Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba (Salvia Hispanica L.) (original) (raw)

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• Published: 20 January 2010

European Journal of Clinical Nutrition volume 64, pages 436–438 (2010)Cite this article

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Abstract

Despite strong correlations linking whole-grain consumption to reductions in heart disease, the physiological mechanisms involved remain ambiguous. We assessed whether Salba (Salvia Hispanica L.) whole grain reduces postprandial glycemia in healthy subjects, as a possible explanation for its cardioprotective effects observed in individuals with diabetes. The study used acute, randomized, double-blind, controlled design in which 11 healthy individuals (6 males and 5 females; body mass index 22.3±2.8 kg/m2) received 0, 7, 15 or 24 g of Salba baked into white bread. Capillary samples and appetite ratings were collected over 2 h after consumption. A dose-response reduction in postprandial glycemia (_P_=0.002, _r_2=0.203) was observed with all three doses of Salba, significantly decreasing incremental areas under the curve (iAUCs) and time point-specific blood glucose (P<0.05). Appetite ratings were decreased at 60 min after high, 90 min after high and intermediate and at 120 min after all treatments (P<0.05). Decrease in postprandial glycemia provides a potential explanation for improvements in blood pressure, coagulation and inflammatory markers previously observed after 12-week Salba supplementation in type II diabetes.

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Acknowledgements

Salba Smart Natural Products, Denver, CO, USA, provided Salba grain. The results were presented as an abstract at Experimental Biology 2008 (The FASEB Journal. 2008;22:305.6), supported by an unrestricted travel grant received from Salba Corporation S.A, Buenos Aires, Argentina.

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Authors and Affiliations

1. Clinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, Toronto, Ontario, Canada
   V Vuksan, A L Jenkins, A G Dias, A S Lee, E Jovanovski & A L Rogovik
2. Keenan Research Center of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada
   V Vuksan
3. Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
   V Vuksan, A G Dias & A S Lee
4. Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
   V Vuksan & A Hanna
5. Division of Endocrinology and Metabolism, St Michael's Hospital, Toronto, O, ntario, Canada
   V Vuksan & A Hanna

Authors

1. V Vuksan
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2. A L Jenkins
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3. A G Dias
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4. A S Lee
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5. E Jovanovski
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6. A L Rogovik
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7. A Hanna
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Correspondence toV Vuksan.

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Vuksan, V., Jenkins, A., Dias, A. et al. Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba (Salvia Hispanica L.).Eur J Clin Nutr 64, 436–438 (2010). https://doi.org/10.1038/ejcn.2009.159

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• Received: 28 July 2009
• Revised: 24 October 2009
• Accepted: 06 November 2009
• Published: 20 January 2010
• Issue Date: April 2010
• DOI: https://doi.org/10.1038/ejcn.2009.159