Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans (original) (raw)

• Cannon B, Nedergaard J . Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84: 277–359.
  Article CAS PubMed Google Scholar
• Lowell BB, Spiegelman BM . Towards a molecular understanding of adaptive thermogenesis. Nature 2000; 404: 652–660.
  Article CAS PubMed Google Scholar
• Cohade C, Osman M, Pannu HK, Wahl RL . Uptake in supraclavicular area fat (‘USA-Fat’): description on 18F-FDG PET/CT. J Nucl Med 2003; 44: 170–176.
  CAS PubMed Google Scholar
• Nedergaard J, Bengtsson T, Cannon B . Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007; 293: E444–E452.
  Article CAS PubMed Google Scholar
• Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009; 360: 1518–1525.
  Article CAS PubMed Google Scholar
• Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, Cannon B et al. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 2009; 23: 3113–3120.
  Article CAS PubMed Google Scholar
• Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360: 1509–1517.
  Article CAS PubMed PubMed Central Google Scholar
• Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009; 58: 1526–1531.
  Article CAS PubMed PubMed Central Google Scholar
• van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009; 360: 1500–1508.
  CAS PubMed Google Scholar
• Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, Kawai Y et al. Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity 2011; 19: 13–16.
  Article PubMed Google Scholar
• Orava J, Nuutila P, Lidell ME, Oikonen V, Noponen T, Viljanen T et al. Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab 2011; 14: 272–279.
  Article CAS PubMed Google Scholar
• Yoneshiro T, Aita S, Matsushita M, Okamatsu-Ogura Y, Kameya T, Kawai Y et al. Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity 2011; 19: 1755–1760.
  Article PubMed Google Scholar
• Collins S, Yehuda-Shnaidman E, Wang H . Positive and negative control of ucp1 gene transcription and the role of β-adrenergic signaling networks. Int J Obes 2010; 34: S28–S33.
  Article CAS Google Scholar
• Oppert JM, Vohl MC, Chagnon M, Dionne FT, Cassard-Doulcier AM, Ricquier D et al. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat. Int J Obes 1994; 18: 526–531.
  CAS Google Scholar
• Jia JJ, Tian YB, Cao ZH, Tao LL, Zhang X, Gao SZ et al. The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes. Mol Biol Rep 2010; 37: 1513–1522.
  Article CAS PubMed Google Scholar
• Del Mar Gonzalez-Barroso M, Ricquier D, Cassard-Doulcier AM . The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research. Obes Rev 2000; 1: 61–72.
  Article CAS PubMed Google Scholar
• Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med 1995; 333: 343–347.
  Article CAS PubMed Google Scholar
• Arner P, Hoffstedt J . Adrenoceptor genes in human obesity. J Intern Med 1999; 245: 667–672.
  Article CAS PubMed Google Scholar
• Nagai N, Sakane N, Tsuzaki K, Moritani T . UCP1 genetic polymorphism (–3826 A/G) diminishes resting energy expenditure and thermoregulatory sympathetic nervous system activity in young females. Int J Obes 2011; 35: 1050–1055.
  Article CAS Google Scholar
• Valve R, Heikkinen S, Rissanen A, Laakso M, Uusitupa M . Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns. Diabetologia 1998; 41: 357–361.
  Article CAS PubMed Google Scholar
• Nagai N, Sakane N, Fujishita A, Fujiwara R, Kimura T, Kotani K et al. The −3826 A→G variant of the uncoupling protein-1 gene diminishes thermogenesis during acute cold exposure in healthy children. Obes Res Clin Pract 2007; 1: 99–107.
  Article Google Scholar
• Nagai N, Sakane N, Ueno LM, Hamada T, Moritani T . The −3826 A→G variant of the uncoupling protein-1 gene diminishes postprandial thermogenesis after a high fat meal in healthy boys. J Clin Endocrinol Metab 2003; 88: 5661–5667.
  Article CAS PubMed Google Scholar
• Kogure A, Yoshida T, Sakane N, Umekawa T, Takakura Y, Kondo M . Synergic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on weight loss in obese Japanese. Diabetologia 1998; 41: 1399.
  Article CAS PubMed Google Scholar
• Yoshida T, Sakane N, Umekawa T, Sakai M, Takahashi T, Kondo M . Mutation of beta 3-adrenergic-receptor gene and response to treatment of obesity. Lancet 1995; 25: 1433–1434.
  Article Google Scholar
• van der Kooy K, Seidell JC . Techniques for the measurement of visceral fat: a practical guide. Int J Obes 1993; 17: 187–196.
  CAS Google Scholar
• Rose G, Crocco P, D’Aquila P, Montesanto A, Bellizzi D, Passarino G . Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity. Exp Gerontol 2011; 46: 897–904.
  Article CAS PubMed Google Scholar
• Esterbauer H, Oberkofler H, Liu YM, Breban D, Hell E, Krempler F et al. Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus. J Lip Res 1998; 39: 834–844.
  CAS Google Scholar
• Lee P, Zhao JT, Swarbrick MM, Gracie G, Bova R, Greenfield JR et al. High prevalence of brown adipose tissue in adult humans. J Clin Endocrinol Metab 2011; 96: 2450–2455.
  Article CAS PubMed Google Scholar
• Florez-Duquet M, McDonald RB . Cold-induced thermoregulation and biological aging. Physiol Rev 1998; 78: 339–358.
  Article CAS PubMed Google Scholar
• Piétri-Rouxel F, John Manning B, Gros J, Strosberg AD . The biochemical effect of the naturally occurring Trp64→Arg mutation on human beta3-adrenoceptor activity. Eur J Biochem 1997; 247: 1174–1179.
  Article PubMed Google Scholar
• Heilbronn LK, Kind KL, Pancewicz E, Morris AM, Noakes M, Clifton PM . Association of −3826 G variant in uncoupling protein-1 with increased BMI in overweight Australian women. Diabetologia 2000; 43: 242–244.
  Article CAS PubMed Google Scholar
• Hayakawa T, Nagai Y, Taniguchi M, Yamashita H, Takamura T, Abe T et al. Phenotypic characterization of the beta3-adrenergic receptor mutation and the uncoupling protein 1 polymorphism in Japanese men. Metabolism 1999; 48: 636–640.
  Article CAS PubMed Google Scholar
• Urhammer SA, Hansen T, Borch-Johnsen K, Pedersen O . Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the −3826 A→G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects. J Clin Endocrinol Metab 2000; 85: 3151–3154.
  CAS PubMed Google Scholar
• Shihara N, Yasuda K, Moritani T, Ue H, Uno M, Adachi T et al. Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity. Int J Obes 2001; 25: 761–766.
  Article CAS Google Scholar
• Kurokawa N, Young EH, Oka Y, Satoh H, Wareham NJ, Sandhu MS et al. The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals. Int J Obes 2008; 32: 1240–1249.
  Article CAS Google Scholar