Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32) (original) (raw)

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References

1. Zucca, E., Roggero, E. & Pileri, S. B-cell lymphoma of MALT type: a review with special emphasis on diagnostic and management problems of low-grade gastric tumours. Br. J. Haematol. 100, 3– 14 (1998).
   Article CAS PubMed Google Scholar
2. Hofmann, K., Bucher, P. & Tschopp, J. The CARD domain: a new apoptotic signaling motif. Trends Biochem. Sci. 22, 155–156 (1997).
   Article CAS PubMed Google Scholar
3. Wotherspoon, A.C., Pan, L., Diss, T.C. & Isaacson, P.G. Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue. Cancer Genet. Cytogenet. 58, 35–38 (1992).
   Article CAS PubMed Google Scholar
4. Offit, K., Jhanwar, S.C., Ladanyi, M., Filippa, D.A. & Chaganti, R.S. Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment. Genes Chromosomes Cancer 3, 189–201 (1991).
   Article CAS PubMed Google Scholar
5. Tilly, H. et al. Prognostic value of chromosomal abnormalities in follicular lymphoma. Blood 84, 1043–1049 (1994).
   CAS PubMed Google Scholar
6. Schlegelberger, B. et al. Cytogenetic findings and results of combined immunophenotyping and karyotyping in Hodgkin's disease. Leukemia 8, 72–80 (1994).
   CAS PubMed Google Scholar
7. Telford, E.A.R., Watson, M.S., Aird, H.C., Perry, J. & Davison, A.J. The DNA sequence of equine herpesvirus 2. J. Mol. Biol. 249, 520–528 (1995).
   Article CAS PubMed Google Scholar
8. Cesarman, E. & Knowles, D.M. Kaposi's sarcoma-associated herpesvirus: a lymphotropic human herpesvirus associated with Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Semin. Diagn. Pathol. 14, 54–66 (1997).
   CAS PubMed Google Scholar
9. Chou, J.J., Matsuo, H., Duan, H. & Wagner, G. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell 94, 171– 180 (1998).
   Article CAS PubMed Google Scholar
10. Yan, M., Lee, J., Schilbach, S., Goddard, A. & Dixit, V. mE10, a novel CARD-containing proapoptotic molecule. J. Biol. Chem. 274, 10287– 10292 (1999).
    Article CAS PubMed Google Scholar
11. Yin, C., Knudson, M., Korsmeyer, S.J. & Van Dyke, T. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385, 637–640 ( 1997).
    Article CAS PubMed Google Scholar
12. Storb, U. Progress in understanding the mechanism and consequences of somatic hypermutation. Immunol. Rev. 162, 5–11 (1998).
    Article CAS PubMed Google Scholar
13. Shen, H.M., Peters, A., Baron, B., Zhu, X. & Storb, U. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 280, 1750–1752 (1998).
    Article CAS PubMed Google Scholar
14. Sonenshein, G.E. Rel/NF-κB transcription factors and the control of apoptosis. Semin. Cancer Biol. 8, 113–119 (1997).
    Article CAS PubMed Google Scholar
15. Wang, C.Y., Mayo, M.W., Korneluk, R.G., Goeddel, D.V. & Baldwin, A.S. Jr NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281, 1680–1683 (1998).
    Article CAS PubMed Google Scholar
16. Snow, E.C. The role of c-myc during normal B cell proliferation, and as B cells undergo malignant transformation. Curr. Top. Microbiol. Immunol. 224, 211–220 (1997).
    CAS PubMed Google Scholar
17. Mayo, M.W. et al. Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278, 1812–1815 (1997).
    Article CAS PubMed Google Scholar
18. Besancon, F., Atfi, A., Gespach, C., Cayre, Y.E. & Bourgeade, M.F. Evidence for a role of NF-κB in the survival of hematopoietic cells mediated by interleukin 3 and the oncogenic TEL/platelet-derived growth factor receptor β fusion protein. Proc. Natl Acad. Sci. USA 95, 8081–8086 ( 1998).
    Article CAS PubMed PubMed Central Google Scholar
19. Reuther, J.Y., Reuther, G.W., Cortez, D., Pendergast, A.M. & Baldwin, A.S. Jr A requirement for NF-κB activation in Bcr-Abl-mediated transformation. Genes Dev. 12, 968–981 ( 1998).
    Article CAS PubMed PubMed Central Google Scholar
20. Lee, H. et al. Role of the Rel-family of transcription factors in the regulation of c-myc gene transcription and apoptosis of WEHI 231 murine B-cells. Curr. Top. Microbiol. Immunol. 194, 247– 255 (1995).
    CAS PubMed Google Scholar
21. Baeuerle, P.A. & Baltimore, D. NF-κB: ten years after. Cell 87, 13– 20 (1996).
    Article CAS PubMed Google Scholar
22. Gerondakis, S., Grumont, R., Rourke, I. & Grossmann, M. The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation. Curr. Opin. Immunol. 10, 353– 359 (1998).
    Article CAS PubMed Google Scholar
23. Luque, I. & Gelinas, C. Rel/NF-κB and IκB factors in oncogenesis. Semin. Cancer Biol. 8, 103 –111 (1997).
    Article CAS PubMed Google Scholar
24. Willis, T.G. et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 96, 35–45 (1999).
    Article CAS PubMed Google Scholar
25. Willis, T.G. et al. Rapid molecular cloning of rearrangements of the IGHJ l ocus using long-distance inverse polymerase chain reaction. Blood 90, 2456–2464 ( 1997).
    CAS PubMed Google Scholar
26. Siebert, R. et al. Application of interphase fluorescence in situ hybridization for the detection of the Burkitt translocation t(8;14)(q24;q32) in B-cell lymphomas. Blood 91, 984– 990 (1998).
    CAS PubMed Google Scholar
27. McCarthy, J.V., Ni, J. & Dixit, V.M. RIP2 is a novel NF-κB-activating and cell death-inducing kinase. J. Biol. Chem. 273, 16968–16975 (1998).
    Article CAS PubMed Google Scholar

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Acknowledgements

We thank P. Vandiveer, I.S. Herrington and D. Dodson for manuscript preparation; D. Schuster, C. Becher and C. Reinsch for technical assistance; Y. Zhang, I.M. Subero and T. Springer for help with FISH studies; S. Gesk for assistance with analysis of the sequencing data; and J. Cleveland, J. Downing, G. Grosveld, J. Ihle, M. Kastan, A.T. Look and J. van Deursen for their comments regarding the manuscript. This research was supported in part by Cancer Center Support (CORE) Grant CA-27165 from the National Cancer Institute, the American Lebanese Syrian Associated Charities (ALSAC), St. Jude Children's Research Hospital, the Comité du Rhône de la Ligue Contre le Cancer (Lyon France), Deutsche Krebshilfe Grant 10-0992-Schl3, Wilhelm Sander Stiftung Grant 95.003.2 and the Interdisciplinary Center for Clinical Cancer Research, University of Kiel. B.S. holds a Hermann and Lilly Schilling professorship.

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Author notes

1. Quangeng Zhang, Reiner Siebert, Minhong Yan, Bernd Hinzmann and Xiaoli Cui: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Pathology and Laboratory Medicine, St. Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA
   Quangeng Zhang, Xiaoli Cui, Liquan Xue & Stephan W. Morris
2. Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA
   Stephan W. Morris
3. Center for Biotechnology, St. Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA
   Karen M. Rakestraw & Clayton W. Naeve
4. Department of Pediatrics, University of Tennessee, College of Medicine, Memphis, 38163, Tennessee, USA
   Stephan W. Morris
5. Department of Molecular Oncology, Genentech, Inc., South San Francisco, 94080, California, USA
   Minhong Yan & Vishva M. Dixit
6. metaGen Gesellschaft für Genomforschung mbH, Ihnestrasse 63, Berlin, D-14195, Germany
   Bernd Hinzmann, Georg Beckmann & André Rosenthal
7. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198-5440, Nebraska, USA
   Dennis D. Weisenburger
8. Department of Pediatrics, University of Nebraska Medical Center, Omaha, 68198-5440, Nebraska, USA
   Warren G. Sanger
9. Center for Human Genetics, University of Nebraska Medical Center, Omaha, 68198-5440, Nebraska, USA
   Warren G. Sanger
10. Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, Vienna, A-1140, Austria
    Hadwiga Nowotny
11. Jakob Erdheim Institute of Pathology, Hospital Lainz, Vienna, A-1130, Austria
    Michael Vesely
12. Laboratoire d' Hématologie, Centre Hospitalier Lyon-Sud-Université Claude Bernard, ierre-Bénite, 69495, France
    Evelyne Callet-Bauchu
13. Service d' Hématologie, Centre Hospitalier Lyon-Sud-Université Claude Bernard, ierre-Bénite, 69495, France
    Gilles Salles
14. Department of Human Genetics, University of Kiel, Kiel, D-24105, Germany
    Reiner Siebert & Brigitte Schlegelberger

Authors

1. Quangeng Zhang
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2. Reiner Siebert
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3. Minhong Yan
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4. Bernd Hinzmann
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5. Xiaoli Cui
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6. Liquan Xue
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7. Karen M. Rakestraw
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8. Clayton W. Naeve
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9. Georg Beckmann
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10. Dennis D. Weisenburger
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11. Warren G. Sanger
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12. Hadwiga Nowotny
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13. Michael Vesely
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14. Evelyne Callet-Bauchu
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15. Gilles Salles
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16. Vishva M. Dixit
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17. André Rosenthal
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18. Brigitte Schlegelberger
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19. Stephan W. Morris
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Corresponding authors

Correspondence toBrigitte Schlegelberger or Stephan W. Morris.

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Zhang, Q., Siebert, R., Yan, M. et al. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32) .Nat Genet 22, 63–68 (1999). https://doi.org/10.1038/8767

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• Received: 30 September 1998
• Accepted: 02 April 1999
• Issue Date: May 1999
• DOI: https://doi.org/10.1038/8767