentional shifts (original) (raw)

Nature volume 380, pages 69–72 (1996)Cite this article

Abstract

THE prefrontal cortex is implicated in such human characteristics as volition, planning, abstract reasoning and affect1–6. Frontal-lobe damage can cause disinhibition such that the behaviour of a subject is guided by previously acquired responses that are inappropriate to the current situation7–9. Here we demonstrate that disinhibition, or a loss of inhibitory control, can be selective for particular cognitive functions and that different regions of the prefrontal cortex provide inhibitory control in different aspects of cognitive processing. Thus, whereas damage to the lateral prefrontal cortex (Brodmann's area 9) in monkeys causes a loss of inhibitory control in attentional selection, damage to the orbito-frontal cortex in monkeys causes a loss of inhibitory control in 'affective' processing, thereby impairing the ability to alter behaviour in response to fluctuations in the emotional significance of stimuli. These findings not only support the view that the prefrontal cortex has multiple functions, but also provide evidence for the distribution of different cognitive functions within specific regions of prefrontal cortex.

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Author notes

  1. A. C. Roberts
    Present address: Dept of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
  2. A. C. Roberts: To whom correspondence should be addressed at the Department of Anatomy.

Authors and Affiliations

  1. Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    R. Dias, T. W. Robbins & A. C. Roberts

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  1. R. Dias
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  2. T. W. Robbins
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  3. A. C. Roberts
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Dias, R., Robbins, T. & Roberts, A. Dissociation in prefrontal cortex of affective and attentional shifts.Nature 380, 69–72 (1996). https://doi.org/10.1038/380069a0

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