Two paths to silence merge (original) (raw)

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• Published: 15 February 2006

Developmental biology

Nature volume 439, pages 794–795 (2006)Cite this article

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To maintain their identity across generations, specialized cells must heritably repress swathes of genes — keeping active only genes necessary for the cell's purpose. Now it seems two repressive pathways join forces.

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References

1. Viré, E. et al. Nature 439, 871–874 (2006).
   Article ADS Google Scholar
2. Li, E. Nature Rev. Genet. 3, 662–673 (2002).
   Article CAS Google Scholar
3. Kuzmichev, A., Jenuwein, T., Tempst, P. & Reinberg, D. Mol. Cell 14, 183–193 (2004).
   Article CAS Google Scholar
4. Lund, A. H. & van Lohuizen, M. Curr. Opin. Cell Biol. 16, 239–246 (2004).
   Article CAS Google Scholar
5. Ringrose, L. & Paro, R. Annu. Rev. Genet. 25, 413–434 (2004).
   Article Google Scholar
6. Yu-ichi, T. et al. Nature advance online publication doi:10.1038/nature04433 (2005).
7. Lehnertz, B. et al. Curr. Biol. 13, 1192–1200 (2003).
   Article CAS Google Scholar
8. Hernández-Muñoz, I., Taghavi, P., Kuijl, C., Neefjes, J. & van Lohuizen, M. Mol. Cell. Biol. 25, 11047–11058 (2005).
   Article Google Scholar
9. Heard, E. Curr. Opin. Cell Biol. 16, 1–9 (2004).
   Article Google Scholar
10. Umlauf, D. et al. Nature Genet. 12, 1296–1300 (2004).
    Article Google Scholar
11. Lewis, A. et al. Nature Genet. 12, 1291–1295 (2004).
    Article Google Scholar
12. Yu-Wei, L. et al. Cancer Res. 64, 8184–8192 (2004).
    Article Google Scholar
13. Feldman, N. et al. Nature Cell Biol. advance online publication doi:10.1038/ncb1353 (2006).
14. Grace Goll, M. & Bestor, T. H. Annu. Rev. Biochem. 74, 481–514 (2005).
    Article Google Scholar
15. Marhold, J., Kramer, K., Kremmer, E. & Lyko, F. Development 131, 6033–6039 (2004).
    Article CAS Google Scholar

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Authors and Affiliations

1. the Division of Molecular Genetics, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands
   Panthea Taghavi & Maarten van Lohuizen

Authors

1. Panthea Taghavi
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2. Maarten van Lohuizen
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Taghavi, P., van Lohuizen, M. Two paths to silence merge.Nature 439, 794–795 (2006). https://doi.org/10.1038/439794a

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• Published: 15 February 2006
• Issue Date: 16 February 2006
• DOI: https://doi.org/10.1038/439794a

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