Acute hepatic porphyria and hepatocellular carcinoma (original) (raw)

Clinical Oncology/Epidemiology

British Journal of Cancer volume 57, pages 117–120 (1988)Cite this article

Abstract

In this study we examined the case histories of 163 living and 82 deceased adult Finnish patients with acute hepatic porphyria. There were 184 patients with acute intermittent porphyria and 61 patients with variegate porphyria. Among the 124 of the 163 living patients, who were traced 1984-1985, no hepatocellular carcinoma was found. Among the 82 deceased patients the cause of death was porphyria in 29 (36%), cardiovascular disease in 23 (29%) and hepatocellular carcinoma in 7 (9%). Of the 7 patients with hepatocellular carcinoma, 6 had acute intermittent porphyria and one had variegate porphyria. In acute hepatic porphyria, as compared with the total population, the calculated risk of hepatocellular carcinoma is increased 61-fold.

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Authors and Affiliations

  1. Third Department of Medicine, University of Helsinki, Finland
    R Kauppinen

Authors

  1. R Kauppinen
  2. P Mustajoki

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Kauppinen, R., Mustajoki, P. Acute hepatic porphyria and hepatocellular carcinoma.Br J Cancer 57, 117–120 (1988). https://doi.org/10.1038/bjc.1988.23

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