Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F (original) (raw)
References
Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell81, 323–330 (1995). ArticleCAS Google Scholar
Sherr, C. J. & Roberts, J. M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev.9, 1149–1163 (1995). ArticleCAS Google Scholar
Eisenman, R. N. & Cooper, J. A. Signal transduction: Beating a path to Myc. Nature378, 438–439 (1995). ArticleADSCAS Google Scholar
Mulcahy, L. S., Smith, M. R. & Stacey, D. W. Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature313, 241–243 (1985). ArticleADSCAS Google Scholar
Lowry, D. R. & Willumsen, B. M. Function and regulation of ras. Annu. Rev. Biochem.62, 851–891 (1993). Article Google Scholar
Feig, L. A. & Cooper, G. M. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol.8, 3235–3243 (1988). ArticleCAS Google Scholar
Land, H., Parada, L. F. & Weinberg, R. A. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature304, 596–602 (1982). ArticleADS Google Scholar
Kohl, N. E. & Ruley, H. E. Role of c-myc in the transformation of REF52 cells by viral and cellular oncogenes. Oncogene2, 41–48 (1987). CASPubMed Google Scholar
Leone, G., DeGregori, J., Jakoi, L. & Nevins, J. R. Collaboration of E2F and cyclin E/cdk2 in the induction of S phase. Proc. Natl Acad. Sci. USA (submitted).
Hatekeyama, M., Brill, J. A., Fink, G. R. & Weinberg, R. A. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev.8, 1759–1771 (1994). Article Google Scholar
Resnitzky, D. & Reed, S. I. Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol. Cell. Biol.15, 3463–3469 (1995). ArticleCAS Google Scholar
Galaktionov, K., Chen, X. & Beach, D. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature382, 511–517 (1996). ArticleADSCAS Google Scholar
Duronio, R. J., O'Farrell, P. H., Xie, J.-E., Brook, A. & Dyson, N. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev.9, 1445–1455 (1995). ArticleCAS Google Scholar
Duronio, R. J., Brook, A., Dyson, N. & O'Farrell, P. H. E2F-induced S phase requires cyclin E. Genes Dev.10, 2505–2513 (1996). ArticleCAS Google Scholar
Steiner, P. et al. Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J.14, 4814–4826 (1995). ArticleCAS Google Scholar
Coats, S., Flanagan, W. M., Nourse, J. & Roberts, J. M. Requirement of p27Kipl for restriction point control of the fibroblast cell cycle. Science272, 877–880 (1996). ArticleADSCAS Google Scholar
Nourse, J. et al. Interleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin. Nature372, 570–573 (1994). ArticleADSCAS Google Scholar
Galaktionov, K., Jessus, C. & Beach, D. Rafl interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Dev.9, 1046–1058 (1995). ArticleCAS Google Scholar
Nevins, J. R., DeGregori, J., Jakoi, L. & Leone, G. Functional analysis of E2F. Methods Enzymol. (in the press).
DeGregori, J., Kowalik, T. & Nevins, J. R. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis and G1/S regulatory cells. Mol. Cell. Biol.15, 4215–4224 (1995). ArticleCAS Google Scholar
Schwarz, J. K. et al. Expression of the E2F1 transcription factor overcomes type β transforming growth factor-mediated growth suppression. Proc. Natl Acad. Sci. USA92, 483–487 (1995). ArticleADSCAS Google Scholar
Farnsworth, C. L. & Reig, L. A. Dominant inhibitory mutations in the Mg2+-binding site of RasH prevent its activation by GTP. Mol. Cell. Biol.11, 4822–4829 (1991). ArticleCAS Google Scholar
Khosravi-Far, R., Solski, P. A., Clark, G. J., Kinch, M. S. & Der, C. J. Activation of Racl, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell. Biol.15, 6443–6453 (1995). ArticleCAS Google Scholar
Ikeda, M.-A., Jakoi, L. & Nevins, J. R. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc. Natl Acad. Sci. USA93, 3215–3220 (1996). ArticleADSCAS Google Scholar
Jacks, T. et al. Effects of an Rb mutation in the mousse. Nature359, 295–300 (1992). ArticleADSCAS Google Scholar
Smith, E. J., Leone, G., DeGregori, J., Jakoi, L. & Nevins, J. R. The accumulation of an E2F-p130 transcriptional represser distinguishes a GO from a Gl cell state. Mol. Cell. Biol.16, 6965–6976 (1996). ArticleCAS Google Scholar
DeGregori, J., Leone, G., Ohtani, K., Miron, A. & Nevins, J. R. E2F1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev.9, 2873–2887 (1995). ArticleCAS Google Scholar