A new SIV co-receptor, STRL33 (original) (raw)

Nature volume 388, page 238 (1997)Cite this article

Abstract

The identification last year of chemokine receptors as fusion co-factors for HIV-11,2,3,4,5,6 has contributed significantly towards understanding HIV transmission and AIDS pathogenesis (see ref. 7 for a review). Because the experimental infection of rhesus macaques with simian immunodeficiency virus (SIV) and the resulting development of an AIDS-like illness is the best animal model for HIV disease in humans8, identifying SIV co-receptors analogous to those used by HIV has obvious importance. We now report that STRL33, a chemokine receptor-like orphan receptor expressed in activated human lymphocytes and acting as a fusion co-factor with envelope glycoproteins (Envs) from HIV-1 strains of diverse tropisms9, is a co-receptor for SIV.

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Figure 1: SIV co-receptor activity of STRL33, also referred to as Bonzo18.

References

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Authors and Affiliations

  1. *Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, 20892, Maryland, USA
    Ghalib Alkhatib & Edward A. Berger
  2. †Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, 20892, Maryland, USA
    Fang Liao & Joshua M. Farber
  3. Laboratory of Retrovirus Research, CBER, Food and Drug Administration, Bethesda, 20892, Maryland, USA
    Keith W. C. Peden

Authors

  1. Ghalib Alkhatib
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  2. Fang Liao
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  3. Edward A. Berger
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  4. Joshua M. Farber
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  5. Keith W. C. Peden
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Alkhatib, G., Liao, F., Berger, E. et al. A new SIV co-receptor, STRL33.Nature 388, 238 (1997). https://doi.org/10.1038/40789

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