Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase (original) (raw)
Mizuno, Y., Hattori, N. & Matsumine, H. Neurochemical and neurogenetic correlates of Parkinson's disease. J. Neurochem.71, 893–902 (1998). ArticleCAS Google Scholar
Kitada, T. et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature392, 605–608 (1998). ArticleCAS Google Scholar
Mayer, R.J., Landon, M. & Lowe, J. Ubiquitin and the molecular pathology of human disease. in Ubiquitin and the Biology of the Cell. (eds Peters, J.-M., Harris, J.R. & Finley, D.) 429–462 (Plenum, New York, 1998). Chapter Google Scholar
Alves-Rodrigues, A., Gregori, L. & Figueiredo-Pereira, M.E. Ubiquitin, cellular inclusions and their role in neurodegeneration. Trends Neurosci.21, 516–520 (1998). ArticleCAS Google Scholar
Floyd, J.A. & Hamilton, B.A. Intranuclear inclusions and the ubiquitin-proteasome pathway: digestion of a red herring? Neuron24, 765–766 (1999). ArticleCAS Google Scholar
Pallares-Trujillo, J., Lopez-Soriano, F.J. & Argiles, J.M. The involvement of the ubiquitin system in Alzheimer's disease. Int. J. Mol. Med.2, 3–15 (1998). CASPubMed Google Scholar
DiFiglia, M. et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science277, 1990–1993 (1997). ArticleCAS Google Scholar
Cummings, C.J. et al. Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron24, 879–892 (1999). ArticleCAS Google Scholar
Leigh, P.N. et al. Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity. Brain114, 775–788 (1991). Article Google Scholar
Kuzuhara, S., Mori, H., Izumiyama, N., Yoshimura, M. & Ihara, Y. Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta. Neuropathol. (Berl)75, 345–353 (1988). ArticleCAS Google Scholar
Hershko, A. & Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem.67, 425–479 (1998). ArticleCAS Google Scholar
Hochstrasser, M. Ubiquitin-dependent protein degradation. Annu. Rev. Genet.30, 405–439 (1996). ArticleCAS Google Scholar
Coux, O., Tanaka, K. & Goldberg, A.L. Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem.65, 801–847 (1996). ArticleCAS Google Scholar
Leroy, E. et al. The ubiquitin pathway in Parkinson's disease. Nature395, 451–452 (1998). ArticleCAS Google Scholar
Polymeropoulos, M.H. et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science276, 2045–2047 (1997). ArticleCAS Google Scholar
Kruger, R. et al. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Genet.18, 106–108 (1998). ArticleCAS Google Scholar
Spillantini, M.G. et al. α-synuclein in Lewy bodies. Nature388, 839–840 (1997). ArticleCAS Google Scholar
Bennett, M.C. et al. Degradation of α-synuclein by proteasome. J. Biol. Chem.274, 33855–33858 (1999). ArticleCAS Google Scholar
Morett, E. & Bork, P. A novel transactivation domain in parkin. Trends Biochem. Sci.24, 229–231 (1999). ArticleCAS Google Scholar
Joazeiro, C.A.P. et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science286, 309–312 (1999). ArticleCAS Google Scholar
Xie, Y. & Varshavsky, A. The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain. EMBO J.18, 6832–6844 (1999). ArticleCAS Google Scholar
Harper, J.W. & Elledge, S.J. Skipping into the E2F1-destruction pathway. Nature Cell Biol.1, E5–E7 (1999). ArticleCAS Google Scholar
Deshaies, R.J. SCF and Cullin/RING-H2-based ubiquitin-ligases. Annu. Rev. Cell Dev. Biol.15, 435–467 (1999). ArticleCAS Google Scholar
Lorick, K.L. et al. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl Acad. Sci. USA96, 11364–11369 (1999). ArticleCAS Google Scholar
Moynihan, T.P. et al. The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. J. Biol. Chem.274, 30963–30968 (1999). ArticleCAS Google Scholar
Martinez-Noel, G., Niedenthal, R., Tamura, T. & Harbers, K. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett.454, 257–261 (1999). ArticleCAS Google Scholar
Hattori, N. et al. Point mutations (Thr240Arg and Gln311Stop) in the parkin gene. Biochem. Biophys. Res. Commun.249, 754–758 (1998). ArticleCAS Google Scholar
Rock, K.L. et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell78, 761–771 (1994). ArticleCAS Google Scholar
Suzuki, H. et al. IκBα ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, βTrCP1 and βTrCP2. Biochem. Biophys. Res. Commun.256, 127–132 (1999). ArticleCAS Google Scholar