Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509 (original) (raw)

• Original Article
• Published: 01 April 2008

II. Physico-chemical Properties and Structure Elucidation

• Ryuji Uchida1 nAff3,
• Hitomi Yoshijima2,
• Hideaki Ui2,
• Kazuro Shiomi2,
• Yong-Pil Kim1,
• Tomoyasu Hirose1 nAff3,
• Toshiaki Sunazuka2,
• Akio Abe2,
• Hiroshi Tomoda2 &
• …
• Satoshi Ōmura1

The Journal of Antibiotics volume 61, pages 230–236 (2008) Cite this article

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Abstract

The structures of guadinomines, new inhibitors of a bacterial Type III secretion system produced by Streptomyces sp. K01-0509, were elucidated by spectroscopic studies including various NMR experiments. Guadinomines A, B, C1, C2 and D consist of a carbamoylated cyclic guanidinyl moiety, an alkyl chain moiety and an L-Ala-L-Val moiety in common, while guadinomic acid is a smaller molecule consisting of a carbamoylated cyclic guanidinyl moiety and a hydroxyl hexanoate moiety.

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Author notes

1. Ryuji Uchida & Tomoyasu Hirose
   Present address: School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

Authors and Affiliations

1. The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8642, Japan
   Masato Iwatsuki, Ryuji Uchida, Yong-Pil Kim, Tomoyasu Hirose & Satoshi Ōmura
2. Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan
   Hitomi Yoshijima, Hideaki Ui, Kazuro Shiomi, Toshiaki Sunazuka, Akio Abe & Hiroshi Tomoda

Authors

1. Masato Iwatsuki
2. Ryuji Uchida
3. Hitomi Yoshijima
4. Hideaki Ui
5. Kazuro Shiomi
6. Yong-Pil Kim
7. Tomoyasu Hirose
8. Toshiaki Sunazuka
9. Akio Abe
10. Hiroshi Tomoda
11. Satoshi Ōmura

Corresponding authors

Correspondence toHiroshi Tomoda or Satoshi Ōmura.

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Iwatsuki, M., Uchida, R., Yoshijima, H. et al. Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509.J Antibiot 61, 230–236 (2008). https://doi.org/10.1038/ja.2008.33

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• Received: 22 January 2008
• Accepted: 01 April 2008
• Issue date: 01 April 2008
• DOI: https://doi.org/10.1038/ja.2008.33

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