Diversity of γδ T-cell antigens (original) (raw)

• Chien YH, Jores R, Crowley MP . Recognition by γ/δ T cells. Annu Rev Immunol 1996; 14: 511–532.
  Article CAS PubMed Google Scholar
• Haas W, Pereira P, Tonegawa S . γ/δ T cells. Annu Rev Immunol 1993; 11: 637–685.
  Article CAS PubMed Google Scholar
• Davis MM, Bjorkman PJ . T cell antigen receptor genes and T cell recognition. Nature 1988; 334: 395–402.
  Article CAS PubMed Google Scholar
• Asarnow DM, Kuziel WA, Bonyhadi M, Tigelaar RE, Tucker PW, Allison JP . Limited diversity of γδ antigen receptor genes of Thy-1+ dendritic epidermal cells. Cell 1988; 55: 837–847.
  Article CAS PubMed Google Scholar
• Hohlfeld R, Engel AG, Ii K, Harper MC . Polymyositis mediated by T lymphocytes that express that γ/δ receptor. N Engl J Med 1991; 324: 877–881.
  Article CAS PubMed Google Scholar
• Roark CL, French JD, Taylor MA, Bendele AM, Born WK, O'Brien RL . Exacerbation of collagen-induced arthritis by oligoclonal, iL-17-producing γδ T cells. J Immunol 2007; 179: 5576–5583.
  Article CAS PubMed Google Scholar
• Havran W, Allison JP . Developmentally ordered appearance of thymocytes expressing different T cell antigen receptors. Nature 1988; 335: 443–445.
  Article CAS PubMed Google Scholar
• O'Brien RL, Roark CL, Jin N, Aydintug MK, French JD, Chain JL et al. γδ T cell receptors: functional correlations. Immunol Rev 2007; 215: 77–88.
  Article CAS PubMed Google Scholar
• Jin N, Roark CL, Miyahara N, Taube C, Aydintug MK, Wands JM et al. Allergic airway hyperresponsiveness-enhancing γδ T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells. J Immunol 2009; 182: 2002–2010.
  Article CAS PubMed Google Scholar
• Narayan K, Sylvia KE, Malhotra N, Yin CC, Martens G, Vallerskog T et al. Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes. Nature Immunol 2012; 13: 511–518
  Article CAS Google Scholar
• Haas JD, Ravens S, Duber S, Sandrock I, Oberdorfer L, Kashani E et al. Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave. Immunity 2012; 37: 48–59.
  Article CAS PubMed Google Scholar
• Bonneville M, O'Brien RL, Born WK . γδ T cell effector functions: a blend of innate programming and acquired plasticity. Nat Rev Immunol 2010; 10: 467–478.
  Article CAS PubMed Google Scholar
• Hayes SM, Love PE . Distinct structure and signalling potential of the γδ TCR complex. Immunity 2002; 16: 1–20.
  Article Google Scholar
• Hayes SM, Li L, Love PE . TCR signal strength influences αβ/γδ lineage fate. Immunity 2005; 22: 583–593.
  Article CAS PubMed Google Scholar
• Rock EP, Sibbald PR, Davis MM, Chien YH . CDR3 length in antigen-specific immune receptors. J Exp Med 1994; 179: 323–328.
  Article CAS PubMed Google Scholar
• Born W, Cady C, Jones-Carson J, Mukasa A, Lahn M, O'Brien R . Immunoregulatory functions of γδ T cells. Adv Immunol 1999; 71: 77–144.
  Article CAS PubMed Google Scholar
• Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR et al. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity 1995; 3: 495–507.
  Article CAS PubMed Google Scholar
• Cady CT, Lahn M, Vollmer M, Tsuji M, Seo SJ, Reardon CL et al. Response of murine γδ T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 2000; 165: 1790–1798.
  Article CAS PubMed Google Scholar
• Zhang L, Jin N, Nakayama M, O'Brien RL, Eisenbarth GS, Born WK . γδ T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23. J Autoimmun 2010; 34: 478–484.
  Article CAS PubMed PubMed Central Google Scholar
• Blackman M, Yague J, Kubo R, Gay D, Coleclough C, Palmer E et al. The T cell recpertoire may be biased in favor of MHC recognition. Cell 1986; 47: 349–357.
  Article CAS PubMed Google Scholar
• Garcia KC, Gapin L, Adams JJ, Birnbaum ME, Scott-Browne JP, Kappler JW et al. A closer look at TCR germline recongition. Immunity 2012; 36: 887–888.
  Article CAS PubMed PubMed Central Google Scholar
• Adams EJ, Strop P, Shin S, Chien YH, Garcia KC . An autonomous CDR3δ is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by γδ T cells. Nat Immunol 2008; 9: 777–784.
  Article CAS PubMed PubMed Central Google Scholar
• Boyden LM, Lewis JM, Barbee SD, Bas A, Girardi M, Hayday AC et al. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells. Nat Genet 2008; 40: 656–662.
  Article CAS PubMed PubMed Central Google Scholar
• Born WK, O'Brien RL . Antigen-restricted γδ T-cell receptors? Arch Immunol Ther Exp (Warsz) 2009; 57: 129–135
  Article CAS Google Scholar
• Matis LA, Cron R, Bluestone JA . Major histocompatibility complex-linked specificity of γδ receptor-bearing T lymphocytes. Nature 1987; 330: 262–264.
  Article CAS PubMed Google Scholar
• Matis LA, Fry AM, Cron RQ, Cotterman MM, Dick RF, Bluestone JA . Structure and specificity of a class II alloreactive γδ T cell receptor heterodimer. Science 1989; 245: 746–749.
  Article CAS PubMed Google Scholar
• Wingren C, Crowley MP, Degano M, Chien YH, Wilson IA . Crystal structure of a γδ T cell receptor ligand T22: a truncated MHC-like fold. Science 2000; 287: 310–314.
  Article CAS PubMed Google Scholar
• Adams EJ, Chien YH, Garcia KC . Structure of a γδ T cell receptor in complex with the nonclassical MHC T22. Science 2005; 308: 227–231.
  Article CAS PubMed Google Scholar
• Shin S, El-Diwany R, Schaffert S, Adams EJ, Garcia KC, Pereira P et al. Antigen recognition determinants of γδ T cell receptors. Science 2005; 308: 252–255.
  Article CAS PubMed Google Scholar
• Hampl J, Schild H, Litzenberger C, Baron M, Crowley MP, Chien YH . The specificity of a weak γδ TCR interaction can be modulated by the glycosylation of the ligand. J Immunol 1999; 163: 288–294.
  CAS PubMed Google Scholar
• Sugita M, Brenner MB . T lymphocyte recognition of human group 1 CD1 molecules: implications for innate and acquired immunity. Semin Immunol 2000; 12: 511–516.
  Article CAS PubMed Google Scholar
• Das H, Sugita M, Brenner MB . Mechanisms of Vδ1 γδ T cell activation by microbial components. J Immunol 2004; 172: 6578–6586.
  Article CAS PubMed Google Scholar
• Cui Y, Kang L, Cui L, He W . Human γδ T cell recognition of lipid A is predominately presented by CD1b or CD1c on dendritic cells. Biol Direct 2009; 4: 47–58.
  Article CAS PubMed PubMed Central Google Scholar
• Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L et al. Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med 2005; 202: 295–308.
  Article CAS PubMed PubMed Central Google Scholar
• Russano AM, Agea E, Corazzi L, Postle AD, de Libero G, Porcelli SA et al. Recognition of pollen-derived phosphatidyl-ethanolamine by human CD1d-restricted gamma delta T cells. J Allergy Clin Immunol 2006; 117: 1178–1184.
  Article CAS PubMed Google Scholar
• Dieude M, Striegl H, Tyznik AJ, Wang J, Behar SM, Piccirillo CA et al. Cardiolipin binds to CD1d and stimulates CD1d-restricted γδ T cells in the normal murine repertoire. J Immunol 2011; 186: 4771–4781.
  Article CAS PubMed Google Scholar
• Huber S, Sartini D, Exley M . Role of CD1d in Coxsackievirus B3-induced myocarditis. J Immunol 2003; 170: 3147–3153.
  Article CAS PubMed Google Scholar
• Gapin L . iNKT cell autoreactivity: what is ‘self’ and how is it recognized? Nat Rev Immunol 2010; 10: 272–277.
  Article CAS PubMed PubMed Central Google Scholar
• Russano AM, Bassotti G, Agea E, Bistoni O, Mazzocchi A, Morelli A et al. CD1-restricted recognition of exogenous and self-lipid antigens by duodenal γδ+ T lymphocytes. J Immunol 2007; 178: 3620–3626.
  Article CAS PubMed Google Scholar
• Bai L, Picard D, Anderson B, Chaudhary V, Luoma A, Jabri B et al. The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR. Eur J Immunol 2012; 42: 2505–2510.
  Article CAS PubMed PubMed Central Google Scholar
• Groh V, Steinle A, Bauer S, Spies T . Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 1998; 279: 1737–1740.
  Article CAS PubMed Google Scholar
• Steinle A, Groh V, Spiess T . Diversification, expression, and γδ T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules. Proc Natl Acad Sci U S A 1998; 95: 12510–12515.
  Article CAS PubMed PubMed Central Google Scholar
• Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T . Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc Natl Acad Sci U S A 1999; 96: 6879–6884.
  Article CAS PubMed PubMed Central Google Scholar
• Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999; 285: 727–729.
  Article CAS PubMed Google Scholar
• Das H, Groh V, Kuiji C, Sugita M, Morita CT, Spies T et al. MICA engagement by human Vγ2Vδ2 T cells enhances their antigen-dependent effector function. Immunity 2001; 15: 83–93.
  Article CAS PubMed Google Scholar
• Wu J, Groh V, Spies T . T cell antigen receptor engagement and specificty in the recognition of stress-inducible MHC class I-related chains by human epithelial γδ T cells. J Immunol 2002; 169: 1236–1240.
  Article CAS PubMed Google Scholar
• Xu B, Pizarro JC, Holmes MA, McBeth C, Groh V, Spies T et al. Crystal structure of a γδ T-cell receptor specific for the human MHC class I homolog MICA. Proc Natl Acad Sci U S A 2011; 108: 2414–2419.
  Article CAS PubMed PubMed Central Google Scholar
• Scotet E, Martinez LO, Grant E, Barbaras R, Jeno P, Saulquin X et al. Tumor recognition following Vγ9Vδ2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-1. Immunity 2005; 22: 71–80.
  Article CAS PubMed Google Scholar
• Born WK, Vollmer M, Reardon C, Matsuura E, Voelker DR, Giclas PC et al. Hybridomas expressing γδ T-cell receptors respond to cardiolipin and β2-glycoprotein 1 (apolipoprotein H). Scand J Immunol 2003; 58: 374–381.
  Article CAS PubMed Google Scholar
• Fisch P, Malkovsky M, Braakman E, Sturm E, Bolhuis RLH, Prieve A et al. γ/δ T-cell clones and natural killer-cell clones mediate distinct patterns of non-major histocompatibility complex-restricted cytolysis. J Exp Med 1990; 171: 1567–1579.
  Article CAS PubMed Google Scholar
• Fisch P, Malkovsky M, Kovats S, Sturm E, Braakman E, Klein BS et al. Recognition by human Vγ9/Vδ2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells. Science 1990; 250: 1269–1273.
  Article CAS PubMed Google Scholar
• Fisch P, Oettel K, Fudim N, Surfus JE, Malkovsky M, Sondel PM . MHC-unrestricted cytotoxic and proliferative responses of two distinct human γ/δ T cell subsets to Daudi cells. J Immunol 1992; 148: 2315–2323.
  CAS PubMed Google Scholar
• Aydintug MK, Roark CL, Yin X, Wands JM, Born WK, O'Brien RL . Detection of cell surface ligands for the γδ TCR using soluble TCRs. J Immunol 2004; 172: 4167–4175.
  Article CAS PubMed Google Scholar
• Aydintug MK, Roark CL, Chain JL, Born WK, O'Brien RL . Macrophages express multiple ligands for γδ TCRs. Mol Immunol 2008; 45: 3253–3263.
  Article CAS PubMed PubMed Central Google Scholar
• Kozbor D, Trinchieri G, Monos DS, Isobe M, Russo G, Haney JA et al. Human TCR-γ+/δ+, CD8+ T lymphocytes recognize tetanus toxoid in an MHC-restricted fashion. J Exp Med 1989; 169: 1847–1851.
  Article CAS PubMed Google Scholar
• Kozbor D, Cassatella MA, Lessin S, Kagan J, Finver S, Faust J et al. Expression and function of γδ- and αβ-T cell receptor heterodimers on human somatic T cell hybrids. J Immunol 1990; 144: 3677–3683.
  CAS PubMed Google Scholar
• Rust CJJ, Verreck F, Vietor H, Koning F . Specific recognition of staphylococcal enterotoxin A by human T cells bearing receptors with the Vγ9 region. Nature 1990; 346: 572–574.
  Article CAS PubMed Google Scholar
• Guo Y, Ziegler HK, Safley SA, Niesel DW, Vaidya S, Klimpel GR . Human T-cell recognition of Listeria monocytogenes: recognition of listeriolysin O by TcRαβ+ and TcRγδ+ T cells. Infect Immunol 1995; 63: 2288–2294.
  CAS Google Scholar
• Rust CJJ, Koning F . γδ T cell reactivity towards bacterial superantigens. Semin Immunol 1993; 5: 41–46.
  Article CAS PubMed Google Scholar
• Skeen MJ, Ziegler HK . Intercellular interactions and cytokine responsiveness of peritoneal α/β and γ/δ T cells from _Listeria_-infected mice: synergistic effects of interleukin 1 and 7 on γ/δ T cells. J Exp Med 1993; 178: 985–996.
  Article CAS PubMed Google Scholar
• Fu YX, Roark CE, Kelly K, Drevets D, Campbell P, O'Brien R et al. Immune protection and control of inflammatory tissue necrosis by γδ T cells. J Immunol 1994; 153: 3101–3115.
  CAS PubMed Google Scholar
• O'Brien RL, Xiang Y, Huber S, Ikuta K, Born WK . Depletion of a γδ T cell subset can increase host resistance to a bacterial infection. J Immunol 2000; 165: 6472–6479.
  Article CAS PubMed Google Scholar
• Ryan-Payseur B, Frencher J, Shen L, Chen CY, Huang D, Chen ZW . Multieffector-functional immune responses of HMBPP-specific Vγ2Vδ2 T cells in non-human primates inoculated with Listeria monocytogenes DeltaactA prfA. J Immunol 2012; 189: 1285–1293.
  Article CAS PubMed Google Scholar
• Holoshitz J, Koning F, Coligan JE, de Bruyn J, Strober S . Isolation of CD4−CD8− mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 1989; 339: 226–229.
  Article CAS PubMed Google Scholar
• Janis EM, Kaufmann SHE, Schwartz RH, Pardoll DM . Activation of γδ T cells in the primary immune response to Mycobacterium tuberculosis. Science 1989; 244: 713–716.
  Article CAS PubMed Google Scholar
• O'Brien RL, Happ MP, Dallas A, Palmer E, Kubo R, Born WK . Stimulation of a major subset of lymphocytes expressing T cell receptor γδ by an antigen derived from Mycobacterium tuberculosis. Cell 1989; 57: 667–674.
  Article CAS PubMed Google Scholar
• Happ MP, Kubo RT, Palmer E, Born WK, O'Brien RL . Limited receptor repertoire in a mycobacteria-reactive subset of γδ T lymphocytes. Nature 1989; 342: 696–698.
  Article CAS PubMed Google Scholar
• Bitter W, Houben ENG, Bottai D, Brodin P, Brown EJ, Cox JS et al. Systematic genetic nomenclature for type VII secretion systems. PLOS Pathog 2009; 5: 1–6, e1000507.
  Article CAS Google Scholar
• Bottai D, Mailessi L, Simeone R, Friqui W, Laurent C, Lenormand P et al. ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis. J Infect Dis 2011; 203: 1155–1164.
  Article CAS PubMed Google Scholar
• Rhodes SG, Buddle BM, Hewinson RG, Vordermaier HM . Bovine tuberculosis: immune responses in the peripheral blood and at the site of active disease. Immunology 2000; 99: 195–202.
  Article CAS PubMed PubMed Central Google Scholar
• Welsh MD, Kennedy HE, Smyth AJ, Girvin RM, Andersen P, Pollock JM . Responses of bovine WC1+γδ T cells to protein and nonprotein antigens of Mycobacterium bovis. Infect Immun 2002; 70: 6114–6120.
  Article CAS PubMed PubMed Central Google Scholar
• Maue AC, Waters WR, Davis WC, Palmer MV, Minion FC, Estes DM . Analysis of immune responses directed toward a recombinant early secretory antigenic target six-kilodalton protein-culture filtrate protein 10 fusion protein in Mycobacterium bovis infected cattle. Infect Immun 2005; 73: 6659–6667.
  Article CAS PubMed PubMed Central Google Scholar
• Gioia C, Agrati C, Goletti D, Vincenti D, Carrara S, Amicosante M et al. Different cytokine production and effector/memory dynamics of αβ+ or γδ+ T-cell subsets in the peripheral blood of patients with active pulmonary tuberculosis. Int J Immunopathol Pharmacol 2003; 16: 247–252.
  Article CAS PubMed Google Scholar
• Li L, Wu CY . CD4+CD25+ Treg cells inhibit human memory γδ T cells to produce IFN-γ in response to M. tuberculosis antigen ESAT-6. Blood 2008; 111: 5629–5636.
  Article CAS PubMed Google Scholar
• Casetti R, Martino A, Sacchi A, Agrati C, Goletti D, Martini F . Do human γδ T cells respond to M. tuberculosis protein antigens? Blood 2008; 112: 4776.
  Article CAS PubMed Google Scholar
• Li L, Wu CY . Human memory but not naive γδ T cells from TST-positive individuals respond to M. tuberculosis antigen. Blood 2008; 112: 4777.
  Article CAS Google Scholar
• Cendron D, Ingoure S, Martino A, Casetti R, Horand F, Romagne F et al. A tuberculosis vaccine based on phosphoantigens and fusion proteins induces distinct γδ and αβ T cell responses in primates. Eur J Immunol 2007; 37: 549–565.
  Article CAS PubMed Google Scholar
• Sciammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA . T cell receptor-γ/δ cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J Exp Med 1997; 185: 1969–1975.
  Article CAS PubMed PubMed Central Google Scholar
• Johnson RM, Lancki DW, Sperling AI, Dick RF, Spear PG, Fitch FW et al. A murine CD4−, CD8− T cell receptor-γδ T lymphocyte clone specific for Herpes simplex virus glycoprotein I. J Immunol 1992; 148: 983–988.
  CAS PubMed Google Scholar
• Sciammas R, Johnson RM, Sperling AI, Brady W, Linsley PS, Spear PG et al. Unique antigen recognition by a herpsevirus-specific TCR-γδ cell. J Immunol 1994; 152: 5392–5397.
  CAS PubMed Google Scholar
• Born W, Hall L, Dallas A, Boymel J, Shinnick T, Young D et al. Recognition of a peptide antigen by heat shock reactive γδ T lymphocytes. Science 1990; 249: 67–69.
  Article CAS PubMed Google Scholar
• Sciammas R, Bluestone JA . HSV-1 glycoprotein I-reactive TCRγδ cells directly recognize the peptide backbone in a conformationally dependent manner. J Immunol 1998; 161: 5187–5192.
  CAS PubMed Google Scholar
• Sciammas R, Bluestone JA . TCRγδ cells and viruses. Microbes Infect 1999; 1: 203–212.
  Article CAS PubMed Google Scholar
• Wright A, Lee JE, Link MP, Smith SD, Carroll W, Levy R et al. Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor δ chain. J Exp Med 1989; 169: 1557–1564.
  Article CAS PubMed Google Scholar
• Kim HT, Nelson EL, Clayberger C, Sanjanwala M, Sklar J, Krensky AM . γδ T cell recognition of tumor Ig peptide. J Immunol 1995; 154: 1614–1623.
  CAS PubMed Google Scholar
• Pluschke G, Rüegg D, Hohlfeld R, Engel AG . Autoaggressive myocytotoxic T lymphocytes expressing an unusual γ/δ T cell receptor. J Exp Med 1992; 176: 1785–1789.
  Article CAS PubMed Google Scholar
• Wiendl H, Malotka J, Holzwarth B, Weltzien HU, Wekerle H, Hohlfeld R et al. An autoreactive γδ TCR derived from a polymyositis lesion. J Immunol 2002; 169: 515–521.
  Article CAS PubMed Google Scholar
• Dornmair K, Schneider CK, Malotka J, Dechant G, Wiendl H, Hohlfeld R . Antigen recongition properties of a Vγ1.3Vδ2-T-cell receptor from a rare variant of polymyositis. J Neuroimmunol 2004; 152: 168–175.
  Article CAS PubMed Google Scholar
• Bruder J, Siewert K, Obermeier B, Malotka J, Scheinert P, Kellermann J et al. Target specificity of an autoreactive pathogenic human γδ-T cell receptor in myositis. J Biol Chem 2012; 287: 20986–20995.
  Article CAS PubMed PubMed Central Google Scholar
• Born WK, Zhang L, Nakayama M, Jin N, Chain JL, Huan Y et al. Peptide antigens for γδ T cells. Cell Mol Life Sci 2011; 68: 2335–23343.
  Article CAS PubMed Google Scholar
• Fu YX, Kersh G, Vollmer M, Kalataradi H, Heyborne K, Reardon C et al. Structural requirements for peptides that stimulate a subset of γδ T cells. J Immunol 1994; 152: 1578–1588.
  CAS PubMed Google Scholar
• O'Brien RL, Fu YX, Cranfill R, Dallas A, Reardon C, Lang J et al. Heat shock protein Hsp-60 reactive γδ cells: a large, diversified T lymphocyte subset with highly focused specificity. Proc Natl Acad Sci U S A 1992; 89: 4348–4352.
  Article CAS PubMed PubMed Central Google Scholar
• Blond-Elguindi S, Cwirla SE, Dower WJ, Lipshutz RJ, Sprang SR, Sambrook JF et al. Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP. Cell 1993; 75: 717–728.
  Article CAS PubMed Google Scholar
• Mohan JF, Levisetti MG, Calderon B, Herzog JW, Petzold SJ, Unanue ER . Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes. Nat Immunol 2010; 4: 350–354.
  Article CAS Google Scholar
• Zhang L, Nakayama M, Eisenbarth GS . Insulin as an autoantigen in NOD/human diabetes. Curr Opin Immunol 2008; 20: 111–118.
  Article CAS PubMed PubMed Central Google Scholar
• Holoshitz J, Vila LM, Keroack BJ, McKinley DR, Bayne NK . Dual antigenic recognition by cloned human γδ T cells. J Clin Invest 1992; 89: 308–314.
  Article CAS PubMed PubMed Central Google Scholar
• Vidovic D, Roglic M, McKune K, Guerder S, MacKay C, Dembic Z . Qa-1 restricted recognition of foreign antigen by a γδ T-cell hybridoma. Nature 1989; 340: 646–650.
  Article CAS PubMed Google Scholar
• Modlin RL, Pirmez C, Hofman FM, Torigian V, Uyemura K, Rea TH et al. Lymphocytes bearing antigen-specific γδ T-cell receptors in human infectious disease lesions. Nature 1989; 339: 544–548.
  Article CAS PubMed Google Scholar
• Kabelitz D, Bender A, Schondelmaier S, Schoel B, Kaufmann SHE . A large fraction of human peripheral blood γδ+ T cells is activated by Mycobacterium tuberculosis but not by its 65 kD heat shock protein. J Exp Med 1990; 171: 667–679.
  Article CAS PubMed Google Scholar
• Pfeffer K, Schoel B, Gulle H, Kaufmann SHE, Wagner H . Primary responses to human T cells to mycobacteria: a frequent set of γ/δ T cells are stimulated by protease-resistant ligands. Eur J Immunol 1990; 20: 1175–1179.
  Article CAS PubMed Google Scholar
• Constant P, Davodeau F, Peyrat MA, Poquet Y, Puzo G, Bonneville M et al. Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands. Science 1994; 264: 267–270.
  Article CAS PubMed Google Scholar
• Tanaka Y, Sano S, Nieves E, de Libero G, Rosa D, Modlin RL et al. Nonpeptide ligands for human γδ T cells. Proc Natl Acad Sci U S A 1994; 91: 8175–8179.
  Article CAS PubMed PubMed Central Google Scholar
• Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB, Bloom BR . Natural and synthetic non-peptide antigens recognized by human γδ T cells. Nature 1995; 375: 155–158.
  Article CAS PubMed Google Scholar
• Hintz M, Reichenberg A, Altincicek B, Bahr U, Gschwind RM, Kollas AK et al. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human γδ T cells in Escherichia coli. FEBS Lett 2001; 509: 317–322.
  Article CAS PubMed Google Scholar
• Wang H, Fang Z, Morita C . Vγ2Vδ2 T cell receptor recognition of prenyl pyrophosphates is dependent on all CDRs. J Immunol 2010; 184: 6209–6222.
  Article CAS PubMed Google Scholar
• Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y et al. Photoaffinity antigens for human γδ T cells. J Immunol 2008; 181: 7738–7750.
  Article CAS PubMed Google Scholar
• Wei H, Huang D, Lai X, Chen M, Zhong W, Wang R et al. Definition of APC presentation of phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate to Vγ2Vδ2 TCR. J Immunol 2008; 181: 4798–4806.
  Article CAS PubMed Google Scholar
• Gober HJ, Kistowska M, Angman L, Jeno P, Mori L, de Libero G . Human T cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells. J Exp Med 2003; 197: 163–168.
  Article CAS PubMed PubMed Central Google Scholar
• Thompson K, Rojas-Navea J, Rogers MJ . Alkylamines cause Vγ9Vδ2 T cell activation and proliferation by inhibiting the mevalonate pathway. Blood 2006; 107: 651–654.
  Article CAS PubMed Google Scholar
• Kunzmann V, Bauer E, Wilhelm M . γ/δ T-cell stimulation by pamidronate. New Engl J Med 1999; 340: 737–738.
  Article CAS PubMed Google Scholar
• Bukowski JF, Morita CT, Brenner MB . Human γδ T cells recognize alkylamines derived from microbes, edible plants, tea: implications for innate immunity. Immunity 1999; 11: 57–65.
  Article CAS PubMed Google Scholar
• Matsuura E, Lopez LR, Shoenfeld Y, Ames PRJ . β2 glycoprotein I and oxidative inflammation in early atherogenesis: a progression from innate to adaptive immunity? Autoimmun Rev; e-pub ahead of print 2012 Apr 27; doi: 10.1016/j.autrev.2012.04.003.
  Article CAS PubMed Google Scholar