Metabonomics (original) (raw)

• News and Views Q&A
• Published: 22 October 2008

Systems biology

Nature volume 455, pages 1054–1056 (2008)Cite this article

• 28k Accesses
• 1787 Citations
• 99 Altmetric
• Metrics details

Organisms often respond in complex and unpredictable ways to stimuli that cause disease or injury. By measuring and mathematically modelling changes in the levels of products of metabolism found in biological fluids and tissues, metabonomics offers fresh insight into the effects of diet, drugs and disease.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

• The longitudinal biochemical profiling of TBI in a drop weight model of TBI

  • Ali Yilmaz
  • , Sigal Liraz-Zaltsman
  • … Stewart F. Graham
    Scientific Reports Open Access 14 December 2023

• Joint analysis of the metabolomics and transcriptomics uncovers the dysregulated network and develops the diagnostic model of high-risk neuroblastoma

  • Bang Du
  • , Fei Zhang
  • … Wancun Zhang
    Scientific Reports Open Access 09 October 2023

• Serum metabolomic profile of hair dye use

  • Jung-eun Lim
  • , Jiaqi Huang
  • … Demetrius Albanes
    Scientific Reports Open Access 07 March 2023

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

• Purchase on SpringerLink
• Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

• Log in
• Learn about institutional subscriptions
• Read our FAQs
• Contact customer support

References

1. Nicholson, J. K. & Wilson, I. D. Understanding 'global' systems biology: Metabonomics and the continuum of metabolism. Nature Rev. Drug Discov. 2, 668–676 (2003).
   Article CAS Google Scholar
2. Dethlefsen, L., McFall-Ngai, M. & Relman, D. A. An ecological and evolutionary perspective on human–microbe mutualism and disease. Nature 449, 811–818 (2007).
   Article ADS CAS Google Scholar
3. Lenz, E. M. & Wilson, I. D. Analytical strategies in metabonomics. J. Proteome Res. 6, 443–458 (2007).
   Article CAS Google Scholar
4. Wishart, D. S. et al. HMDB: The Human Metabolome Database. Nucleic Acids Res. 35, D521–D526 (2007).
   Article CAS Google Scholar
5. Holmes, E., Wilson, I. D. & Nicholson, J. K. Metabolic phenotyping in health and disease. Cell 134, 714–717 (2008).
   Article CAS Google Scholar
6. Holmes, E. et al. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 453, 396–400 (2008).
   Article ADS CAS Google Scholar

Download references

Author information

Authors and Affiliations

1. Jeremy K. Nicholson and John C. Lindon are in the Department of Biomolecular Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK,
   Jeremy K. Nicholson & John C. Lindon

Authors

1. Jeremy K. Nicholson
2. John C. Lindon

Rights and permissions

About this article

Cite this article

Nicholson, J., Lindon, J. Metabonomics.Nature 455, 1054–1056 (2008). https://doi.org/10.1038/4551054a

Download citation

• Published: 22 October 2008
• Issue date: 23 October 2008
• DOI: https://doi.org/10.1038/4551054a

This article is cited by