The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells (original) (raw)

References

1. Spriggs, M. K. One step ahead of the game: Viral immunomodulatory molecules. Annu. Rev. Immunol. 14, 101–130 (1996).
   Article CAS PubMed Google Scholar
2. Ljunggren, H.-G. & Karre, K. In search of the ‘missing self’: MHC molecules and NK recognition. Immunol. Today 11, 237–242 (1990).
   Article CAS PubMed Google Scholar
3. Beersma, M. F. C., Bijlmakers, M. J. E. & Ploegh, H. L. Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains. J. Immunol. 151, 4455–4464 (1993).
   CAS PubMed Google Scholar
4. Jones, T. R. et al. Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains. J. Virol. 69, 4830–4841 (1995).
   CAS PubMed PubMed Central Google Scholar
5. Wiertz, E. J. H. J. et al. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell 84, 769–779 (1996).
   Article CAS PubMed Google Scholar
6. Wiertz, E. J. H. J. et al. Cytosolic destruction of a type I membrane protein by transfer via the Sec61p complex from the ER to the proteasome. Nature 384, 432–438 (1996).
   Article ADS CAS PubMed Google Scholar
7. Ahn, K. et al. Human cytomegalovirus inhibits antigen presentation by a sequential multistep process. Proc. Natl Acad. Sci. USA 93, 10990–10995 (1996).
   Article ADS CAS PubMed PubMed Central Google Scholar
8. Jones, T. R. et al. Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. Proc. Natl Acad. Sci. USA 93, 11327–11333 (1996).
   Article ADS CAS PubMed PubMed Central Google Scholar
9. Hengel, H., Flohr, T., Hammerling, G. J. & Koszinowski, U. H. Human cytomegalovirus inhibits peptide translocation into the endoplasmic reticulum for MHC class I assembly. J. Gen. Virol. 77, 2287–2296 (1996).
   Article CAS PubMed Google Scholar
10. Beck, S. & Barrell, B. G. Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. Nature 331, 269–272 (1988).
    Article ADS CAS PubMed Google Scholar
11. Browne, H., Smith, G., Beck, S. & Minson, A. A complex between the MHC class I homologue encoded by human cytomegalovirus and β2-microglobulin. Nature 347, 770–772 (1990).
    Article ADS CAS PubMed Google Scholar
12. Fahnestock, M. L. et al. The MHC class I homologue encoded by human cytomegalovirus binds endogenous peptides. Immunity 3, 583–590 (1995).
    Article CAS PubMed Google Scholar
13. Wiley, D. MHC gene in cytomegalovirus. Nature 331, 209–210 (1988).
    Article ADS CAS PubMed Google Scholar
14. Shimizu, Y. & DeMars, R. Production of human cells expressing individual transfered HLA-A, -B, -C genes using an HLA-A, -B, -C null human cell line. J. Immunol. 142, 3320 (1989).
    CAS PubMed Google Scholar
15. Parham, P., Androlewicz, M. J., Holmes, N. J. & Rothenberg, B. E. Arginine-45 is a major part of the determinant of human β2-microglobulin recognised by mouse monoclonal antibody BBM.1. J. Biol. Chem. 258, 6179–6186 (1983).
    CAS PubMed Google Scholar
16. Brocker, T., Peter, A., Traunecker, A. & Karjaleinen, K. New simplified molecular design for functional T cell receptor. Eur. J. Immunol. 23, 1435–1439 (1993).
    Article CAS PubMed Google Scholar
17. Fuhrmann, U., Bause, E. & Ploegh, H. Inhibitors of oligosaccharide processing. Biochim. Biophys. Acta 825, 95–110 (1985).
    Article CAS PubMed Google Scholar
18. Aramburu, J. et al. A novel functional cell surface dimer (Kp43) expressed by natural killer cells and T cell receptor-g/d+ T lymphocytes. I. Inhibition of the IL-2 dependent proliferation by anti-Kp43 monoclonal antibody. J. Immunol. 144, 3238–3247 (1990).
    CAS PubMed Google Scholar
19. Aramburu, J., Balboa, M. A., Izquierdo, M. & Lopez-botet, M. A novel functional cell surface dimer (Kp43) expressed by natural killer cells and T cell receptor-g/d+ T lymphocytes. II. Modulation of natural killer cell cytoxocity by anti-Kp43 monoclonal antibody. J. Immunol. 147, 714–721 (1991).
    CAS PubMed Google Scholar
20. Perez-Villar, J. J. et al. Functional ambivalence of the Kp43 (CD94) NK cell associated surface antigen. J. Immunol. 154, 5779–5788 (1995).
    CAS PubMed Google Scholar
21. Phillips, J. H. et al. CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B and HLA-C allotypes. Immunity 5, 163–172 (1996).
    Article CAS PubMed Google Scholar
22. Perez-Villar, J. J. et al. Biochemical and serologic evidence for the existence of functionally distinct forms of the CD94 NK cell receptor. J. Immunol. 157, 5367–5374 (1996).
    CAS PubMed Google Scholar
23. Lazetic, S., Chang, C., Houchins, J. P., Lanier, L. L. & Phillips, J. H. Human natural killer cell receptors involved in MHC class I recognition are disulfide linked heterodimers of CD94 and NKG2 subunits. J. Immunol. 157, 4741–4745 (1996).
    CAS PubMed Google Scholar
24. McGeoch, D. J., Cook, S., Dolan, A., Jamieson, F. E. & Telford, E. A. Molecular phylogeny and evolutionary timescale for the family of mammalian herpesviruses. J. Mol. Biol. 247, 443–458 (1995).
    Article CAS PubMed Google Scholar
25. Mandelboim, O. et al. Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules. J. Exp. Med. 184, 913–922 (1996).
    Article CAS PubMed Google Scholar
26. Shimizu, Y., Geraghy, D. E., Koller, B. H., Orr, H. T. & DeMars, R. Transfer and expression of three cloned human non-HLA-A, B, C class I major histocompatibility genes in mutant lymphoblastoid cells. Proc. Natl Acad. Sci. USA 85, 227–231 (1988).
    Article ADS CAS PubMed PubMed Central Google Scholar

Download references