Delivering multiple gene products in the brain from a single adeno-associated virus vector (original) (raw)
Shen Y, Muramatsu SI, Ikeguchi K, Fujimoto KI, Fan DS, Ogawa M et al. Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase for gene therapy of Parkinson's disease. Hum Gene Ther 2000; 11: 1509–1519. ArticleCAS Google Scholar
Hippenmeyer PJ, Krivi GG . Gene expression from heterologous promoters in a replication-defective avian retrovirus vector in quail cells. Poult Sci 1991; 70: 982–992. ArticleCAS Google Scholar
Nakajima K, Ikenaka K, Nakahira K, Morita N, Mikoshiba K . An improved retroviral vector for assaying promoter activity. Analysis of promoter interference in pIP211 vector. FEBS Lett 1993; 315: 129–133. ArticleCAS Google Scholar
Zaboikin MM, Schuening FG . Poor expression of MDR1 transgene in HeLa cells by bicistronic Moloney murine leukemia virus-based vector. Hum Gene Ther 1998; 9: 2263–2275. ArticleCAS Google Scholar
Mizuguchi H, Xu Z, Ishii-Watabe A, Uchida E, Hayakawa T . IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector. Mol Ther 2000; 1: 376–382. ArticleCAS Google Scholar
Thomas CL, Maule AJ . Limitations on the use of fused green fluorescent protein to investigate structure-function relationships for the cauliflower mosaic virus movement protein. J Gen Virol 2000; 81 (Pt 7): 1851–1855. ArticleCAS Google Scholar
Norman KR, Maricq AV . Innexin function: minding the gap junction. Curr Biol 2007; 17: R812–R814. ArticleCAS Google Scholar
Seidah NG, Chretien M . Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res 1999; 848: 45–62. ArticleCAS Google Scholar
Haberman RP, Samulski RJ, McCown TJ . Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion. Nat Med 2003; 9: 1076–1080. ArticleCAS Google Scholar
Holst JJ, Bersani M, Hvidberg A, Knigge U, Christiansen E, Madsbad S et al. On the effects of human galanin in man. Diabetologia 1993; 36: 653–657. ArticleCAS Google Scholar
McCown TJ . Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo. Mol Ther 2006; 14: 63–68. ArticleCAS Google Scholar
Muzzin P, Eisensmith RC, Copeland KC, Woo SL . Hepatic insulin gene expression as treatment for type 1 diabetes mellitus in rats. Mol Endocrinol 1997; 11: 833–837. ArticleCAS Google Scholar
Margaritis P, Arruda VR, Aljamali M, Camire RM, Schlachterman A, High KA . Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII. J Clin Invest 2004; 113: 1025–1031. ArticleCAS Google Scholar
Foti S, Haberman RP, Samulski RJ, McCown TJ . Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo. Gene Therapy 2007; 14: 1534–1536. ArticleCAS Google Scholar
Gäken J, Jiang J, Daniel K, van Berkel E, Hughes C, Kuiper M et al. Fusagene vectors: a novel strategy for the expression of multiple genes from a single cistron. Gene Therapy 2000; 7: 1979–1985. Article Google Scholar
Zeng G . Sticky-end PCR: new method for subcloning. Biotechniques 1998; 25: 206–208. ArticleCAS Google Scholar
Grieger JC, Choi VW, Samulski RJ . Production and characterization of adeno-associated viral vectors. Nat Protoc 2006; 1: 1412–1428. ArticleCAS Google Scholar
Rabinowitz JE, Rolling F, Li C, Conrath H, Xiao W, Xiao X et al. Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity. J Virol 2002; 76: 791–801. ArticleCAS Google Scholar
Paxinos G, Watson C . The Rat Brain in Stereotaxic Coordinates, 5th edn. Elsevier Academic Press: Burlington, MA, 2005. Google Scholar
Kamau SW, Grimm F, Hehl AB . Expression of green fluorescent protein as a marker for effects of antileishmanial compounds in vitro. Antimicrob Agents Chemother 2001; 45: 3654–3656. ArticleCAS Google Scholar
Racine RJ . Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972; 32: 281–294. ArticleCAS Google Scholar