S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control (original) (raw)

Nature volume 380, pages 221–226 (1996)Cite this article

Abstract

A dynamic cycle exists in which haemoglobin is S-nitrosylated in the lung when red blood cells are oxygenated, and the NO group is released during arterial–venous transit. The vasoactivity of S-nitrosohaemoglobin is promoted by the erythrocytic export of S-nitrosothiols. These findings highlight newly discovered allosteric and electronic properties of haemoglobin that appear to be involved in the control of blood pressure and which may facilitate efficient delivery of oxygen to tissues. The role of S-nitrosohaemoglobin in the transduction of NO-related activities may have therapeutic applications.

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References

  1. Lancaster, J. R. Proc. natn. Acad. Sci. U.S.A. 91, 8137–8141 (1994).
    Article ADS CAS Google Scholar
  2. Wood, J. & Garthwaite, J. Neuropharmacology 33, 1235–1244 (1994).
    Article CAS Google Scholar
  3. Gaston, B. et al. Proc. natn. Acad. Sci. U.S.A. 90, 10957–10961 (1993).
    Article ADS CAS Google Scholar
  4. Stamler, J. S. et al. Proc. natn. Acad. Sci. U.S.A. 89, 444–448 (1992).
    Article ADS CAS Google Scholar
  5. DeGroote, M. A. et al. Proc. natn. Acad. Sci. U.S.A. 92, 6399–6403 (1995).
    Article ADS CAS Google Scholar
  6. Stamler, J. C. Cell 78, 931–936 (1994).
    Article CAS Google Scholar
  7. Olson, J. S. Meth. Enzym. 76, 631–651 (1981).
    Article CAS Google Scholar
  8. Antonini, E. & Brunori, M. in Hemoglobin and Myoglobin in their Reactions with Ligands 29–31 (Elsevier, New York, 1971).
    Google Scholar
  9. Scharfstein, J. S. et al. J. clin. Invest. 94, 1432–1439 (1995).
    Article Google Scholar
  10. Clancy, R. M. et al. Proc. natn. Acad. Sci. U.S.A. 91, 3680–3684 (1994).
    Article ADS CAS Google Scholar
  11. Toothill, C. Brit. J. Anaesth. 39, 405–412 (1967).
    Article CAS Google Scholar
  12. Garel, C. et al. J. Biochem. 123, 513–519 (1982).
    CAS Google Scholar
  13. Jocelyn, P. C. Biochemistry of the SH Group 243 (Academic, London, 1972).
    Google Scholar
  14. Craescu, C. T. et al. J. biol. Chem. 261, 14710–14716 (1986).
    CAS PubMed Google Scholar
  15. Wennmalm, A., Benthin, G. & Petersson, A. S. Br. J. Pharmac. 106(3), 507–508 (1992).
    Article CAS Google Scholar
  16. Arnelle, D. R. & Stamler, J. S. Arch. Biochem. Biophys. 318, 279–285 (1995).
    Article CAS Google Scholar
  17. Vogel, W. M. et al. Am. J. Physiol. 251, H413–H420 (1986).
    ADS CAS PubMed Google Scholar
  18. Olsen, S. B. et al. Circulation 93, 329–332 (1996).
    Article Google Scholar
  19. Stamler, J. S. et al. Proc. natn. Acad. Sci. U.S.A. 89, 7674–7677 (1992).
    Article ADS CAS Google Scholar
  20. Kondo, T., Dale, G. L. & Beutler, E. Meth. Enzym. 252, 72–83 (1995).
    Article CAS Google Scholar
  21. Bolotina, V. M. et al. Nature 368, 850–853 (1994).
    Article ADS CAS Google Scholar
  22. Salhany, J. M. & Gaines, K. C. Trends biochem. Sci. Jan, 1–3 (1981).
  23. Mansouri, A. Biochem. biophys. Res. Commun. 89, 441–447 (1979).
    Article CAS Google Scholar
  24. Kilbourn, R. G. et al. Biochem. biophys. Res. Commun. 199, 155–162 (1994).
    Article CAS Google Scholar
  25. Beckman, J. S., Wink, D. & Crow, J. P. in Methods in Nitric Oxide Research (eds Feelisch, M. & Stamler, J. S.) (Wiley, Chichester, UK, 1996).
    Google Scholar
  26. Shen, W., Hintze, T. H. & Wolin, M. S. Circulation 92, 3505–3512 (1995).
    Article CAS Google Scholar

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Authors and Affiliations

  1. Department of Medicine, Divisions of Respiratory and Cardiovascular Medicine, Duke University Medical Center, MSRB Building, Room 321, Box 2612, Durham, North Carolina, 27710, USA
    Li Jia & Jonathan S. Stamler
  2. Department of Cell Biology, Duke University Medical Center, MSRB Building, Room 321, Box 2612, Durham, North Carolina, 27710, USA
    Celia Bonaventura, Joseph Bonaventura & Jonathan S. Stamler
  3. Nicholas School of the Environment, Duke Marine Biomedical Center, Rivers Island, North Carolina, 28516, USA
    Celia Bonaventura & Joseph Bonaventura

Authors

  1. Li Jia
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  2. Celia Bonaventura
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  3. Joseph Bonaventura
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  4. Jonathan S. Stamler
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Jia, L., Bonaventura, C., Bonaventura, J. et al. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control.Nature 380, 221–226 (1996). https://doi.org/10.1038/380221a0

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