Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors (original) (raw)
References
Thien, C. B. & Langdon, W. Y. Cbl: many adaptations to regulate protein tyrosine kinases. Nature Rev. Mol. Cell Biol.2, 294–307 (2001). ArticleCAS Google Scholar
Joazeiro, C. A. et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science286, 309–312 (1999). ArticleCAS Google Scholar
Levkowitz, G. et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol. Cell4, 1029–1040 (1999). ArticleCAS Google Scholar
Waterman, H. & Yarden, Y. Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases. FEBS Lett.490, 142–152 (2001). ArticleCAS Google Scholar
Di Fiore, P. P. & De Camilli, P. Endocytosis and signaling. An inseparable partnership. Cell106, 1–4 (2001). ArticleCAS Google Scholar
Take, H. et al. Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl. Biochem. Biophys. Res. Commun.268, 321–328 (2000). ArticleCAS Google Scholar
Schmidt, A. et al. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. Nature401, 133–141 (1999). ArticleADSCAS Google Scholar
Ringstad, N. et al. Endophilin/SH3p4 is required for the transition from early to late stages in clathrin-mediated synaptic vesicle endocytosis. Neuron24, 143–154 (1999). ArticleCAS Google Scholar
Simpson, F. et al. SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. Nature Cell Biol.1, 119–124 (1999). ArticleCAS Google Scholar
Gad, H. et al. Fission and uncoating of synaptic clathrin-coated vesicles are perturbed by disruption of interactions with the SH3 domain of endophilin. Neuron27, 301–312 (2000). ArticleCAS Google Scholar
Yoon, C. H., Chang, C., Hopper, N. A., Lesa, G. M. & Sternberg, P. W. Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation. Mol. Biol. Cell11, 4019–4031 (2000). ArticleCAS Google Scholar
Gout, I. et al. Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein. EMBO J.19, 4015–4025 (2000). ArticleCAS Google Scholar
Bogler, O. et al. SETA: a novel SH3 domain-containing adapter molecule associated with malignancy in astrocytes. Neuro-oncology.2, 6–15 (2000). ArticleCAS Google Scholar
Kirsch, K. H. et al. The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. J. Biol. Chem.276, 4957–4963 (2001). ArticleCAS Google Scholar
Watanabe, S. et al. Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes. Biochem. Biophys. Res. Commun.278, 167–174 (2000). ArticleCAS Google Scholar
Borinstein, S. C. et al. SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins. Cell Signal12, 769–779 (2000). ArticleCAS Google Scholar
Ringstad, N., Nemoto, Y. & De Camilli, P. The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. Proc. Natl Acad. Sci. USA94, 8569–8574 (1997). ArticleADSCAS Google Scholar
Micheva, K. D., Ramjaun, A. R., Kay, B. K. & McPherson, P. S. SH3 domain-dependent interactions of endophilin with amphiphysin. FEBS Lett.414, 308–312 (1997). ArticleCAS Google Scholar
Farsad, K. et al. Generation of high curvature membranes mediated by direct endophilin bilayer interactions. J. Cell Biol.155, 193–200 (2001). ArticleCAS Google Scholar
de Melker, A. A., van Der Horst, G., Calafat, J., Jansen, H. & Borst, J. c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route. J. Cell Sci.114, 2167–2178 (2001). CASPubMed Google Scholar
Levkowitz, G. et al. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev.12, 3663–3674 (1998). ArticleCAS Google Scholar
Petrelli, A. et al. The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met. Nature416, 187–190 (2001). ArticleADS Google Scholar
Galisteo, M. L., Dikic, I., Batzer, A. G., Langdon, W. Y. & Schlessinger, J. Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. J. Biol. Chem.270, 20242–20245 (1995). ArticleCAS Google Scholar
Scaife, R. M. & Langdon, W. Y. c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology. J. Cell Sci.113(2), 215–226 (2000). CAS Google Scholar
Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S. A. & Schlessinger, J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature383, 547–550 (1996). ArticleADSCAS Google Scholar
Ivankovic-Dikic, I., Gronroos, E., Blaukat, A., Barth, B. U. & Dikic, I. Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. Nature Cell Biol.2, 574–581 (2000). ArticleCAS Google Scholar
Sorkin, A., Mazzotti, M., Sorkina, T., Scotto, L. & Beguinot, L. Epidermal growth factor receptor interaction with clathrin adaptors is mediated by the Tyr974-containing internalization motif. J. Biol. Chem.271, 13377–13384 (1996). ArticleCAS Google Scholar