Mice lacking the norepinephrine transporter are supersensitive to psychostimulants (original) (raw)

References

1. Feldman, R. S., Meyer, J. S. & Quenzer, L. F. Principles of Neuropsychopharmacology 324–344 (Sinauer, Sunderland, Massachusetts, 1992).
   Google Scholar
2. Axelrod, J. & Kopin, I. J. The uptake, storage, release and metabolism of noradrenaline in sympathetic nerves. Prog. Brain Res. 31, 21–32 (1969).
   Article CAS Google Scholar
3. Lindvall, O. & Bjorklund, A. in Chemical Neuroanatomy (ed. Emson, P. C.) 229–255 (Raven, New York, 1983).
   Google Scholar
4. Amara, S. G. & Kuhar, M. J. Neurotransmitter transporters: recent progress. Annu. Rev. Neurosci. 16, 73–93 (1993).
   Article CAS Google Scholar
5. Giros, B. & Caron, M. G. Molecular characterization of the dopamine transporter. Trends Pharmacol. Sci. 14, 43–49 (1993).
   Article CAS Google Scholar
6. Pacholczyk, T., Blakely, R. D. & Amara, S. G. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature 350, 350–354 (1991).
   Article CAS Google Scholar
7. Fritz, J. D., Jayanthi, L. D., Thoreson, M. A. & Blakely, R. D. Cloning and chromosomal mapping of the murine norepinephrine transporter. J. Neurochem. 70, 2241–2251 (1998).
   Article CAS Google Scholar
8. Markou, A., Kosten, T. R. & Koob, G. F. Neurobiological similarities in depression and drug dependence: a self- medication hypothesis. Neuropsychopharmacology 18, 135–174 (1998).
   Article CAS Google Scholar
9. Robinson, T. E. & Berridge, K. C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res. Rev. 18, 247–291 (1993).
   Article CAS Google Scholar
10. Jones, S. R. et al. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc. Natl. Acad. Sci. USA 95, 4029–4034 (1998).
    Article CAS Google Scholar
11. Gainetdinov, R. R., Jones, S. R., Fumagalli, F., Wightman, R. M. & Caron, M. G. Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis. Brain Res. Rev. 26, 148–153 (1998).
    Article CAS Google Scholar
12. Jones, S. R. et al. Loss of autoreceptor functions in mice lacking the dopamine transporter. Nat. Neurosci. 2, 649–655 (1999).
    Article CAS Google Scholar
13. Bengel, D. et al. Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine (‘Ecstasy’) in serotonin transporter- deficient mice. Mol. Pharmacol. 53, 649–655 (1998).
    Article CAS Google Scholar
14. Wang, Y. M. et al. Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. Neuron 19, 1285–1296 (1997).
    Article CAS Google Scholar
15. Palij P. & Stamford, J. A. Real-time monitoring of endogenous noradrenaline release in rat brain slices using fast cyclic voltammetry: 1. Characterization of evoked noradrenaline efflux and uptake from nerve terminals in the bed nucleus of stria terminalis, pars ventralis. Brain Res. 587, 137–146 (1992).
    Article CAS Google Scholar
16. Leonard, B. E. The role of noradrenaline in depression: a review. J. Psychopharmacol. 11, S39–S47 (1997).
    CAS Google Scholar
17. Hornig, A. & Van Praag, H. M. Depression: Neurobiological, Psychopathological and Therapeutic Advances (Wiley, New York, 1997).
    Google Scholar
18. Porsolt, R. D., Bertin, A. & Jalfre, M. Behavioral despair in mice: a primary screening test for antidepressants. Arch. Int. Pharmacodyn. Ther. 229, 327–336 (1977).
    CAS Google Scholar
19. Steru, L. et al. The automated tail suspension test: a computerized device which differentiates psychotropic drugs. Prog. Neuropsychopharmacol. Biol. Psychiatry 11, 659–671 (1987).
    Article CAS Google Scholar
20. Richelson, E. Synaptic effects of antidepressants. J. Clin. Psychopharmacol. 16, 1S–7S (1996).
    Article CAS Google Scholar
21. Giros, B. et al. Delineation of discrete domains for substrate, cocaine and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. J. Biol. Chem. 269, 15985–15988 (1994).
    CAS Google Scholar
22. Rossetti, Z. L., D'Aquila, P. S., Hmaidan, Y., Gessa, G. L. & Serra, G. Repeated treatment with imipramine potentiates cocaine-induced dopamine release and motor stimulation. Eur. J. Pharmacol. 201, 243–245 (1991).
    Article CAS Google Scholar
23. Willner, P. The mesolimbic dopamine system as a target for rapid antidepressant action. Int. Clin. Psychopharmacol. 12 (Suppl. 3), S7–S14 (1997).
    Article Google Scholar
24. Spyraki, C. & Fibiger, H. C. Behavioural evidence for supersensitivity of postsynaptic dopamine receptors in the mesolimbic system after chronic administration of desipramine. Eur. J. Pharmacol. 74, 195–206 (1981).
    Article CAS Google Scholar
25. Nestler, E. J. & Aghajanian, G. K. Molecular and cellular basis of addiction. Science 278, 58–63 (1997).
    Article CAS Google Scholar
26. Carr, G. D., Fibiger, H. C. & Phillips, A. G. in The Neuropharmacological Basis of Reward (eds. Liebman, J. M. & Cooper, S. J.) 265–319 (Clarendon, Oxford, 1989).
    Google Scholar
27. Giros, B., Jaber, M., Jones, S. R., Wightman, R. M. & Caron, M. G. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379, 606–612 (1996).
    Article CAS Google Scholar
28. Rocha, B. A. et al. Cocaine self-administration in dopamine-transporter knockout mice. Nat. Neurosci. 1, 132–137 (1998).
    Article CAS Google Scholar
29. Sora, I. et al. Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc. Natl. Acad. Sci. USA 95, 7699–7704 (1998).
    Article CAS Google Scholar
30. Reith, M. E. A. & Chen, N. in Neurotransmitter Transporters: Structure, Function and Regulation (ed. Reith, M. E. A.) 345–391 (Humana Press, Totowa, New Jersey, 1997).
    Book Google Scholar
31. Yavich, L., Lappalainen, R., Sirvio, J., Haapalinna, A. & MacDonald, E. Alpha2-adrenergic control of dopamine overflow and metabolism in mouse striatum. Eur. J. Pharmacol. 339, 113–119 (1997).
    Article CAS Google Scholar
32. Grenhoff, J. & Svensson, T. H. Clonidine modulates dopamine firing in rat ventral tegmental area. Eur. J. Pharmacol. 165, 11–18 (1989).
    Article CAS Google Scholar
33. Cragg, S. J., Rice, M. E. & Greenfield, S. A. Heterogeneity of electrically evoked dopamine release and reuptake in substantia nigra, ventral tegmental area and striatum. J. Neurophysiol. 77, 863–873 (1997).
    Article CAS Google Scholar
34. Willner P. Sensitization of dopamine D2- or D3-type receptors as a final common pathway in antidepressant drug action. Clin. Neuropharmacol. 18 (Suppl. 1), S49–S56 (1995).
    Article Google Scholar
35. Mann, J. J. & Kapur, S. A dopaminergic hypothesis of major depression. Clin. Neuropharm. 18, S57–S65 (1995).
    Article Google Scholar
36. Backstrom, I. T., Ross, S. B. & Marcusson, J. O. [3H]desipramine binding to rat brain tissue: binding to both noradrenaline uptake sites and sites not related to noradrenaline neurons. J. Neurochem. 52, 1099–1106 (1989).
    Article CAS Google Scholar
37. Krobert, K. A., Sutton, R. L. & Feeney, D. M. Spontaneous and amphetamine-evoked release of cerebellar noradrenaline after sensimotor cortex contusion: an in vivo microdialysis study in the awake rat. J. Neurochem. 62, 2233–2240 (1994).
    Article CAS Google Scholar
38. Gainetdinov, R. R. et al. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 283, 397–401 (1999).
    Article CAS Google Scholar
39. Gong, W., Neill, D. & Justice, J. B. Jr. Conditioned place preference and locomotor activation produced by injection of psychostimulants into ventral pallidum. Brain Res. 707, 64–74 (1996).
    Article CAS Google Scholar
40. Rinken, A., Finnman, U. B. & Fuxe, K. Pharmacological characterization of dopamine-stimulated [35S]-guanosine 5′-(λ-thiotriphosphate) ([35S]GTPλS) binding in rat striatal membranes. Biochem. Pharmacol. 57, 155–162 (1999).
    Article CAS Google Scholar

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