Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1 (original) (raw)

References

1. Pani, A. & Marongiu, M.E. Anti-HIV-1 integrase drugs: How far from the shelf? Curr. Pharm. Des. 6, 569–584 (2000).
   Article CAS Google Scholar
2. Pommier, Y. & Neamati, N. Inhibitors of human immunodeficiency virus integrase. Adv. Virus Res. 52, 427–458 (1999).
   Article CAS Google Scholar
3. Mathe, C. & Nair, V. Potential inhibitors of HIV integrase. Nucleosides Nucleotides 18, 681–682 (1999).
   Article CAS Google Scholar
4. Asante-Appiah, E. & Skalka, A.M. Molecular mechanisms of retroviral DNA integration. Antiviral Res. 36, 139–156 (1997).
   Article CAS Google Scholar
5. Brown, P.O. Integration of retroviral DNA. Curr. Topics Microbiol. Immunol. 157, 19–48 (1990).
   CAS Google Scholar
6. Desrosiers, R.C. Strategies used by human immunodeficiency virus that allow persistent viral replication. Nature Med. 5, 723–725 (1999).
   Article CAS Google Scholar
7. Brown, P. Integration. in Retroviruses (eds. Coffin, J.M., Hughes, S.H. & Varmus, H.E.) 161–203 (Cold Spring harbor Laboratory Press, Cold Spring Harbor, New York, 1997).
   Google Scholar
8. Engleman, A., Englund, G., Orenstein, J.M., Martin, M.A. & Craigie, R. Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. J. Virol. 69, 2729–2736 (1995).
   Google Scholar
9. Masuda, T., Planelles, V., Krogstad, P. & Chen, I.S.Y. Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: Unusual phenotype of mutants in the zinc finger-like domain. J. Virol. 69, 6687–6696 (1995).
   CAS PubMed PubMed Central Google Scholar
10. Wu, X. et al. Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex. J. Virol. 73, 2126–2135 (1999).
    CAS PubMed PubMed Central Google Scholar
11. Leavitt, A.D., Robles, G., Alesandro, N. & Varmus, H.E. Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrase viral DNA efficiently during infection. J. Virol. 70, 721–728 (1996).
    CAS PubMed PubMed Central Google Scholar
12. Nakamura, T. et al. Lack of infectivity of HIV-1 integrase zinc finger-like domain mutant with morphologically normal maturation. Biochem. Biophys. Res. Commun. 239, 715–722 (1997).
    Article CAS Google Scholar
13. Kalpana, G.V., Marmon, S., Wang, W., Crabtree, G.R. & Goff, S.P. Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. Science 266, 2002–2006 (1994).
    Article CAS Google Scholar
14. Morozov, A., Yung, E. & Kalpana, G. Structure-function analysis of integrase interactor 1L1 reveals differential properties of two repeat motifs present in the highly conserved region. Proc. Natl. Acad. Sci. USA 95, 1120–1125 (1998).
    Article CAS Google Scholar
15. Versteege, I. et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Nature 394, 203–206 (1998).
    Article CAS Google Scholar
16. Biegel, J.A. et al. Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. Cancer Res. 59, 74–79 (1999).
    CAS PubMed Google Scholar
17. Wang, W. et al. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J. 15, 5370–82 (1996).
    Article CAS Google Scholar
18. Kingston, R.E. & Narlikar, G.J. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity. Genes Dev. 13, 2339–52 (1999).
    Article CAS Google Scholar
19. Naldini, L. et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272, 263–267 (1996).
    Article CAS Google Scholar
20. Leung, D.W., Chen, E. & Goeddel, D.V. A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction. Techique 1, 11–15 (1989).
    Google Scholar
21. Wu, X. et al. Functional RT and integrase incorporated into HIV-1 particles independently of the Gag/Pol precursor protein. EMBO J. 16, 5113–22 (1997).
    Article CAS Google Scholar
22. Adachi, A. et al. Generation and characterization of human immunodeficiency virus type 1 mutants. Arch. Virol. 117, 45–58 (1991).
    Article CAS Google Scholar
23. Ansari-Lari, M.A., Donehower, L.A. & Gibbs, R.A. Analysis of human immunodeficiency virus type 1 integrase mutants. Virol. 211, 332–335 (1995).
    Article CAS Google Scholar
24. Cannon, P.M., Wilson, M., Byles, E., Kingsman, S.M. & Kingsman, A.J. Human immunodeficiency virus type 1 integrase: Effect on viral replication of mutations at highly conserved residues. J. Virol. 68, 4768–4775 (1994).
    CAS PubMed PubMed Central Google Scholar
25. Gallay, P., Swingler, S., Song, J., Bushman, F. & Trono, D. HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Cell 83, 569–576 (1995).
    Article CAS Google Scholar
26. Stevenson, M., Stanwick, T.L., Dempsey, M.P. & Lamonica, C.A. HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J. 9, 1551–1560 (1990).
    Article CAS Google Scholar
27. Wiskerchen, M. & Muesing, M.A. Human immunodeficiency virus type 1 integrase: Effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells. J. Virol. 69, 376–386 (1995).
    CAS PubMed PubMed Central Google Scholar
28. Fletcher, T.M., 3rd et al. Complementation of integrase function in HIV-1 virions. EMBO J. 16, 5123–38 (1997).
    Article CAS Google Scholar
29. Muchardt, C., Sardet, C., Bourachot, B., Onufryk, C. & Yaniv, M. A human protein with homology to Saccharomyces cerevisiae SNF5 interacts with the potential helicase hbrm. Nucleic Acids Res. 23, 1127–32 (1995).
    Article CAS Google Scholar
30. Ott, D.E. et al. Cytoskeletal proteins inside human immunodeficiency virus type 1 virions. J. Virol. 70, 7734–7743 (1996).
    CAS PubMed PubMed Central Google Scholar
31. Bukovsky, A. & Gottlinger, H. Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease. J. Virol. 70, 6820–6825 (1996).
    CAS PubMed PubMed Central Google Scholar
32. Swanstrom, R. & Wills, J.W. Synthesis, assembly, and processing of viral proteins. in Retroviruses (eds. Coffin, J.M., Hughes, S.H. & Varmus, H.E.) 263–334 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1997).
    Google Scholar
33. Cheng, S.-W. G. et al. c-MYC interacts with INII/hSNF5 and requires the SWI/SNF complex for transactivation function. Nature Gen. 22, 102–105 (1999).
    Article CAS Google Scholar

Download references