DNA copy-number abnormalities do not occur in infant ALL with t(4;11)/MLL-AF4 (original) (raw)

References

  1. Biondi A, Cimino G, Pieters R, Pui CH . Biological and therapeutic aspects of infant leukaemia. Blood 2000; 96: 24–33.
    CAS Google Scholar
  2. Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukaemia. Nat Genet 2002; 30: 41–47.
    Article CAS Google Scholar
  3. Pieters R, Schrappe M, De Lorenzo P, Hann I, De Rossi G, Felice M et al. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. Lancet 2007; 370: 198–200.
    Article Google Scholar
  4. Pui CH, Chessells JM, Camitta B, Baruchel A, Biondi A, Boyett JM et al. Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements. Leukemia 2003; 17: 700–706.
    Article CAS Google Scholar
  5. Hilden JM, Dinndorf PA, Meerbaum SO, Sather H, Villaluna D, Heerema NA et al. Analysis of prognostic factors of acute lymphoblastic leukemia in infants: report on CCG 1953 from the Children's Oncology Group. Blood 2006; 108: 441–451.
    Article CAS Google Scholar
  6. Tomizawa D, Koh K, Sato T, Kinukawa N, Morimoto A, Isoyama K et al. Outcome of risk-based therapy for infant acute lymphoblastic leukemia with or without an MLL gene rearrangement, with emphasis on late effects: a final report of two consecutive studies, MLL96 and MLL98, of the Japan Infant Leukemia Study Group. Leukemia 2007; 21: 2258–2263.
    Article CAS Google Scholar
  7. Ford AM, Ridge SA, Cabrera ME, Mahmoud H, Steel CM, Chan LC et al. In utero rearrangements in the trithorax-related oncogene in infant leukaemias. Nature 1993; 363: 358–360.
    Article CAS Google Scholar
  8. Greaves MF, Wiemels J . Origins of chromosome translocations in childhood leukaemia. Nature Rev Cancer 2003; 3: 639–649.
    Article CAS Google Scholar
  9. Metzler M, Forster A, Pannell R, Arends MJ, Daser A, Lobato MN et al. A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology. Oncogene 2006; 25: 3093–3103.
    Article CAS Google Scholar
  10. Chen W, Li Q, Hudson WA, Kumar A, Kirchhof N, Kersey JH . A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy. Blood 2006; 108: 669–677.
    Article CAS Google Scholar
  11. Ono R, Nakajima H, Ozaki K, Kumagai H, Kawashima T, Taki T et al. Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple lineage leukemogenesis. J Clin Invest 2005; 115: 919–929.
    Article CAS Google Scholar
  12. Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, Sinha AU et al. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell 2008; 14: 355–368.
    Article CAS Google Scholar
  13. Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007; 446: 758–764.
    Article CAS Google Scholar
  14. Kuiper RP, Schoenmakers EF, van Reijmersdal SV, Hehir-Kwa JY, van Kessel AG, van Leeuwen FN et al. High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia 2007; 21: 1258–1266.
    Article CAS Google Scholar
  15. Kawamata N, Ogawa S, Zimmermann M, Kato M, Sanada M, Hemminki K et al. Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high resolution single nucleotide polymorphism oligonucleotide genomic microarray. Blood 2008; 111: 776–784.
    Article CAS Google Scholar
  16. Paulsson K, Cazier JB, Macdougall F, Stevens J, Stasevich I, Vrcelj N et al. Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: unexpected similarities with pediatric disease. Proc Natl Acad Sci USA 2008; 105: 6708–6713.
    Article CAS Google Scholar
  17. Robinson WP . Mechanisms leading to uniparental disomy and their clinical consequences. Bioessays 2000; 22: 452–459.
    Article CAS Google Scholar
  18. Morison IM, Ellis LM, Teague LR, Reeve AE . Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukaemia. Blood 2002; 99: 375–377.
    Article CAS Google Scholar
  19. Raghavan M, Lillington DM, Skoulakis S, Debernardi S, Chaplin T, Foot NJ et al. Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemias. Cancer Res 2005; 65: 375–378.
    CAS Google Scholar
  20. Stephens K, Weaver M, Leppig KA, Maruyama K, Emanuel PD, Le Beau MM et al. Interstitial uniparental isodisomy at clustered breakpoint intervals is a frequent mechanism of NF1 inactivation in myeloid malignancies. Blood 2006; 108: 1684–1689.
    Article CAS Google Scholar
  21. Li LH, Ho SF, Chen CH, Wei CY, Wong WC, Li LY et al. Long contiguous stretches of homozygosity in the human genome. Hum Mutat 2006; 27: 1115–1121.
    Article CAS Google Scholar
  22. Gibson J, Morton NE, Collins A . Extended tracts of homozygosity in outbred human populations. Hum Mol Genet 2006; 15: 789–795.
    Article CAS Google Scholar
  23. Lencz T, Lambert C, DeRosse P, Burdick KE, Morgan TV, Kane JM et al. Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia. Proc Natl Acad Sci USA 2007; 104: 19942–19947.
    Article CAS Google Scholar
  24. Miyazawa H, Kato M, Awata T, Kohda M, Iwasa H, Koyama N et al. Homozygosity haplotype allows a genome-wide search for the autosomal segments shared among patients. Am J Hum Genet 2007; 80: 1090–1102.
    Article CAS Google Scholar
  25. Huqun, Izumi S, Miyazawa H, Ishii K, Uchiyama B, Ishida T et al. Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. Am J Respir Crit Care Med 2007; 175: 263–268.
    Article CAS Google Scholar
  26. Zangrando A, Dell’orto MC, Te Kronnie G, Basso G . MLL rearrangements in pediatric acute lymphoblastic and myeloblastic leukemias: MLL specific and lineage specific signatures. BMC Med Genomics 2009; 2: 36–47.
    Article Google Scholar
  27. Bungaro S, Dell’Orto MC, Zangrando A, Basso D, Gorletta T, Lo Nigro L et al. Integration of genomic and gene expression data of childhood ALL without known aberrations identifies subgroups with specific genetic hallmarks. Genes Chromosomes Cancer 2009; 48: 22–38.
    Article CAS Google Scholar
  28. Mullighan CG, Phillips LA, Su X, Ma J, Miller CB, Shurtleff SA et al. Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Science 2008; 322: 1377–1380.
    Article CAS Google Scholar
  29. Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL et al. Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. Genes Dev 2008; 22: 3403–3408.
    Article CAS Google Scholar

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