A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria (original) (raw)

References

  1. Wilson, A.G. et al. An allelic polymorphism within the human tumor factor α promoter region is strongly associated with HLA A1, B8 and DR3 alleles. J. Exp. Med. 177, 557–560 (1993).
    Article CAS PubMed Google Scholar
  2. D'Alfonso, S. & Richiardi, P.M. A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics 39, 150–154 ( 1994).
    CAS PubMed Google Scholar
  3. Hamann, A., Mantzoros, C., Vidal-Puig, A. & Flier, J.S. Genetic variability in the TNF-α promoter is not associated with type II diabetes mellitus (NIDDM). Biochem. Biophys. Res. Commun. 211, 833–839 (1995).
    Article CAS PubMed Google Scholar
  4. McGuire, W., Hill, A.V.S., Allsopp, C.E.M., Greenwood, B.M. & Kwiatkowski, D. Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria. Nature 371, 508–511 ( 1994).
    Article CAS PubMed Google Scholar
  5. Cabrera, M. et al. Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. J. Exp. Med. 182, 1259–1264 (1995).
    Article CAS PubMed Google Scholar
  6. Nadel, S., Newport, M.J., Booy, R. & Levin, M. Variation in the tumor necrosis factor-α gene promoter region may be associated with death from meningococcal disease. J. Infect. Dis. 174 , 878–880 (1996).
    Article CAS PubMed Google Scholar
  7. Roy, S. et al. Tumor necrosis factor promoter polymorphism and susceptibility to lepromatous leprosy. J. Infect. Dis. 176, 530–532 (1997).
    Article CAS PubMed Google Scholar
  8. Conway, D.J. et al. Scarring trachoma is associated with polymorphism in the tumor necrosis factor α (TNF-α) gene promoter and with elevated TNF-α levels in tear fluid. Infect. Immun. 65, 1003–1006 (1997).
    CAS PubMed PubMed Central Google Scholar
  9. Moffatt, M.F. & Cookson, W.O.C.M. Tumour necrosis factor haplotypes and asthma. Hum. Mol. Genet. 6, 551– 554 (1997).
    Article CAS PubMed Google Scholar
  10. Wilson, A.G., Symons, J.A., McDowell, T.L., McDevitt, H.O. & Duff, G.W. Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation. Proc. Natl Acad. Sci. USA 94, 3195– 3199 (1997).
    Article CAS PubMed PubMed Central Google Scholar
  11. Brinkman, B.M.N., Zuijdgeest, D., Kaigzel, E.L., Breedveld, F.C. & Verweij, C.L. Relevance of the tumor necrosis factor α-308 promoter polymorphism in TNF α gene regulation. J. Inflamm. 46, 32–41 ( 1996).
    CAS Google Scholar
  12. Ziegler-Heitbrock, H.W.L. et al. Establishment of a human cell line (MonoMac 6) with characteristics of mature monocytes. Int. J. Cancer 41, 456–461 (1988).
    Article CAS PubMed Google Scholar
  13. Fletcher, C., Heintz, N. & Roeder, R.G. Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene. Cell 51, 773–781 ( 1987).
    Article CAS PubMed Google Scholar
  14. Herr, W. & Cleary, M.A. The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev. 9, 1679–1693 (1995).
    Article CAS PubMed Google Scholar
  15. Clark, I.A. Cell-mediated immunity in protection and pathology of malaria. Parasitol. Today 3, 300–305 (1987).
    Article CAS PubMed Google Scholar
  16. Kwiatkowski, D. Malarial toxins and the regulation of parasite density. Parasitol. Today 11, 206–212 ( 1995).
    Article CAS PubMed Google Scholar
  17. Grau, G.E. et al. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 237, 1210–1212 (1987).
    Article CAS PubMed Google Scholar
  18. Grau, G.E. et al. Tumor necrosis factor and disease severity in children with falciparum malaria. N. Engl. J. Med. 320, 1586–1591 (1989).
    Article CAS PubMed Google Scholar
  19. Hill, A.V.S. et al. Common West African HLA antigens are associated with protection from severe malaria. Nature 352, 595– 600 (1991).
    Article CAS PubMed Google Scholar
  20. Brinkman, B.M.N., Keet, I.P.M., Miedema, F., Verweij, C.L. & Klein, M.R. Polymorphisms within the human tumor necrosis factor-α promoter region in human immunodeficiency virus type-1 seropositive persons. J. Infect. Dis. 175, 188–190 (1997).
    Article CAS PubMed Google Scholar
  21. Kaushansky, K., Shoemaker, S.G., O'Rork, C.A. & McCarty, J.M. Coordinate regulation of multiple human lymphokine genes by Oct-1 and potentially novel 45 and 43 kDa polypeptides. J. Immunol. 152, 1812–1820 (1994).
    CAS PubMed Google Scholar
  22. Wu, G.D., Lai, E.J., Huang, N. & Wen, X. Oct-1 and CCAAT/enhancer-binding protein (C/EBP) bind to overlapping elements within the interleukin-8 promoter. The role of Oct-1 as a transcriptional repressor. J. Biol. Chem. 272, 2396–2403 ( 1997).
    Article CAS PubMed Google Scholar
  23. Berendt, A.R., Simmons, D.L., Tansey, J., Newbold, C.I. & Marsh, K. Intercellular adhesion molecule 1 is an endothelial cell adhesion receptor for Plasmodium falciparum. Nature 341, 57–59 (1989).
    Article CAS PubMed Google Scholar
  24. Newbold, C. et al. Receptor-specific adhesion and clinical disease in Plasmodium falciparum. Am. J. Trop. Med. Hyg. 57, 389 –398 (1997).
    Article CAS PubMed Google Scholar
  25. Fong, C.W., Siddiqui, A.H. & Mark, D.F. Identification and characterisation of a novel repressor site in the human tumor necrosis factor α gene. Nucleic Acids Res. 22, 1108–1114 ( 1994).
    Article CAS PubMed PubMed Central Google Scholar
  26. Brinkman, B.M.N. et al. Tumour necrosis factor α gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease. Br. J. Rheumatol. 36, 516–521 (1997).
    Article CAS PubMed Google Scholar
  27. Hohler, T. et al. A TNF-α promoter polymorphism is associated with juvenile onset psoriasis and psoriatic arthritis. J. Invest. Dermatol. 109, 562–565 (1997).
    Article CAS PubMed Google Scholar
  28. Zuckerkandl, E. Neutral and nonneutral mutations: the creative mix—evolution of complexity in gene interaction systems. J. Mol. Evol. 44, S2–S8 (1997).
    Article CAS PubMed Google Scholar
  29. Udalova, I.A., Knight, J.C., Vidal, V., Nedospasov, S.A. & Kwiatkowski, D. Complex NF-κB interactions at the distal tumor necrosis factor promoter region in human monocytes. J. Biol. Chem. 273, 21178–21186 ( 1998).
    Article CAS PubMed Google Scholar
  30. Schreiber, E., Matthias, P., Muller, M. & Schaffner, W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17, 6419 (1989).
    Article CAS PubMed PubMed Central Google Scholar
  31. Sandaltzopoulos, R. & Becker, P.B. Solid phase DNase I footprinting: quick and versatile. Nucleic Acids Res. 22, 1511–1515 (1994).
    Article CAS PubMed PubMed Central Google Scholar
  32. Hansen, S.K. et al. A novel complex between the p65 subunit of NF-κB and c-rel binds to a DNA element involved in phorbol ester induction of the human urokinase gene. EMBO J. 11, 205– 213 (1992).
    Article CAS PubMed PubMed Central Google Scholar
  33. Nordeen, S.K. Luciferase reporter gene vectors for analysis of promoters and enhancers. BioTechniques 6, 454–458 (1988).
    CAS PubMed Google Scholar
  34. Udalova, I.A., Turetskaya, R.L., Kuprash, D.V. & Nedospasov, S.A. Two-step activation of human TNF gene transcription in macrophages. Role of NF-κB/Rel family members in LPS activation. Dokl. Acad. Nauk 342, 413–417 ( 1995).
    CAS Google Scholar
  35. Stuber, F. et al. -308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter. J. Inflamm. 46, 42–50 (1996).
    CAS Google Scholar
  36. Shakhov, A.N., Collart, M.A., Vassalli, P., Nedospasov, S.A. & Jongeneel, C.V. κB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages. J. Exp. Med. 171, 35–47 ( 1990).
    Article CAS PubMed Google Scholar
  37. Snow, R.W. et al. Periodicity and space-time clustering of severe malaria on the coast of Kenya. Trans. R. Soc. Trop. Med. Hyg. 87, 386–390 (1993).
    Article CAS PubMed Google Scholar
  38. Molyneux, M.E., Taylor, T.E., Wirima, J.J. & Borgstein, A. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q. J. Med. 71, 441–459 (1989).
    CAS PubMed Google Scholar
  39. Lewontin, R.C. The interaction of selection and linkage. General considerations: heterotic models. Genetics 49, 49– 67 (1964).
    CAS PubMed PubMed Central Google Scholar

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