High-fat meal, systemic inflammation and glucose homeostasis in obese children and adolescents (original) (raw)

International Journal of Obesity volume 41, pages 986–989 (2017)Cite this article

Subjects

Abstract

We aimed to assess in obese youths the relationships between interleukin-6 (IL-6), fat meal-induced endotoxemia and glucose homeostasis. Twenty obese children/adolescents (9–17 years old, 11 boys) underwent a standard oral glucose tolerance test and, 7–14 days later, a 5-h fat meal test (fat=69% of energy, saturated/monounsaturated/polyunsaturated fatty acids=31.5%/35%/33.5%), with serial measures of IL-6 and two markers of lipopolysaccharide (LPS) exposure and translocation, LPS-binding protein (LBP) and soluble CD14 (sCD14). IL-6 correlated not only with basal (homeostatic model assessment-insulin resistance) but also with post-prandial (Matsuda index) insulin sensitivity (_r_=0.61 (0.24–0.82), _P_=0.005, _r_=−0.53 (0.12–0.78), _P_=0.03, respectively). IL-6 did not change after the meal whereas LBP and sCD14 decreased significantly, indicating LPS translocation. Neither basal sCD14 and LBP nor their incremental concentrations correlated with IL-6 or glucose homeostasis. In our sample, IL-6 was associated with insulin sensitivity but not with LPS exposure, suggesting that meals with a balanced content of saturated/monounsaturated/polyunsaturated fatty acids may not be associated with LPS-induced inflammation and metabolic impairment.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 print issues and online access

$259.00 per year

only $21.58 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1

Similar content being viewed by others

References

  1. Donath MY, Shoelson SE . Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011; 11: 98–107.
    Article CAS Google Scholar
  2. Kowalska I, Straczkowski M, Nikolajuk A, Adamska A, Karczewska-Kupczewska M . Insulin resistance, serum adiponectin, and pro-inflammatory markers in young subjects with the metabolic syndrome. Metabolism 2008; 57: 1539–1544.
    Article CAS Google Scholar
  3. Galcheva SV, Iotova VM, Yotov YT, Bernasconi S, Street ME . Circulating pro-inflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children. Eur J Endocrinol 2011; 164: 553–558.
    Article CAS Google Scholar
  4. De Filippo G, Rendina G, Moccia F, Rocco V, Campanozzi A . Interleukin-6, soluble interleukin-6 receptor/interleukin-6 complex and insulin resistance in obese children and adolescents. J Endocrinol Invest 2015; 38: 339–343.
    Article CAS Google Scholar
  5. Alvarez JA, Higgins PB, Oster RA, Fernandez JR, Darnell BE, Gower BA . Fasting and postprandial markers of inflammation in lean and overweight children. Am J Clin Nutr 2009; 89: 1138–1144.
    Article CAS Google Scholar
  6. Kabaroğlu C, Ersoy B, Onur E, Özhan B, Erdin S, Var A et al. Elevated glucose level at 30 minutes during an oral glucose tolerance test in obese adolescents: a new disorder of glucose tolerance. Endocr J 2013; 60: 197–205.
    Article Google Scholar
  7. Kayser BD, Toledo-Corral CM, Alderete TL, Weigensberg MJ, Goran MI . Temporal relationships between adipocytokines and diabetes risk in Hispanic adolescents with obesity. Obesity (Silver Spring) 2015; 23: 1479–1485.
    Article CAS Google Scholar
  8. Herieka M, Erridge C . High-fat meal induced postprandial inflammation. Mol Nutr Food Res 2014; 58: 136–146.
    Article CAS Google Scholar
  9. Vors C, Pineau G, Drai J, Meugnier E, Pesenti S, Laville M et al. Postprandial endotoxemia linked with chylomicrons and lipopolysaccharides handling in obese versus lean men: a lipid dose-effect trial. J Clin Endocr Metab 2015; 100: 3427–3435.
    Article CAS Google Scholar
  10. Erridge C, Attina T, Spickett CM, Webb DJ . A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 2007; 86: 1286–1292.
    Article CAS Google Scholar
  11. Kong LC, Holmes BA, Cotillard A, Habi-Rachedi F, Brazeilles R, Gougis S et al. Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects. PLoS One 2014; 9: e109434.
    Article Google Scholar
  12. Schauren BC, Portal VL, Beltrami FG, dos Santos TJ, Pellanda LC . Postprandial metabolism and inflammatory markers in overweight adolescents. J Dev Orig Health Dis 2014; 5: 299–306.
    Article CAS Google Scholar
  13. Mager DR, Mazurak V, Rodriguez-Dimitrescu C, Vine D, Jetha M, Ball G et al. A meal high in saturated fat evokes postprandial dyslipemia, hyperinsulinemia, and altered lipoprotein expression in obese children with and without nonalcoholic fatty liver disease. J Parenter Enteral Nutr 2013; 37: 517–528.
    Article CAS Google Scholar
  14. Maffeis C, Pinelli L, Surano MG, Fornari E, Cordioli S, Gasperotti S et al. Pro-atherogenic postprandial profile: meal-induced changes of lipoprotein sub-fractions and inflammation markers in obese boys. Nutr Metab Cardiovasc Dis 2012; 22: 959–965.
    Article CAS Google Scholar
  15. Morandi A, Miraglia Del Giudice E, Martino F, Martino E, Bozzola M, Maffeis C . Anthropometric indices are not satisfactory predictors of metabolic comorbidities in obese children and adolescents. J Pediatr 2014; 165: 1178–1183.
    Article Google Scholar
  16. Kabiri LS, Hernandez DC, Mitchell K . Reliability, validity, and diagnostic value of a pediatric bioelectrical impedance analysis scale. Child Obes 2015; 11: 650–655.
    Article Google Scholar
  17. Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Järvinen H, Van Haeften T et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 2000; 23: 295–301.
    Article CAS Google Scholar
  18. Retnakaran R, Shen S, Hanley AJ, Vuksan V, Hamilton JK, Zinman B . Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test. Obesity 2008; 16: 1901–1907.
    Article CAS Google Scholar
  19. Jiménez-Gómez Y, López-Miranda J, Blanco-Colio LM, Marín C, Pérez-Martínez P, Ruano J et al. Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men. Atherosclerosis 2009; 204: e70–e76.
    Article Google Scholar
  20. Papageorgiou N, Tousoulis D, Psaltopoulou T, Giolis A, Antoniades C, Tsiamis E et al. Divergent anti-inflammatory effects of different oil acute consumption on healthy individuals. Eur J Clin Nutr 2011; 65: 514–519.
    Article CAS Google Scholar

Download references

Acknowledgements

We are sincerely indebted to the children and adolescents who participated in the study and to their families. We thank the dedicated staff of the Pediatric Diabetes and Metabolic Disorders Unit of the University Hospital in Verona for their support during the clinical study.

Author information

Authors and Affiliations

  1. Department of Surgery, Pediatric Diabetes and Metabolic Disorders Unit, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy
    A Morandi, E Fornari, F Opri, M Corradi, M Tommasi & C Maffeis
  2. Division of Endocrinology, Department of Clinical and Experimental Medicine, University Hospital of Parma, Parma, Italy
    R Bonadonna

Authors

  1. A Morandi
    You can also search for this author inPubMed Google Scholar
  2. E Fornari
    You can also search for this author inPubMed Google Scholar
  3. F Opri
    You can also search for this author inPubMed Google Scholar
  4. M Corradi
    You can also search for this author inPubMed Google Scholar
  5. M Tommasi
    You can also search for this author inPubMed Google Scholar
  6. R Bonadonna
    You can also search for this author inPubMed Google Scholar
  7. C Maffeis
    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence toC Maffeis.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

About this article

Cite this article

Morandi, A., Fornari, E., Opri, F. et al. High-fat meal, systemic inflammation and glucose homeostasis in obese children and adolescents.Int J Obes 41, 986–989 (2017). https://doi.org/10.1038/ijo.2017.48

Download citation