Evidence for the presence of two tumour-suppressor genes for hepatocellular carcinoma on chromosome 13q (original) (raw)
- Experimental Oncology
- Published: 01 August 1995
British Journal of Cancer volume 72, pages 383–385 (1995)Cite this article
- 154 Accesses
- 65 Citations
- 3 Altmetric
- Metrics details
Abstract
The concept that genetic changes accumulate during development and progression of cancer is widely accepted. Frequent allelic losses at chromosome 13q have been found in hepatocellular carcinomas (HCCs), and a known tumour-suppressor at 13q14, the retinoblastoma (RB) gene, is thought to be the target of those events. However, no strong evidence has emerged to support a significant role of RB during hepatocarcinogenesis. To investigate the minimal area(s) of loss on chromosome 13q in HCCs, we analysed DNAs isolated from 92 tumours for loss of heterozygosity (LOH) at 13 loci on chromosome 13q, using polymorphic microsatellite markers. In 30 (32.6%) of 92 cases we detected LOH for at least one locus on chromosome 13q and 20 revealed a partial or interstitial deletion of chromosome 13q. Deletion mapping of these 20 tumours indicated two separate commonly deleted regions: one was located in the region including RB and the other was located in the region including the BRCA2 locus. These findings suggest that at least one putative tumour-suppressor gene for HCC other than RB, possibly BRCA2, exists on chromosome 13q.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
Author information
Authors and Affiliations
- Laboratory of Molecular Medicine, University of Tokyo, Japan
T Kuroki
Authors
- T Kuroki
You can also search for this author inPubMed Google Scholar - Y Fujiwara
You can also search for this author inPubMed Google Scholar - S Nakamori
You can also search for this author inPubMed Google Scholar - S Imaoka
You can also search for this author inPubMed Google Scholar - T Kanematsu
You can also search for this author inPubMed Google Scholar - Y Nakamura
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Kuroki, T., Fujiwara, Y., Nakamori, S. et al. Evidence for the presence of two tumour-suppressor genes for hepatocellular carcinoma on chromosome 13q.Br J Cancer 72, 383–385 (1995). https://doi.org/10.1038/bjc.1995.342
- Issue Date: 01 August 1995
- DOI: https://doi.org/10.1038/bjc.1995.342