HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine (original) (raw)

References

  1. Craig, E.A. & Gross, C.A. Is hsp70 the cellular thermometer? Trends Biochem. Sci. 16, 135–40 (1991).
    Article CAS Google Scholar
  2. Lindquist, S. & Craig, E.A. The heat-shock proteins. Annu. Rev. Genet. 22, 631–77 (1988).
    Article CAS Google Scholar
  3. Calderwood, S.K. in Proceedings of the 86th Annual Meeting of the American Association for Cancer Research 682, (American Association for Cancer Research, Philadelphia, Pennsylvania, 1995).
    Google Scholar
  4. Minota, S., Cameron, B., Welch, W. J. & Winfield, J. B. Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus. J. Exp. Med. 168, 1475–1480 (1988).
    Article CAS Google Scholar
  5. Schletter, J., Heine, H., Ulmer, A.J. & Rietschel, E. T. Molecular mechanisms of endotoxin activity. Arch. Microbiol. 164, 383–389 (1995).
    Article CAS Google Scholar
  6. Housby, J.N. et al. Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce hsp70 in human monocytes. Cytokine 11, 347–358 (1999).
    Article CAS Google Scholar
  7. Golenbock, D.T., Hampton, R.Y., Qureshi, N., Takayama, K. & Raetz, C.R. Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes. J. Biol. Chem. 266, 19490–19498 (1991).
    CAS Google Scholar
  8. Duff, G. W. & Atkins, E. The inhibitory effect of polymyxin B on endotoxin-induced endogenous pyrogen production. J. Immunol. Methods 52, 333–340 (1982).
    Article CAS Google Scholar
  9. Ghosh, S., May, M.J. & Kopp, E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225–260 (1998).
    Article CAS Google Scholar
  10. Baeuerle, P.A. & Baltimore, D. I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242, 540–546 (1988).
    Article CAS Google Scholar
  11. Beg, A.A. & Baldwin, A.S. Jr. The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors. Genes Dev. 7, 2064–2070 (1993).
    Article CAS Google Scholar
  12. Stevenson, M.A., Zhao, M.-J., Asea, A., Coleman, N.C. & Calderwood, S.K. Salicylic acid and asprin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of CREB and NF-κB responsive genes. J. Immunol. 163, 5608–5616 (1999).
    CAS PubMed Google Scholar
  13. Rollins, B.J., Walz, A. & Baggiolini, M. Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes. Blood 78, 1112–1116 (1991).
    CAS PubMed Google Scholar
  14. McLeish, K.R., Dean, W.L., Wellhausen, S.R. & Stelzer, G.T. Role of intracellular calcium in priming of human peripheral blood monocytes by bacterial lipopolysaccharide. Inflammation 13, 681–692 (1989).
    Article CAS Google Scholar
  15. Ulevitch, R.J. & Tobias, P.S. Recognition of endotoxin by cells leading to transmembrane signaling. Curr. Opin. Immunol. 6, 125–130 (1994).
    Article CAS Google Scholar
  16. Tapping, R.I., Orr, S.L., Lawson, E.M., Soldau, K. & Tobias, P.S. Membrane-anchored forms of lipopolysaccharide (LPS)-binding protein do not mediate cellular responses to LPS independently of CD14. J. Immunol. 162, 5483–5489 (1999).
    CAS PubMed Google Scholar
  17. Solomon, K.R. et al. Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide. J. Clin. Invest. 102, 2019–2027 (1998).
    Article CAS Google Scholar
  18. Arnold-Schild, D. et al. Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells. J. Immunol. 162, 3757–3760 (1999).
    CAS PubMed Google Scholar
  19. Kaufmann, S.H.E. & Schoel, B. in The Biology of Heat Shock Proteins and Molecular Chaperones (eds. Morimoto, R. I., Tissieres, A. & Georgopoulos, C.) 495–531 (Cold Spring Harbor Laboratory, Plainview, New York, 1994).
    Google Scholar
  20. Haregewoin, A., Soman, G., Hom, R.C. & Finberg, R.W. Human gamma delta+ T cells respond to mycobacterial heat-shock protein. Nature 340, 309–312 (1989).
    Article CAS Google Scholar
  21. Haregewoin, A., Singh, B., Gupta, R.S. & Finberg, R.W. A mycobacterial heat-shock protein-responsive gamma delta T cell clone also responds to the homologous human heat-shock protein: a possible link between infection and autoimmunity. J. Infect. Dis. 163, 156–160 (1991).
    Article CAS Google Scholar
  22. van Eden, W. et al. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 331, 171–173 (1988).
    Article CAS Google Scholar
  23. Holoshitz, J., Koning, F., Coligan, J.E., De Bruyn, J. & Strober, S. Isolation of CD4- CD8- mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 339, 226–229 (1989).
    Article CAS Google Scholar
  24. Holoshitz, J., Matitiau, A. & Cohen, I.R. Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. J. Clin. Invest. 73, 211–215 (1984).
    Article CAS Google Scholar
  25. van Eden, W. et al. Heat-shock protein T-cell epitopes trigger a spreading regulatory control in a diversified arthritogenic T-cell response. Immunol. Rev. 164, 169–174 (1998).
    Article CAS Google Scholar
  26. Kol, A., Lichtman, A.H., Finberg, R.W., Libby, P. & Kurt-Jones, E.A. Cutting edge: Heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells. J. Immunol. 164, 13–17 (2000).
    Article CAS Google Scholar
  27. Yang, R. B. et al. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395, 284–248 (1998).
    Article CAS Google Scholar
  28. Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085–2088 (1998).
    Article CAS Google Scholar
  29. Hoshino, K. et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice Are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the LPS gene oroduct. J. Immunol. 162, 3749–3752 (1999).
    CAS Google Scholar
  30. Zhang, F.X. et al. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 274, 7611–7614 (1999).
    Article CAS Google Scholar
  31. Todryk, S. et al. Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake. J. Immunol. 163, 1398–1408 (1999).
    CAS PubMed Google Scholar
  32. Suto, R. & Srivastava, P.K. A mechanism for the specific immunogenicity of heat shock protein- chaperoned peptides. Science 269, 1585–1588 (1995).
    Article CAS Google Scholar
  33. Srivastava, P.K., Udono, H., Blachere, N.E. & Li, Z. Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics 39, 93–98 (1994).
    Article CAS Google Scholar
  34. Srivastava, P.K., Menoret, A., Basu, S., Binder, R.J. & McQuade, K.L. Heat shock proteins come of age: primitive functions acquire new roles in an adaptive world. Immunity 8, 657–665 (1998).
    Article CAS Google Scholar
  35. Srivastava, P.K. & Udono, H. Heat shock protein-peptide complexes in cancer immunotherapy. Curr. Opin. Immunol. 6, 728–732 (1994).
    Article CAS Google Scholar
  36. Tamura, Y., Peng, P., Liu, K., Daou, M. & Srivastava, P.K. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Science 278, 117–120 (1997).
    Article CAS Google Scholar
  37. Soncin, F. & Calderwood, S.K. Reciprocal effects of pro-inflammatory stimuli and anti-inflammatory drugs on the activity of heat shock factor-1 in human monocytes. Biochem. Biophys. Res. Commun. 229, 479–484 (1996).
    Article CAS Google Scholar
  38. Sistonen, L., Sarge, K.D. & Morimoto, R.I. Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Mol. Cell Biol. 14, 2087–2099 (1994).
    Article CAS Google Scholar
  39. Baler, R., Zou, J. & Voellmy, R. Evidence for a role of Hsp70 in the regulation of the heat shock response in mammalian cells. Cell Stress Chaperones 1, 33–39 (1996).
    Article CAS Google Scholar
  40. Janeway, C.A. & Travers, P. Immunobiology: The Immune System in Health and Disease (eds. Janeway, C.A. & Travers, P.) (Garland Publishing, New York, 1997).
  41. Asea, A. Role of Histamine in the Regulation of Natural Killer Cells. Doctoral dissertation, Univ. Göteborg (Göteborg, Sweden, 1995).
  42. Asea, A. et al. Histaminergic regulation of interferon-gamma (IFN-gamma) production by human natural killer (NK) cells. Clin. Exp. Immunol. 105, 376–382 (1996).
    Article CAS Google Scholar
  43. Hansson, M., Asea, A., Ersson, U., Hermodsson, S. & Hellstrand, K. Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites. J. Immunol. 156, 42–47 (1996).
    CAS PubMed Google Scholar
  44. Koo, G.C. et al. Association of serine protease with the rise of intracellular calcium in cytotoxic T lymphocytes. Cell. Immunol. 174, 107–115 (1996).
    Article CAS Google Scholar

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