Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev (original) (raw)

References

  1. Vaishnav, Y.N. & Wong-Staal, F. Biochemistry of AIDS. Annu. Rev. Biochem. 60, 577–630 (1991).
    Article CAS Google Scholar
  2. Cullen, B.R. Mechanism of action of regulatory proteins encoded by complex retroviruses. Microbiol. Rev. 56, 375– 394 (1992).
    CAS PubMed PubMed Central Google Scholar
  3. Myer, B.E. & Malim, M.H. The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes Dev. 8 , 1538–1547 (1994).
    Article Google Scholar
  4. Malim, M.H., Bohnlein, S., Hauber, J. & Cullen, B.R. –Functional dissection of the HIV-1 Rev trans-activator-derivation of a trans-dominant repressor of Rev protein. Cell 58, 205– 214 (1989).
    Article CAS Google Scholar
  5. Fischer, U., Huber, J., Boelens, W.C., Mattaj, I.W. & Luhrmann, R. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82, 475–483 ( 1995).
    Article CAS Google Scholar
  6. Malim, M.H. et al. Stable expression of transdominant Rev protein in human T cells inhibits Human Immunodeficiency Virus replication. J. Exp. Med. 176, 1197–1201 ( 1992).
    Article CAS Google Scholar
  7. Woffendin, C., Ranga, U., Yang, Z., Xu, L. & Nabel, G.J. Expression of a protective gene-prolongs survival of T cells in human immunodeficiency virus-infected patients. Proc. Natl. Acad. Sci. USA 93, 2889–94 (1996).
    Article CAS Google Scholar
  8. Ranga, U. et al. Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals. Proc. Natl. Acad. Sci. USA 95,1201–1206 (1998).
  9. Fornerod, M., Ohno, M., Yoshida, M. & Mattaj. I.W. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90, 1051–1060 (1997).
    Article CAS Google Scholar
  10. Neville, M., Stutz, F., Lee, M., Davis, L.I. & Rasbach, M. The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. Curr. Biol. 7, 767–775 ( 1997).
    Article CAS Google Scholar
  11. Bogerd, H.P., Fridell, R.A., Madore, S. & Cullen, B.R. Identification of a novel cellular factor for the Rev/Rex class of retroviral regulatory proteins. Cell 82, 485– 494 (1995).
    Article CAS Google Scholar
  12. Fritz, C.C., Zapp, M.L. & Green, M.R. A human nucleoporin-like protein that specifically interacts with Rev. Nature 376, 530-533 (1995).
    Article CAS Google Scholar
  13. Ruhl., M. et al. Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating transactivation. J. Cell Biol. 123, 1309– 1320 (1993).
    Article CAS Google Scholar
  14. Luo, Y., Yu, H. & Peterlin, B.M. Cellular protein modulates effects of human immunodefficiency virus type 1 Rev. J. Virol. 68, 3850– 3856 (1994).
    CAS PubMed PubMed Central Google Scholar
  15. Tange, T.O., Jensen, T.H. & Kjems, J. In vitro interaction between human immunodeficiency virus type 1 Rev protein and splicing factor ASF/SF2-associated protein, p32. J. Biol. Chem. 271, 10066– 10072 (1996).
    Article CAS Google Scholar
  16. Xu, Y., Reddy, T.R., Fischer, W. & Wong-Staal, F. A novel hnRNP specifically interacts with HIV-1 RRE RNA. J. Biomed. Sci. 3, 82–91 (1996).
    CAS PubMed Google Scholar
  17. Powell, D.M., Amaral, C.M., Wu, J.Y., Maniatis, T. & Greene, W.C. HIV Rev-dependent binding of SF2/ASF to the Rev response element: Possible role in Rev-mediated inhibition of HIV RNA splicing. Proc. Natl. Acad. Sci. USA. 94, 973– 978 (1997).
    Article CAS Google Scholar
  18. Taylor, S.J. & Shalloway. D. An RNA-binding protein associated with src through its SH2 and SH3 domains in mitosis. Nature 368, 867–871 (1994).
    Article CAS Google Scholar
  19. Fumagalli, S., Totty, N.F., Hsuan, J.J. & Courtneidge, S.A. A target for SRC in mitosis. Nature 368, 871– 874 (1994).
    Article CAS Google Scholar
  20. Resnick, R.J., Taylor, S.J., Lin, Q. & Shalloway, D. Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis. Oncogene 15, 1247–1253 (1997).
    Article CAS Google Scholar
  21. Chen, T., Damaj, B.B., Herrera, C., Lasko, P. & Richard, S. Self-association of the single-KH-domain family members Sam68, GRP33, GRD-1, and QK1: Role of the KH domain. Mol. Cell. Biol. 17, 5707–5718 ( 1997).
    Article CAS Google Scholar
  22. Ishidate, T. et al. Identification of a novel nuclear localization signal in Sam68. FEBS Letters 409, 237– 241 (1997).
    Article CAS Google Scholar
  23. Barlat, I. et al. A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain. J. Biol. Chem. 272, 3129–3132 (1997).
    Article CAS Google Scholar
  24. Bray, M. et al. A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent. Proc. Natl. Acad. Sci. USA. 91, 1256– 1260 (1994).
    Article CAS Google Scholar
  25. Lavinsky, R.M. et al. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc. Natl. Acad. Sci. USA 95, 2920–2925 (1998).
    Article CAS Google Scholar
  26. Sadaie, M.R., Benter, T. & Wong-Staal, F. Site-directed mutagenesis of two trans-regulatory genes (tat-III, trs) of HIV-1. Science 239, 910 –914 (1988).
    Article CAS Google Scholar
  27. Wolff, B., Sanglier, J-J. & Wang, Y. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem. Biol. 4, 139–147 (1997).
    Article CAS Google Scholar
  28. Diaz, J-J. et al. Post-transcriptional transactivation of human retroviral envelope glycoprotein expression by herpes simplex virus Us11 protein. Nature 379, 273–277( 1996).
    Article CAS Google Scholar
  29. Siomi, H., Matunis, M.J., Michael, W.M. & Dreyfuss, G. The pre-mRNA binding K protein contains a novel evolutionarily conserved motif. Nuc. Acid. Res. 21, 1193– 1198 (1993).
    Article CAS Google Scholar
  30. Cruz-Alvarez, M. & Pellicer, A. Cloning of a full-length complementary DNA for an Artemia salina glycine-rich protein. Structural relationship with RNA binding proteins. J. Biol. Chem . 262, 13377–13380 ( 1987).
    CAS PubMed Google Scholar
  31. Siomi, H., Matunis, M.J., Nussbaum, R.L. & Dreyfuss, G. The protein product of fragile X gene, FMR1, has characteristics of an RNA-binding protein. Cell 74, 291–298 (1993).
    Article CAS Google Scholar
  32. Jones, A.R. & Schedl, T. Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans, affect a conserved domain also found in Src-associated protein Sam68. Genes Dev. 9, 1491–1504 (1995).
    Article CAS Google Scholar
  33. Lin, Q., Taylor, S.J. & Shalloway, D. Specificity and determinants of Sam68 RNA binding. Implications for the biological function of K homology domains. J. Biol. Chem . 272, 27274–27280 ( 1997).
    Article CAS Google Scholar
  34. Yu, M., Poeschla, E. & Wong-Staal, F. Progress towards gene therapy for HIV infection. Gene Ther. 1, 13–26 ( 1994).
    CAS PubMed Google Scholar
  35. Woffendin, C. et al. Nonviral and viral delivery of a human immunodeficiency virus protective gene into primary human T cells. Proc. Natl. Acad. Sci. USA 91, 11581–11585 ( 1994).
    Article CAS Google Scholar
  36. Junker, U. et al. Inhibition of human immunodeficiency virus type 1 replication in myelomonocytic cells derived from retroviral vector-transduced peripheral blood progenitor cells. Hum. Gene Ther. 9, 333–340 (1998).
    Article CAS Google Scholar
  37. Seed, B. & Sheen, J.-Y. A simple phase-extraction assay for chloramphenicol acetyltransferase activity. Gene 67, 271–277 (1988).
    Article CAS Google Scholar
  38. Torchia, J. et al. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387, 677 –684 (1997).
    Article CAS Google Scholar
  39. Reddy, T.R., Tang, H., Li, X. & Wong-Staal. F. Functional interaction of HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4). Oncogene 14, 2785– 2792 (1997).
    Article CAS Google Scholar

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