CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity (original) (raw)
el Hassan, A. M. et al. Post kala-azar dermal leishmaniasis in the Sudan: clinical features, pathology and treatment. Trans. R. Soc. Trop. Med. Hyg.86, 245–248 (1992) ArticleCASPubMed Google Scholar
Momeni, A. Z. & Aminjavaheri, M. Clinical picture of cutaneous leishmaniasis in Isfahan, Iran. Int. J. Dermatol.33, 260–265 (1994) ArticleCASPubMed Google Scholar
Shevach, E. M. CD4 + CD25 + suppressor T cells: more questions than answers. Nature Rev. Immunol.2, 389–400 (2002) ArticleCAS Google Scholar
Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol.155, 1151–1164 (1995) CASPubMed Google Scholar
Thornton, A. M. & Shevach, E. M. CD4 + CD25 + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med.188, 287–296 (1998) ArticleCASPubMedPubMed Central Google Scholar
Piccirillo, C. A. et al. CD4 + CD25 + regulatory T cells can mediate suppressor function in the absence of transforming growth factorβ1 production and responsivenes. J. Exp. Med.196, 237–246 (2002) ArticleCASPubMedPubMed Central Google Scholar
Papiernik, M., de Moraes, M. L., Pontoux, C., Vasseur, F. & Penit, C. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol.10, 371–378 (1998) ArticleCASPubMed Google Scholar
Belkaid, Y. et al. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J. Exp. Med.194, 1497–1506 (2001) ArticleCASPubMedPubMed Central Google Scholar
Belkaid, Y. et al. A natural model of Leishmania major infection reveals a prolonged ‘silent’ phase of parasite amplification in the skin before the onset of lesion formation and immunity. J. Immunol.165, 969–977 (2000) ArticleCASPubMed Google Scholar
Piccirillo, C. A. & Shevach, E. M. Cutting edge: control of CD8 + T cell activation by CD4 + CD25 + immunoregulatory cells. J. Immunol.167, 1137–1140 (2001) ArticleCASPubMed Google Scholar
Cederbom, L., Hall, H. & Ivars, F. CD4 + CD25 + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur. J. Immunol.30, 1538–1543 (2000) ArticleCASPubMed Google Scholar
Read, S., Malmstrom, V. & Powrie, F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation. J. Exp. Med.192, 295–302 (2000) ArticleCASPubMedPubMed Central Google Scholar
Gazzinelli, R. T., Oswald, I. P., James, S. L. & Sher, A. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ-activated macrophages. J. Immunol.148, 1792–1796 (1992) CASPubMed Google Scholar
Mendez, S. et al. The potency and durability of DNA- and protein-based vaccines against Leishmania major evaluated using low-dose, intradermal challenge. J. Immunol.166, 5122–5128 (2001) ArticleCASPubMed Google Scholar
Karp, C. L. et al. In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. J. Clin. Invest.91, 1644–1648 (1993) ArticleCASPubMedPubMed Central Google Scholar
Gasim, S. et al. High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis. Clin. Exp. Immunol.111, 64–69 (1998) ArticleCASPubMedPubMed Central Google Scholar
Powrie, F., Correa-Oliveira, R., Mauze, S. & Coffman, R. L. Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med.179, 589–600 (1994) ArticleCASPubMed Google Scholar
Gerosa, F. et al. CD4+ T cell clones producing both interferon-gamma and interleukin-10 predominate in bronchoalveolar lavages of active pulmonary tuberculosis patients. Clin. Immunol.92, 224–234 (1999) ArticleCASPubMed Google Scholar
Plebanski, M. et al. Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum. Immunity10, 651–660 (1999) ArticleCASPubMed Google Scholar
Jankovic, D. et al. In the absence of IL-12, CD4+ T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10-/- setting. Immunity16, 429–439 (2002) ArticleCASPubMed Google Scholar
Ostrowski, M. A. et al. Quantitative and qualitative assessment of human immunodeficiency virus type 1 (HIV-1)-specific CD4 + T cell immunity to gag in HIV-1-infected individuals with differential disease progression: reciprocal interferon-gamma and interleukin-10 responses. J. Infect. Dis.184, 1268–1278 (2001) ArticleCASPubMed Google Scholar
Uzonna, J. E., Wei, G., Yurkowski, D. & Bretscher, P. Immune elimination of Leishmania major in mice: implications for immune memory, vaccination, and reactivation disease. J. Immunol.167, 6967–6974 (2001) ArticleCASPubMed Google Scholar
O'Farrell, A. M., Liu, Y., Moore, K. W. & Mui, A. L. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J.17, 1006–1018 (1998) ArticleCASPubMedPubMed Central Google Scholar
von Stebut, E., Belkaid, Y., Jakob, T., Sacks, D. L. & Udey, M. C. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity. J. Exp. Med.188, 1547–1552 (1998) ArticleCASPubMedPubMed Central Google Scholar
Lutz, M. B. et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods223, 77–92 (1999) ArticleCASPubMed Google Scholar