Chemomicin A, a New Angucyclinone Antibiotic Produced by Nocardia mediterranei subsp. kanglensis 1747-64 (original) (raw)

The Journal of Antibiotics volume 60, pages 211–215 (2007) Cite this article

Abstract

A new angucyclinone antibiotic, chemomicin A was isolated from cultured broth of Nocardia mediterranei subsp. kanglensis 1747-64. Its chemical structure was determined to be 1,2,3,4a,5,6,6a,12a,12b-nonahydro-1,2,3,8,12,12b-hexahydroxy-3-methyl-6a,12a-epoxybenz[a]anthracen-4,7(12_H_)-dione by a detailed spectroscopic analysis. Chemomicin A had antimicrobial activity against Bacillus subtilis and Enterococcus faecium with MIC values of 10.2 and 20.4 μM, respectively, and showed cytotoxicity against human colorectal cancer HCT116 cells and human esophageal carcinoma YES-2 cells with IC50 values of 127 and 153 μM, respectively.

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References

  1. Li Q, Yao ZY, Yao NT, Li YY . Taxonomic study on the kanglemycin producing microorganism, Nocardia mediterranei kanglesis 1747-64. Chin J Antibiot 20: 246–248 ( 1995)
    Google Scholar
  2. Wang NJ, Yang XS, He CH . The structural elucidation of kanglemycin C. Chin J Antibiot 19: 86–90 ( 1994)
    CAS Google Scholar
  3. Sun CH, Wang NJ, Han BL . Isolation and structure determination of kanglemycin M, a new benz[a]anthraquinone antibiotic. Chin J Antibiot 21: 81–83 ( 1996)
    Google Scholar
  4. Rohr J, Thiericke R . Angucycline group antibiotics. Nat Prod Rep 9: 103–137 ( 1992)
    Article CAS Google Scholar
  5. Kern DL, Schaumberg JP, Hokanson GC, French JC . PD 116,779, a new antitumor antibiotic of the benz[a]anthraquinone class. J Antibiot 39: 469–470 ( 1986)
    Article CAS Google Scholar
  6. Puder C, Zeeck A, Beil W . New biologically active rubiginones from Streptomyces sp. J Antibiot 53: 329–336 ( 2000)
    Article CAS Google Scholar
  7. Tsukuda E, Tanaka T, Ochiai K, Kondo H, Yoshida M, Agatsuma T, Saitoh Y, Teshiba S, Matsuda Y . EI-1507-1 and -2, novel interleukin-1 beta converting enzyme inhibitors produced by Streptomyces sp. E-1507. J Antibiot 49: 333–339 ( 1996)
    Article CAS Google Scholar
  8. Igarashi M, Sasao C, Yoshida A, Naganawa H, Hamada M, Takeuchi T . Ochracenomicins A, B and C, new benz[a]anthraquinone antibiotics from Amicolatopsis sp. J Antibiot 48: 335–337 ( 1995)
    Article CAS Google Scholar
  9. Sasaki T, Gomi S, Sezaki M, Takeuchi Y, Kodama Y, Kawamura K . New antibiotics SF2315A and B produced by an Excellospora sp. II. The structural elucidation. J Antibiot 41: 843–848 ( 1988)
    Article CAS Google Scholar
  10. Hayakawa Y, Ha SC, Kim YJ, Furihata K, Seto H . Studies on the isotetracenone antibiotics. IV. Hatomarubigins A, B, C and D, new isotetracenone antibiotics effective against multidrug-resistant tumor cells. J Antibiot 44: 1179–1186 ( 1991)
    Article CAS Google Scholar
  11. Bringmann G, Lang G, Maksimenka K, Hamm A, Gulder TA, Dieter A, Bull AT, Stach JE, Kocher N, Muller WE, Fiedler HP . Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14. Phytochemistry 66: 1366–1373 ( 2005)
    Article CAS Google Scholar
  12. Sasaki T, Yoshida J, Itoh M, Gomi S, Shomura T, Sezaki M . New antibiotics SF2315A and B produced by an Excellospora sp. I. Taxonomy of the strain, isolation and characterization of antibiotics. J Antibiot 41: 835–842 ( 1988)
    Article CAS Google Scholar

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Author notes

  1. Cheng-Hang Sun and Yue Wang: These two authors have contributed equally to this work.

Authors and Affiliations

  1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, P.R. China
    Cheng-Hang Sun, Yue Wang, Jian-Qin Zhou, Wen-Zao Jin, Xue-Fu You, Hong Gao, Li-Xun Zhao & Shu-Yi Si
  2. Department of Pharmacy, Guilin Medical College, Guilin, 541004, P.R. China
    Zheng Wang
  3. BioScience College, Capital Normal University, Beijing, 100037, P.R. China
    Xue Li

Authors

  1. Cheng-Hang Sun
  2. Yue Wang
  3. Zheng Wang
  4. Jian-Qin Zhou
  5. Wen-Zao Jin
  6. Xue-Fu You
  7. Hong Gao
  8. Li-Xun Zhao
  9. Shu-Yi Si
  10. Xue Li

Corresponding author

Correspondence toCheng-Hang Sun.

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Sun, CH., Wang, Y., Wang, Z. et al. Chemomicin A, a New Angucyclinone Antibiotic Produced by Nocardia mediterranei subsp. kanglensis 1747-64.J Antibiot 60, 211–215 (2007). https://doi.org/10.1038/ja.2007.25

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