Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior (original) (raw)
Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders–Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. Morb Mortal Wkly Rep 2012; 61: 1–19. Google Scholar
Baron-Cohen S, Ring H, Moriarty J, Schmitz B, Costa D, Ell P. Recognition of mental state terms. Clinical findings in children with autism and a functional neuroimaging study of normal adults. Br J Psychiatry 1994; 165: 640–649. ArticleCAS Google Scholar
Castelli F, Frith C, Happé F, Frith U. Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain 2002; 125: 1839–1849. Article Google Scholar
Bachevalier J, Mishkin M. Visual recognition impairment follows ventromedial but not dorsolateral prefrontal lesions in monkeys. Behav Brain Res 1986; 20: 249–261. ArticleCAS Google Scholar
Morgan MA, Romanski LM, LeDoux JE. Extinction of emotional learning: contribution of medial prefrontal cortex. Neurosci Lett 1993; 163: 109–113. ArticleCAS Google Scholar
Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O’Shea DJ et al. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 2011; 477: 1–8. Article Google Scholar
Willsey AJ, Sanders SJ, Li M, Dong S, Tebbenkamp AT, Muhle RA et al. Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell 2013; 155: 997–1007. ArticleCAS Google Scholar
Happé F, Ehlers S, Fletcher P, Frith U, Johansson M, Gillberg C et al. ‘Theory of mind’ in the brain. Evidence from a PET scan study of Asperger syndrome. Neuroreport 1996; 8: 197–201. Article Google Scholar
Pierce K, Haist F, Sedaghat F, Courchesne E. The brain response to personally familiar faces in autism: findings of fusiform activity and beyond. Brain 2004; 127: 2703–2716. Article Google Scholar
Cheon KA, Kim YS, Oh SH, Park SY, Yoon HW, Herrington J et al. Involvement of the anterior thalamic radiation in boys with high functioning autism spectrum disorders: a Diffusion Tensor Imaging study. Brain Res 2011; 1417: 77–86. ArticleCAS Google Scholar
Nair A, Treiber JM, Shukla DK, Shih P, Müller R-A. Impaired thalamocortical connectivity in autism spectrum disorder: a study of functional and anatomical connectivity. Brain 2013; 136: 1942–1955. Article Google Scholar
Testa-Silva G, Loebel A, Giugliano M, de Kock CPJ, Mansvelder HD, Meredith RM. Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism. Cereb Cortex 2012; 22: 1333–1342. Article Google Scholar
Rinaldi T, Perrodin C, Markram H, Cauli B, Pierre U. Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic acid animal model of autism. Front Neural Circuits 2008; 2: 4. Article Google Scholar
Kalmbach BE, Johnston D, Brager DH. Cell-type specific channelopathies in the prefrontal cortex of the fmr1-/y mouse model of Fragile X syndrome. eNeuro 2015; 2, ENEURO.0114-15.2015.
Qiu S, Anderson CT, Levitt P, Shepherd GMG. Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase. J Neurosci 2011; 31: 5855–5864. ArticleCAS Google Scholar
Gee S, Ellwood I, Patel T, Luongo F, Deisseroth K, Sohal VS. Synaptic activity unmasks dopamine D2 receptor modulation of a specific class of layer V pyramidal neurons in prefrontal cortex. J Neurosci 2012; 32: 4959–4971. ArticleCAS Google Scholar
Lee AT, Gee SM, Vogt D, Patel T, Rubenstein JL, Sohal VS. Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition. Neuron 2014; 81: 61–68. ArticleCAS Google Scholar
Dembrow NC, Chitwood RA, Johnston D. Projection-specific neuromodulation of medial prefrontal cortex neurons. J Neurosci 2010; 30: 16922–16937. ArticleCAS Google Scholar
Seong HJ, Carter AG. D1 receptor modulation of action potential firing in a subpopulation of layer 5 pyramidal neurons in the prefrontal cortex. J. Neurosci 2012; 32: 10516–10521. ArticleCAS Google Scholar
Moore SJ, Turnpenny P, Quinn A, Glover S, Lloyd DJ, Montgomery T et al. A clinical study of 57 children with fetal anticonvulsant syndromes. J Med Genet 2000; 37: 489–497. ArticleCAS Google Scholar
Christensen J, Grønborg TK, Sørensen MJ, Schendel D, Parner ET, Pedersen LH et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 2013; 309: 1696–1703. ArticleCAS Google Scholar
Schneider T, Przewłocki R. Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism. Neuropsychopharmacology 2005; 30: 80–89. ArticleCAS Google Scholar
Strauss KA, Puffenberger EG, Huentelman MJ, Gottlieb S, Dobrin SE, Parod JM et al. Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2. N Engl J Med 2006; 354: 1370–1377. ArticleCAS Google Scholar
Verkerk A, Pieretti M, Sutcliffe J, Fu Y. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell 1991; 65: 905–914. ArticleCAS Google Scholar
Peñagarikano O, Abrahams BSS, Herman EII, Winden KDD, Gdalyahu A, Dong H et al. Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell 2011; 147: 235–246. Article Google Scholar
The Dutch-Belgian Fragile X Consortium. Fmr1 knockout mice: a model to study fragile X mental retardation. Cell 1994; 78: 23–33. Google Scholar
Spencer CM, Alekseyenko O, Serysheva E, Yuva-Paylor LA, Paylor R. Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome. Genes Brain Behav 2005; 4: 420–430. ArticleCAS Google Scholar
Murdoch JD, Gupta AR, Sanders SJ, Walker MF, Keaney J, Fernandez TV et al. No evidence for association of autism with rare heterozygous point mutations in contactin-associated protein-like 2 (CNTNAP2), or in other contactin-associated proteins or contactins. PLoS Genet 2015; 11: e1004852. Article Google Scholar
Gogolla N, Leblanc JJ, Quast KB, Südhof T, Fagiolini M, Hensch TK. Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord 2009; 1: 172–181. Article Google Scholar
Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A et al. Natural neural projection dynamics underlying social behavior. Cell 2014; 157: 1535–1551. ArticleCAS Google Scholar
Yona G, Meitav N, Kahn I, Shoham S. Realistic numerical and analytical modeling of light scattering in brain tissue for optogenetic applications. eNeuro 2016; 3, ENEURO.0059-15.2015.
Rinaldi T, Silberberg G, Markram H. Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid. Cereb Cortex 2008; 18: 763–770. Article Google Scholar
Zhang Y, Bonnan A, Bony G, Ferezou I, Pietropaolo S, Ginger M et al. Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1−/y mice. Nat Neurosci 2014; 17: 1701–1709. ArticleCAS Google Scholar
Shah MM. Hyperpolarization-activated cyclic nucleotide-gated channel currents in neurons. Cold Spring Harb Protoc 2016; 2016, pdb.top087346.
Yi F, Yi F, Danko T, Botelho SC, Patzke C, Pak C et al. Autism-associated SHANK3 haploinsufficiency causes I h channelopathy in human neurons. Science 2016; 352: 2669. Article Google Scholar
Adelsberger H, Garaschuk O, Konnerth A. Cortical calcium waves in resting newborn mice. Nat Neurosci 2005; 8: 988–990. ArticleCAS Google Scholar
Cui G, Jun SB, Jin X, Pham MD, Vogel SS, Lovinger DM et al. Concurrent activation of striatal direct and indirect pathways during action initiation. Nature 2013; 494: 238–242. ArticleCAS Google Scholar
Cui G, Jun SB, Jin X, Luo G, Pham MD, Lovinger DM et al. Deep brain optical measurements of cell type-specific neural activity in behaving mice. Nat Protoc 2014; 9: 1213–1228. ArticleCAS Google Scholar
Chen T-W, Wardill TJ, Sun Y, Pulver SR, Renninger SL, Baohan A et al. Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature 2013; 499: 295–300. ArticleCAS Google Scholar
Karlsson MP, Tervo DGR, Karpova AY. Network resets in medial prefrontal cortex mark the onset of behavioral uncertainty. Science 2012; 338: 135–139. ArticleCAS Google Scholar
Hyman JM, Ma L, Balaguer-Ballester E, Durstewitz D, Seamans JK. Contextual encoding by ensembles of medial prefrontal cortex neurons. Proc Natl Acad Sci USA 2012; 109: 5086–5091. ArticleCAS Google Scholar
Ma L, Hyman JM, Durstewitz D, Phillips AG, Seamans JK. A quantitative analysis of context-dependent remapping of medial frontal cortex neurons and ensembles. J Neurosci 2016; 36: 8258–8272. ArticleCAS Google Scholar
Tritsch NX, Sabatini BL. Dopaminergic modulation of synaptic transmission in cortex and striatum. Neuron 2012; 76: 33–50. ArticleCAS Google Scholar
Adhikari A, Lerner TN, Finkelstein J, Pak S, Jennings JH, Davidson TJ et al. Basomedial amygdala mediates top-down control of anxiety and fear. Nature 2015; 527: 179–185. ArticleCAS Google Scholar
Krettek JE, Price JL. The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat. J Comp Neurol 1977; 171: 157–191. ArticleCAS Google Scholar
Groenewegen HJ. Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography. Neuroscience 1988; 24: 379–431. ArticleCAS Google Scholar
Ray JP, Price JL. The organization of the thalamocortical connections of the mediodorsal thalamic nucleus in the rat, related to the ventral forebrain-prefrontal cortex topography. J Comp Neurol 1992; 323: 167–197. ArticleCAS Google Scholar
Ray JP, Price JL. The organization of projections from the mediodorsal nucleus of the thalamus to orbital and medial prefrontal cortex in macaque monkeys. J Comp Neurol 1993; 31: 1–31. Article Google Scholar
Goldman-Rakic PS, Porrino LJ. The primate mediodorsal (MD) nucleus and its projection to the frontal lobe. J Comp Neurol 1985; 242: 535–560. ArticleCAS Google Scholar
Conde F, Audinat E, Maire-Lepoivre E, Crepel F. Afferent connections of the medial frontal cortex of the rat. A study using retrograde transport of fluorescent dyes. I. Thalamic afferents. Brain Res Bull 1990; 24: 341–354. ArticleCAS Google Scholar
Parnaudeau S, Taylor K, Bolkan SS, Ward RD, Balsam PD, Kellendonk C. Mediodorsal thalamus hypofunction impairs flexible goal-directed behavior. Biol Psychiatry 2015; 77: 445–453. Article Google Scholar
Parnaudeau S, O’Neill P-K, Bolkan SS, Ward RD, Abbas AI, Roth BL et al. Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition. Neuron 2013; 77: 1151–1162. ArticleCAS Google Scholar
Bellebaum C, Daum I, Koch B, Schwarz M, Hoffmann KP. The role of the human thalamus in processing corollary discharge. Brain 2005; 128: 1139–1154. ArticleCAS Google Scholar
Crapse TB, Sommer MA. Corollary discharge across the animal kingdom. Nat Rev Neurosci 2008; 9: 587–600. ArticleCAS Google Scholar
Baxter MG. Mediodorsal thalamus and cognition in non-human primates. Front Syst Neurosci 2013; 7: 38. Article Google Scholar
Browning PGF, Chakraborty S, Mitchell AS. Evidence for mediodorsal thalamus and prefrontal cortex interactions during cognition in macaques. Cereb Cortex 2015; 25: 4519–4534. Article Google Scholar
Golden EC, Graff-Radford J, Jones DT, Benarroch EE. Mediodorsal nucleus and its multiple cognitive functions. Neurology 2016; 87: 2161–2168. Article Google Scholar
Tsatsanis KD, Rourke BP, Klin A, Volkmar FR, Cicchetti D, Schultz RT. Reduced thalamic volume in high-functioning individuals with autism. Biol Psychiatry 2003; 53: 121–129. Article Google Scholar
Tamura R, Kitamura H, Endo T, Hasegawa N, Someya T. Reduced thalamic volume observed across different subgroups of autism spectrum disorders. Psychiatry Res 2010; 184: 186–188. Article Google Scholar
Tan GCY, Doke TF, Ashburner J, Wood NW, Frackowiak RSJ. Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2. Neuroimage 2010; 53: 1030–1042. ArticleCAS Google Scholar
Rubenstein JLR, Merzenich MM. Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav 2003; 2: 255–267. ArticleCAS Google Scholar
Nelson SB, Valakh V. Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders. Neuron 2015; 87: 684–698. ArticleCAS Google Scholar
Gibson JR, Bartley AF, Hays Sa, Huber KM. Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome. J Neurophysiol 2008; 100: 2615–2626. Article Google Scholar
Dani VS, Chang Q, Maffei A, Turrigiano GG, Jaenisch R, Nelson SB. Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci USA 2005; 102: 12560–12565. ArticleCAS Google Scholar
Brager DH, Akhavan AR, Johnston D. Impaired dendritic expression and plasticity of h-channels in the fmr1-/y mouse model of Fragile X syndrome. Cell Rep 2012; 1: 225–233. ArticleCAS Google Scholar
Tyzio R, Nardou R, Ferrari DC, Tsintsadze T, Shahrokhi A, Eftekhari S et al. Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. Science 2014; 343: 675–679. ArticleCAS Google Scholar
Luongo FJ, Horn ME, Sohal VS. Putative microcircuit-level substrates for attention are disrupted in mouse models of autism. Biol Psychiatry 2016; 79: 667–675. Article Google Scholar