The NOTCH4 locus is associated with susceptibility to schizophrenia (original) (raw)

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Nature Genetics volume 25, pages 376–377 (2000)Cite this article

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Abstract

Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A→G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.

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Acknowledgements

We thank H. Hillman, R. Masters and I. Kilbourn for the collection of blood samples from family members; and A. Gliddon, P. Douglas, V. Hanson and L. Hughes for help.

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Authors and Affiliations

1. Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bryn Hyfryd, The Crescent, Bangor, Gwynedd, UK
   Jun Wei & Gwynneth P. Hemmings

Authors

1. Jun Wei
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2. Gwynneth P. Hemmings
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Correspondence toJun Wei.

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Wei, J., Hemmings, G. The NOTCH4 locus is associated with susceptibility to schizophrenia .Nat Genet 25, 376–377 (2000). https://doi.org/10.1038/78044

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• Issue Date: August 2000
• DOI: https://doi.org/10.1038/78044

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