A new SIV co-receptor, STRL33 (original) (raw)

Nature volume 388, page 238 (1997)Cite this article

Abstract

The identification last year of chemokine receptors as fusion co-factors for HIV-11,2,3,4,5,6 has contributed significantly towards understanding HIV transmission and AIDS pathogenesis (see ref. 7 for a review). Because the experimental infection of rhesus macaques with simian immunodeficiency virus (SIV) and the resulting development of an AIDS-like illness is the best animal model for HIV disease in humans8, identifying SIV co-receptors analogous to those used by HIV has obvious importance. We now report that STRL33, a chemokine receptor-like orphan receptor expressed in activated human lymphocytes and acting as a fusion co-factor with envelope glycoproteins (Envs) from HIV-1 strains of diverse tropisms9, is a co-receptor for SIV.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: SIV co-receptor activity of STRL33, also referred to as Bonzo18.

References

  1. Feng, Y., Broder, C. C., Kennedy, P. E. & Berger, E. A. Science 272, 872-877 (1996).
  2. Deng, H. et al.Nature 381, 661-666 (1996).
  3. Dragic, T. et al.Nature 381, 667-673 (1996).
  4. Alkhatib, G. et al.272, 1955-1958 (1996).
  5. Choe, H. et al.85, 1135-1148 (1996).
  6. Doranz, B. J. et al.85, 1149-1158 (1996).
  7. Fauci, A. S. Nature 384, 529-534 (1996).
  8. Desrosiers, R. C. AIDS 9, Suppl. A S137-S141 (1995).
  9. Liao, F. et al.185, 2015-2023 (1997).
  10. Chen, Z., Zhou, P., Ho, D. D., Landau, N. R. & Marx, P. A. J. Virol. 71, 2705-2714 (1997).
  11. Marcon, L. et al.71, 2522-2527 (1997).
  12. Edinger, A. L. et al.94, 4005-4010 (1997).
  13. Nussbaum, O., Broder, C. C. & Berger, E. A. J. Virol. 68, 5411-5422 (1994).
  14. Biti, R. et al.3, 252-253 (1997).
  15. O’Brien, T. R. et al.349, 1219 (1997).
  16. Theodorou, I., Meyer, L., Magierowska, M., Katlama, C. & Rouzioux, C. Lancet 349, 1219-1220 (1997).
  17. Chen, Z. et al.70, 3617-3627 (1996).
  18. Nature 388, 296-300 (1997).

Download references

Author information

Authors and Affiliations

  1. *Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, 20892, Maryland, USA
    Ghalib Alkhatib & Edward A. Berger
  2. †Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, 20892, Maryland, USA
    Fang Liao & Joshua M. Farber
  3. Laboratory of Retrovirus Research, CBER, Food and Drug Administration, Bethesda, 20892, Maryland, USA
    Keith W. C. Peden

Authors

  1. Ghalib Alkhatib
  2. Fang Liao
  3. Edward A. Berger
  4. Joshua M. Farber
  5. Keith W. C. Peden

Rights and permissions

About this article

Cite this article

Alkhatib, G., Liao, F., Berger, E. et al. A new SIV co-receptor, STRL33.Nature 388, 238 (1997). https://doi.org/10.1038/40789

Download citation

This article is cited by