A new SIV co-receptor, STRL33 (original) (raw)
- Scientific Correspondence
- Published: 17 July 1997
Nature volume 388, page 238 (1997)Cite this article
- 514 Accesses
- 119 Citations
- 3 Altmetric
- Metrics details
Abstract
The identification last year of chemokine receptors as fusion co-factors for HIV-11,2,3,4,5,6 has contributed significantly towards understanding HIV transmission and AIDS pathogenesis (see ref. 7 for a review). Because the experimental infection of rhesus macaques with simian immunodeficiency virus (SIV) and the resulting development of an AIDS-like illness is the best animal model for HIV disease in humans8, identifying SIV co-receptors analogous to those used by HIV has obvious importance. We now report that STRL33, a chemokine receptor-like orphan receptor expressed in activated human lymphocytes and acting as a fusion co-factor with envelope glycoproteins (Envs) from HIV-1 strains of diverse tropisms9, is a co-receptor for SIV.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Figure 1: SIV co-receptor activity of STRL33, also referred to as Bonzo18.
References
- Feng, Y., Broder, C. C., Kennedy, P. E. & Berger, E. A. Science 272, 872-877 (1996).
- Deng, H. et al.Nature 381, 661-666 (1996).
- Dragic, T. et al.Nature 381, 667-673 (1996).
- Alkhatib, G. et al.272, 1955-1958 (1996).
- Choe, H. et al.85, 1135-1148 (1996).
- Doranz, B. J. et al.85, 1149-1158 (1996).
- Fauci, A. S. Nature 384, 529-534 (1996).
- Desrosiers, R. C. AIDS 9, Suppl. A S137-S141 (1995).
- Liao, F. et al.185, 2015-2023 (1997).
- Chen, Z., Zhou, P., Ho, D. D., Landau, N. R. & Marx, P. A. J. Virol. 71, 2705-2714 (1997).
- Marcon, L. et al.71, 2522-2527 (1997).
- Edinger, A. L. et al.94, 4005-4010 (1997).
- Nussbaum, O., Broder, C. C. & Berger, E. A. J. Virol. 68, 5411-5422 (1994).
- Biti, R. et al.3, 252-253 (1997).
- O’Brien, T. R. et al.349, 1219 (1997).
- Theodorou, I., Meyer, L., Magierowska, M., Katlama, C. & Rouzioux, C. Lancet 349, 1219-1220 (1997).
- Chen, Z. et al.70, 3617-3627 (1996).
- Nature 388, 296-300 (1997).
Author information
Authors and Affiliations
- *Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, 20892, Maryland, USA
Ghalib Alkhatib & Edward A. Berger - †Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, 20892, Maryland, USA
Fang Liao & Joshua M. Farber - Laboratory of Retrovirus Research, CBER, Food and Drug Administration, Bethesda, 20892, Maryland, USA
Keith W. C. Peden
Authors
- Ghalib Alkhatib
You can also search for this author inPubMed Google Scholar - Fang Liao
You can also search for this author inPubMed Google Scholar - Edward A. Berger
You can also search for this author inPubMed Google Scholar - Joshua M. Farber
You can also search for this author inPubMed Google Scholar - Keith W. C. Peden
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Alkhatib, G., Liao, F., Berger, E. et al. A new SIV co-receptor, STRL33.Nature 388, 238 (1997). https://doi.org/10.1038/40789
- Issue Date: 17 July 1997
- DOI: https://doi.org/10.1038/40789