To live and let die (original) (raw)

Nature Immunology volume 2, pages 377–379 (2001)Cite this article

Adjuvants and inflammation inhibit TCR ligation-induced apoptosis of T cells. Bcl-3 may enhance the increased T cell survival by positive regulation of NF-κB transcription factors.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 print issues and online access

$209.00 per year

only $17.42 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: Intercellular signaling mechanisms that promote survival of antigen-stimulated T cells.

Bob Crimi

Figure 2: Growth factors (for example, IL-4, IL-7 and IL-9) also induce Bcl-3 expression in T cells, which leads to increased expression of NF-κB prosurvival target genes.

Bob Crimi

References

  1. Newton, K. & Strasser, A. Adv. Immunol. 76, 179–226 (2001).
    Article Google Scholar
  2. Mitchell, T. C. et al. Nature Immunol. 2, 397–402 (2001).
    Article CAS Google Scholar
  3. Bouillet, P. et al. Science 286, 1735–1738 (1999).
    Article CAS Google Scholar
  4. Strasser, A., Harris, A. W., Huang, D. C. S., Krammer, P. H. & Cory, S. EMBO J. 14, 6136–6147 (1995).
    Article CAS Google Scholar
  5. Gugasyan, R. et al. Immunol. Rev. 176, 134–140 (2000).
    Article CAS Google Scholar
  6. Richard, M., Louahed, J., Demoulin, J. B. & Renauld, J. C. Blood 93, 4318–4327 (1999).
    CAS PubMed Google Scholar
  7. Rebollo, A. et al. Mol. Cell Biol. 20, 3407–3426 (2000).
    Article CAS Google Scholar
  8. Franzoso, G. et al. Immunity 6, 479–490 (1997).
    Article CAS Google Scholar
  9. Schwarz, E. M., Krimpenfort, P., Berns, A. & Verma, I. M. Genes Dev. 11, 187–197 (1997).
    Article CAS Google Scholar
  10. Franzoso, G. et al. Nature 359, 339–342 (1992).
    Article CAS Google Scholar
  11. Kerr, L. D. et al. Genes Dev. 6, 2352–2363 (1992).
    Article CAS Google Scholar
  12. Ong, S. T. et al. Oncogene 16, 2333–2343 (1998).
    Article CAS Google Scholar
  13. Strasser, A., Harris, A. W., Bath, M. L. & Cory, S. Nature 348, 331–333 (1990).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. The Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, 3050 Vic, Australia
    Steve Gerondakis & Andreas Strasser

Authors

  1. Steve Gerondakis
    You can also search for this author inPubMed Google Scholar
  2. Andreas Strasser
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Gerondakis, S., Strasser, A. To live and let die.Nat Immunol 2, 377–379 (2001). https://doi.org/10.1038/87669

Download citation

This article is cited by