Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides (original) (raw)

• Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432 (1994).
  Article CAS Google Scholar
• Montague, C.T. et al. Congenital leptin deficiency is associated with severe early–onset obesity in humans. Nature 387, 903– 908 (1997).
  Article CAS Google Scholar
• Lee, G.–H. et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632–635 (1996).
  Article CAS Google Scholar
• Clement, K. et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398 –401 (1998).
  Article CAS Google Scholar
• Krude, H. et al. Severe early–onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genet. 19, 155–157 ( 1998).
  Article CAS Google Scholar
• Huszar, D. et al. Targeted disruption of the melanocortin–4 receptor results in obesity in mice. Cell 88, 131– 141 (1997).
  Article CAS Google Scholar
• Manne, J., Argeson, A.C. & Siracusa, L.D. Mechanisms for the pleiotropic effects of the agouti gene. Proc. Natl Acad. Sci. USA 92, 4721 –4724 (1995).
  Article CAS Google Scholar
• Ollmann, M.M. et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti–related protein. Science 278 , 135–138 (1997).
  Article CAS Google Scholar
• Lu, D. et al. Agouti protein is an antagonist of the melanocyte–stimulating–hormone receptor. Nature 371, 799– 802 (1994).
  Article CAS Google Scholar
• Gantz, I. et al. Molecular cloning of a novel melanocortin receptor. J. Biol. Chem. 268, 8246–8250 (1993).
  CAS PubMed Google Scholar
• Gantz, I. et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J. Biol. Chem. 268, 15174–15179 (1993).
  CAS PubMed Google Scholar
• Hruby, V.J. et al. Cyclic lactam α–melanotropin analogues of Ac–Nle4–cyclo[Asp5, D–Phe7, Lys10] α–melanocyte–stimulating hormone–(4–10)–NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J. Med. Chem. 38, 3454–3461 ( 1995).
  Article CAS Google Scholar
• Halaas, J.L. et al. Physiological response to long–term peripheral and central leptin infusion in lean and obese mice. Proc. Natl Acad. Sci. USA 94, 8878–8883 ( 1997).
  Article CAS Google Scholar
• Boston, B.A., Blaydon, K.M., Varnerin, J. & Cone, R.D. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 278, 1641– 1644 (1997).
  Article CAS Google Scholar
• Starr, R. et al. A family of cytokine–inducible inhibitors of signalling. Nature 387, 917–921 (1997).
  Article CAS Google Scholar
• Bjorbaek, C., Elmquist, J.K., Frantz, J.D., Shoelson, S.E. & Flier, J.S. Identification of SOCS–3 as a potential mediator of central leptin resistance. Mol. Cell 1, 619–625 (1998).
  Article CAS Google Scholar
• Friedman, J.M. & Halaas, J.L. Leptin and the regulation of body weight in mammals. Nature 395, 763–770 (1998).
  Article CAS Google Scholar
• Gloaguen, I. et al. Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc. Natl Acad. Sci. USA 94, 6456–6461 ( 1997).
  Article CAS Google Scholar
• Schwartz, M.W., Seeley, R.J., Campfield, L.A., Burn, P. & Baskin, D.G. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98, 1101–1106 (1996).
  Article CAS Google Scholar
• Hollopeter, G., Erickson, J.C., Seeley, R.J., Marsh, D.J. & Palmiter, R.D. Response of neuropeptide Y–deficient mice to feeding effectors. Regul. Pept. (in press).
• Costa, A. et al. Stimulation of corticotrophin–releasing hormone release by the obese (ob) gene product, leptin, from hypothalamic explants. Neuroreport 8, 1131–1134 (1997).
  Article CAS Google Scholar
• Spina, M. et al. Appetite–suppressing effects of urocortin, a CRF–related neuropeptide. Science 273, 1561– 1564 (1996).
  Article CAS Google Scholar
• Muglia, L., Jacobson, L., Dikkes, P. & Majzoub, J.A. Corticotropin–releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 373, 427–432 (1995).
  Article CAS Google Scholar
• Smith, G.W. et al. Corticotopin releasing factor receptor 1–deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20, 1093– 1102 (1998).
  Article CAS Google Scholar
• Sahu, A., Kalra, P.S. & Kalra, S.P. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 9, 83–86 ( 1988).
  Article CAS Google Scholar
• Hahn, T., Breininger, J., Baskin, D. & Schwartz, M. Coexpression of Agrp and NPY in fasting–activated hypothalamic neurons. Nature Neurosci. 1, 271– 272 (1998).
  Article CAS Google Scholar
• De Lecea, L. et al. The hypocretins: hypothalamus–specific peptides with neuroexcitability activity. Proc. Natl Acad. Sci. USA 95, 322–327 (1998).
  Article CAS Google Scholar
• Sakurai, T. et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein–coupled receptors that regulate feeding behavior. Cell 92, 573–585 ( 1998).
  Article CAS Google Scholar
• Erickson, J.C., Clegg, K.E. & Palmiter, R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381, 415–418 (1996).
  Article CAS Google Scholar
• Di Marco, A. et al. Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists. Proc. Natl Acad. Sci. USA 93, 9247–9252 (1996).
  Article CAS Google Scholar