Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese (original) (raw)

Genes & Immunity volume 10, pages 219–226 (2009)Cite this article

Abstract

In this study, we compared the association of several newly discovered susceptibility genes for systemic lupus erythematosus (SLE) between populations of European origin and two Asian populations. Using 910 SLE patients and 1440 healthy controls from Chinese living in Hong Kong, and 278 SLE patients and 383 controls in Thailand, we studied association of STAT4, BLK and PXK with the disease. Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, _P_=3.55 × 10−23) and BLK (rs13277113, OR=0.77, _P_=1.34 × 10−5) with SLE. It was showed that rs7574865 of STAT4 is also linked to hematologic disorders and potentially some other subphenotypes of the disease. More than one genetic variant in STAT4 were found to be associated with the disease independently in our populations (rs7601754, OR=0.59, _P_=1.39 × 10−9, and _P_=0.00034 when controlling the effect of rs7574865). With the same set of samples, however, our study did not detect any significant disease association for PXK, a risk factor for populations of European origin (rs6445975, joint _P_=0.36, OR=1.06, 95% confidence interval: 0.93–1.21). Our study indicates that some of the susceptibility genes for this disease may be population specific.

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Acknowledgements

This study was partially supported by the Shun Tak District Min Yuen Tong of Hong Kong. PN and MZ were supported by Edward Sai Kim Hotung Paediatric Education and Research Fund, and University Postgraduate Studentship. WY acknowledges support from UGC, UHK (200711159155).

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Author notes

  1. C S Lau
    Present address: 8Current address: Division of Medicine & Therapeutics, Ninewells Hospital & Medical School, Dundee, DD1 9SY, Tayside, UK.,

Authors and Affiliations

  1. Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    W Yang, P Ng, M Zhao, T L Lee, M H K Ho, P P W Lee, W H S Wong & Y L Lau
  2. Department of Microbiology, Lupus Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    N Hirankarn
  3. Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    C S Lau, T M Chan, R W S Wong & M Y Mok
  4. Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    C C Mok
  5. Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China
    K W Lee
  6. Department of Paediatrics and Adolescent Medicine, Tuen Mun Hospital, Hong Kong, China
    S N Wong
  7. Department of Medicine, Lupus Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Y Avihingsanon

Authors

  1. W Yang
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  2. P Ng
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  3. M Zhao
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  4. N Hirankarn
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  5. C S Lau
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  6. C C Mok
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  7. T M Chan
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  8. R W S Wong
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  9. K W Lee
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  10. M Y Mok
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  11. S N Wong
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  12. Y Avihingsanon
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  13. T L Lee
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  14. M H K Ho
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  15. P P W Lee
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  16. W H S Wong
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  17. Y L Lau
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Correspondence toY L Lau.

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Supplementary Information accompanies the paper on Genes and Immunity website (http://www.nature.com/gene)

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Yang, W., Ng, P., Zhao, M. et al. Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese.Genes Immun 10, 219–226 (2009). https://doi.org/10.1038/gene.2009.1

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