Runt domains take the lead in hematopoiesis and osteogenesis (original) (raw)

Nature Medicine volume 5, pages 1356–1357 (1999)Cite this article

Abstract

It has been nearly a decade since AML1 was first identified as the DNA-binding protein PEBP2αB/CBFA2 in mice. Molecular, genetic and biochemical studies have converged to reveal new information about how this unique family of transcription factors functions, and the linkage between developmental processes and human disease.

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Figure 1: Three-dimensional structure of the Runt domain and location of mutations causing deficiencies in DNA binding associated with AML, FPD and CCD.

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Authors and Affiliations

  1. Laboratory of Molecular Biophysics The Rockefeller University, 1230 York Avenue, New York, 10021, New York, USA
    Milton H. Werner
  2. Departments of Viral Oncology, Genetics and Molecular Biology, Institute for Virus Research, Kyoto University, Sakyo-ku, 606, Kyoto, Japan
    Katsuya Shigesada & Yoshiaki Ito

Authors

  1. Milton H. Werner
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  2. Katsuya Shigesada
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  3. Yoshiaki Ito
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Werner, M., Shigesada, K. & Ito, Y. Runt domains take the lead in hematopoiesis and osteogenesis.Nat Med 5, 1356–1357 (1999). https://doi.org/10.1038/70920

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