A point mutation in CD28 distinguishes proliferative signals from survival signals (original) (raw)
Lenschow, D. J., Walunas, T. L. & Bluestone, J. A. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol.14, 233–258 (1996). ArticleCAS Google Scholar
King, P. D. et al. Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK. J. Immunol.158, 580–590 (1997). CASPubMed Google Scholar
Raab, M. et al. p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: Implications for T-cell costimulation. Proc. Natl Acad. Sci. USA92, 8891–8895 (1995). ArticleCAS Google Scholar
Sadra, A. et al. Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells. J. Immunol.162, 1966–1973 (1999). CASPubMed Google Scholar
Pages, F. et al. Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling. Nature369, 327–329 (1994). ArticleCAS Google Scholar
Hutchcroft, J. E. & Bierer, B. E. Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins. Proc. Natl Acad. Sci. USA91, 3260–3264 (1994). ArticleCAS Google Scholar
Prasad, K. V. S. et al. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc. Natl Acad. Sci. USA.91, 2834–2838 (1994). ArticleCAS Google Scholar
Stein, P. H., Fraser, J. D. & Weiss, A. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3′-kinase. Mol. Cell. Biol.14, 3392–3402 (1994). ArticleCAS Google Scholar
Truitt, K. E., Hicks, C. M. & Imboden, J. B. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. J. Exp. Med.179, 1071–1076 (1994). ArticleCAS Google Scholar
August, A. & Dupont, B. CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase. Int. Immunol.6, 769–774 (1994). ArticleCAS Google Scholar
Schneider, H., Cai, Y.-C., Prasad, K. V. S., Shoelson, S. E. & Rudd, C. E. T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras. Eur. J. Immunol.25, 1044–1050 (1995). ArticleCAS Google Scholar
Vanhaesebroeck, B., Leevers, S. J., Panayotou, G. & Waterfield, M. D. Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends. Biochem. Sci.22, 267–272 (1997). ArticleCAS Google Scholar
Songyang, Z. et al. SH2 domains recognize specific phosphopeptide sequences. Cell72, 767–778 (1993). ArticleCAS Google Scholar
Vanhaesebroeck, B. & Waterfield, M. D. Signaling by distinct classes of phosphoinositide 3-kinases. Exp. Cell. Res.253, 239–254 (1999). ArticleCAS Google Scholar
Cai, Y. C. et al. Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation. Immunity3, 417–426 (1995). ArticleCAS Google Scholar
Ward, S. G., Wilson, A., Turner, L., Westwick, J. & Sansom, D. M. Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin. Eur. J. Immunol.25, 526–532 (1995). ArticleCAS Google Scholar
Lahesmaa, R. et al. Modulation of the Grb2-associated protein complex in human CD4+ T cells by receptor activation. J. Immunol.155, 3815–3822 (1995). CASPubMed Google Scholar
Zell, T., Hunt, S. R., Mobley, J. L., Finkelstein, L. D. & Shimizu, Y. CD28-mediated up-regulation of β1-integrin adhesion involves phosphatidylinositol 3-kinase. J. Immunol.156, 883–886 (1996). CASPubMed Google Scholar
Shi, J., Cinek, T., Truitt, K. E. & Imboden, J. B. Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen- mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells. J. Immunol.158, 4688–4695 (1997). CASPubMed Google Scholar
Collette, Y., Razanajaona, D., Ghiotto, M. & Olive, D. CD28 can promote T cell survival through a phosphatidylinositol 3- kinase-independent mechanism. Eur. J. Immunol.27, 3283–3289 (1997). ArticleCAS Google Scholar
Cefai, D. et al. CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation. J. Immunol.160, 2223–2230 (1998). CASPubMed Google Scholar
Crooks, M. E. C. et al. CD28-Mediated Costimulation in the Absence of Phosphatidylinositol 3-Kinase Association and Activation. Mol. Cell. Biol.15, 6820–6828 (1995). ArticleCAS Google Scholar
Truitt, K. E., Nagel, T., Suen, L. F. & Imboden, J. B. Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells. J. Immunol.156, 4539–4541 (1996). CASPubMed Google Scholar
Truitt, K. E. et al. CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. J. Immunol.155, 4702–4710 (1995). CASPubMed Google Scholar
Barz, C., Nagel, T., Truitt, K. E. & Imboden, J. B. Mutational analysis of CD28-mediated costimulation of Jun-N-terminal kinase and IL-2 production. J. Immunol.161, 5366–5372 (1998). CASPubMed Google Scholar
Lu, Y., Phillips, C. A. & Trevillyan, J. M. Phosphatidylinositol 3-kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor wortmannin. Eur. J. Immunol.25, 533–537 (1995). ArticleCAS Google Scholar
Ueda, Y. et al. Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion. Int. Immunol.7, 957–966 (1995). ArticleCAS Google Scholar
Ellis, J. H. et al. GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28. J. Immunol.164, 5805–5814 (2000). ArticleCAS Google Scholar
Kim, H. H., Tharayil, M. & Rudd, C. E. Growth factor receptor-bound protein 2 SH2/ SH3 domain binding to CD28 and its role in co-signaling. J. Biol. Chem.273, 296–301 (1998). ArticleCAS Google Scholar
Liu, S. K., Fang, N., Koretzky, G. A. & McGlade, C. J. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr. Biol.9, 67–75 (1999). ArticleCAS Google Scholar
Lee, N. A., Loh, D. Y. & Lacy, E. CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes in transgenic mice. J. Exp. Med.175, 1013–1025 (1992). ArticleCAS Google Scholar
Pages, F. et al. Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association. J. Biol. Chem.271, 9403–9409 (1996). ArticleCAS Google Scholar
Okkenhaug, K. & Rottapel, R. Grb2 Forms an Inducible Protein Complex with CD28 through a Src Homology 3 Domain-Proline Interaction. J. Biol. Chem.273, 21194–21202 (1998). ArticleCAS Google Scholar
Vanhaesebroeck, B. & Alessi, D. R. The PI3K-PDK1 connection: more than just a road to PKB. Biochem. J.346, 561–576 (2000). CASPubMedPubMed Central Google Scholar
Kundig, T. M. et al. Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity5, 41–52 (1996). ArticleCAS Google Scholar
Lucas, P. J., Negishi, I., Nakayama, K., Fields, L. E. & Loh, D. Y. Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol.154, 5757–5768 (1995). CASPubMed Google Scholar
Sperling, A. I. et al. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation. J. Immunol.157, 3909–3917 (1996). CASPubMed Google Scholar
Boise, L. H. et al. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL . Immunity3, 87–98 (1995). ArticleCAS Google Scholar
Shahinian, A. et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science261, 609–612 (1993). ArticleCAS Google Scholar
Ferguson, S. E., Han, S., Kelsoe, G. & Thompson, C. B. CD28 is required for germinal center formation. J. Immunol.156, 4576–4581 (1996). CASPubMed Google Scholar
Nishina, H. et al. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J. Exp. Med.186, 941–953 (1997). ArticleCAS Google Scholar
Dahl, A. M. et al. Expression of Bcl-XL restores cell survival, but not proliferation and effector differentiation, in CD28-deficient T lymphocytes. J. Exp. Med.191, 2031–2038 (2000). ArticleCAS Google Scholar
Jones, R. G. et al. Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-XL levels in vivo. J. Exp. Med.191, 1721–1734 (2000). ArticleCAS Google Scholar
Sasaki, T. et al. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration. Science287, 1040–1046 (2000). ArticleCAS Google Scholar
Fruman, D. A. et al. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science283, 393–397 (1999). ArticleCAS Google Scholar
Marengere, L. E. et al. The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28. J. Immunol.159, 3220–3229 (1997). CASPubMed Google Scholar
Yang, W. C., Ghiotto, M., Barbarat, B. & Olive, D. The role of Tec protein-tyrosine kinase in T cell signaling. J. Biol. Chem.274, 607–617 (1999). ArticleCAS Google Scholar