p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer? (original) (raw)
- Experimental Oncology
- Published: 01 January 1997
British Journal of Cancer volume 75, pages 87–93 (1997)Cite this article
- 260 Accesses
- 68 Citations
- Metrics details
Abstract
The expression of the p53 and Rb1 proteins was examined in an unselected consecutive series of 250 primary operable colorectal carcinomas with a mean follow-up of 4.3 years (range 43-77 months). The overall cancer-specific mortality was 34.8%, with 87 cancer deaths and 35 deaths as the result of other causes. Expression of p53 protein was identified in 152 of 250 (60.8%) cases, with expression of Rb1 protein in 207 of 250 (82.8%) cases. There was no association of p53 or Rb protein expression with patient age, sex, tumour site, tumour size, tumour type, tumour grade, peritumoral fibrosis, tumour lymphocytic infiltrate, nature of the tumour margin, extramural vascular invasion, number of lymph nodes or high apical lymph node involved or local peritoneal infiltration by tumour, Dukes' stage or Jass group. There was no difference in overall survival or recurrence-free survival for those cases that showed p53 expression or Rb1 protein expression compared with those cases showing absence of p53 or Rb1 protein expression, although patients with tumours showing aberrant (reduced) Rb1 protein expression demonstrated shorter recurrence-free survival and overall survival. The effect of 'aberrant' Rb1 protein expression and shorter recurrence-free and overall survival did not, however, achieve independent statistical significance. The results from this study would suggest that expression of p53 and Rb1 proteins does not appear be useful in determining the prognosis of operable colorectal cancer.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
Author information
Authors and Affiliations
- Department of Histopathology and Gloucester Gastroenterology Group, Gloucestershire Royal Hospital, UK
DN Poller
Authors
- DN Poller
You can also search for this author inPubMed Google Scholar - KJ Baxter
You can also search for this author inPubMed Google Scholar - NA Shepherd
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Poller, D., Baxter, K. & Shepherd, N. p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?.Br J Cancer 75, 87–93 (1997). https://doi.org/10.1038/bjc.1997.14
- Issue Date: 01 January 1997
- DOI: https://doi.org/10.1038/bjc.1997.14