Independent prognostic importance of microvessel density in endometrial carcinoma (original) (raw)
- Clinical Oncology
- Published: 01 April 1998
British Journal of Cancer volume 77, pages 1140–1144 (1998)Cite this article
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Abstract
Angiogenesis is thought to be an important factor for tumour growth and metastatic spread, and microvessel counts may provide useful prognostic information for several tumour types. To investigate the prognostic impact of angiogenesis in endometrial carcinoma patients, the intratumour microvessel density, which was determined immunohistochemically, has been related to survival. Sixty patients with endometrial carcinoma with long (median 19 years) and complete follow-up have been studied. Patients with increased mean microvessel density (MVDmean > 68 mm2) had a significantly shorter 5-year survival compared with the rest (57% vs 90%, P = 0.004). In multivariate survival analyses, MVDmean had an independent prognostic impact (P = 0.03) when FIGO stage, histological type, histological grade as well as nuclear p53 protein expression was adjusted for. These findings indicate that intratumour microvessel density may contribute additional prognostic information to that obtained from the known risk factors and may be helpful in identifying endometrial carcinoma patients at high risk for disease progression.
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Authors and Affiliations
- Department of Gynaecology and Obstetrics, The Gade Institute, Haukeland University Hospital, Bergen, Norway
HB Salvesen
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- HB Salvesen
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Salvesen, H., Iversen, O. & Akslen, L. Independent prognostic importance of microvessel density in endometrial carcinoma.Br J Cancer 77, 1140–1144 (1998). https://doi.org/10.1038/bjc.1998.189
- Issue Date: 01 April 1998
- DOI: https://doi.org/10.1038/bjc.1998.189
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