Insights into IgA-mediated immune responses from the crystal structures of human FcαRI and its complex with IgA1-Fc (original) (raw)

• Monteiro, R. C. & Van De Winkel, J. G. IgA Fc receptors. Annu. Rev. Immunol. 21, 177–204 (2003)
  Article CAS Google Scholar
• Brandtzaeg, P. et al. Regional specialization in the mucosal immune system: what happens in the microcompartments? Immunol. Today 20, 141–151 (1999)
  Article CAS Google Scholar
• Norderhaug, I. N., Johansen, F. E., Schjerven, H. & Brandtzaeg, P. Regulation of the formation and external transport of secretory immunoglobulins. Crit. Rev. Immunol. 19, 481–508 (1999)
  CAS PubMed Google Scholar
• Monteiro, R. C., Kubagawa, H. & Cooper, M. D. Cellular distribution, regulation, and biochemical nature of an Fcα receptor in humans. J. Exp. Med. 171, 597–613 (1990)
  Article CAS Google Scholar
• Vidarsson, G. et al. Activity of human IgG and IgA subclasses in immune defense against Neisseria meningitidis serogroup B. J. Immunol. 166, 6250–6256 (2001)
  Article CAS Google Scholar
• van Egmond, M. et al. FcαRI-positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity. Nature Med. 6, 680–685 (2000)
  Article CAS Google Scholar
• van Spriel, A. B. et al. Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation. Blood 97, 2478–2486 (2001)
  Article CAS Google Scholar
• Motegi, Y. & Kita, H. Interaction with secretory component stimulates effector functions of human eosinophils but not of neutrophils. J. Immunol. 161, 4340–4346 (1998)
  CAS PubMed Google Scholar
• Wende, H., Colonna, M., Ziegler, A. & Volz, A. Organization of the leukocyte receptor cluster (LRC) on human chromosome 19q13.4. Mamm. Genome 10, 154–160 (1999)
  Article CAS Google Scholar
• Garman, S. C., Wurzburg, B. A., Tarchevskaya, S. S., Kinet, J. P. & Jardetzky, T. S. Structure of the Fc fragment of human IgE bound to its high-affinity receptor FcɛRIα. Nature 406, 259–266 (2000)
  Article ADS CAS Google Scholar
• Sondermann, P., Huber, R., Oosthuizen, V. & Jacob, U. The 3.2-Å crystal structure of the human IgG1 Fc fragment-FcγRIII complex. Nature 406, 267–273 (2000)
  Article ADS CAS Google Scholar
• Herr, A. B., White, C. L., Milburn, C., Wu, C. & Bjorkman, P. J. Bivalent binding of IgA1 to FcαRI suggests a mechanism for cytokine activation of IgA phagocytosis. J. Mol. Biol. 327, 645–657 (2003)
  Article CAS Google Scholar
• Pleass, R. J., Dunlop, J. I., Anderson, C. M. & Woof, J. M. Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human Fcα receptor (FcαR) CD89. J. Biol. Chem. 274, 23508–23514 (1999)
  Article CAS Google Scholar
• Carayannopoulos, L., Hexham, J. M. & Capra, J. D. Localization of the binding site for the monocyte immunoglobulin (Ig) A-Fc receptor (CD89) to the domain boundary between Cα2 and Cα3 in human IgA1. J. Exp. Med. 183, 1579–1586 (1996)
  Article CAS Google Scholar
• Martin, W. L., West, A. P. Jr, Gan, L. & Bjorkman, P. J. Crystal structure at 2.8 Å of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding. Mol. Cell 7, 867–877 (2001)
  Article CAS Google Scholar
• Chapman, T. L., Heikema, A. P., West, A. P. & Bjorkman, P. J. Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). Immunity 13, 727–736 (2000)
  Article CAS Google Scholar
• Garman, S. C., Kinet, J. P. & Jardetzky, T. S. Crystal structure of the human high-affinity IgE receptor. Cell 95, 951–961 (1998)
  Article CAS Google Scholar
• Maxwell, K. F. et al. Crystal structure of the human leukocyte Fc receptor, FcγRIIa. Nature Struct. Biol. 6, 437–442 (1999)
  Article CAS Google Scholar
• Sondermann, P., Huber, R. & Jacob, U. Crystal structure of the soluble form of the human Fcγ-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 Å resolution. EMBO J. 18, 1095–1103 (1999)
  Article CAS Google Scholar
• Fan, Q. R. et al. Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. Nature 389, 96–100 (1997)
  Article ADS CAS Google Scholar
• Huber, R., Deisenhofer, J., Colman, P. M., Matsushima, M. & Palm, W. Crystallographic structure studies of an IgG molecule and an Fc fragment. Nature 264, 415–420 (1976)
  Article ADS CAS Google Scholar
• Wan, T. et al. The crystal structure of IgE Fc reveals an asymmetrically bent conformation. Nature Immunol. 3, 681–686 (2002)
  Article CAS Google Scholar
• Wurzburg, B. A., Garman, S. C. & Jardetzky, T. S. Structure of the human IgE-Fc Cɛ3-Cɛ4 reveals conformational flexibility in the antibody effector domains. Immunity 13, 375–385 (2000)
  Article CAS Google Scholar
• Putnam, F. W., Liu, Y. S. & Low, T. L. Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the α1 heavy chain. J. Biol. Chem. 254, 2865–2874 (1979)
  CAS PubMed Google Scholar
• Yang, C., Kratzin, H., Gotz, H. & Hilschmann, N. Rule of antibody structure. Primary structure of a human monoclonal IgA-immunoglobulin (myeloma protein Tro). VII. Purification and characterization of the disulfide bridges. Hoppe-Seyler's Z. Physiol. Chem. 360, 1919–1940 (1979)
  CAS PubMed Google Scholar
• Morton, H. C. et al. Immunoglobulin-binding sites of human FcαRI (CD89) and bovine Fcγ2R are located in their membrane-distal extracellular domains. J. Exp. Med. 189, 1715–1722 (1999)
  Article CAS Google Scholar
• Wines, B. D. et al. Identification of residues in the first domain of human Fcα receptor essential for interaction with IgA. J. Immunol. 162, 2146–2153 (1999)
  CAS PubMed Google Scholar
• Wines, B. D., Sardjono, C. T., Trist, H. M., Lay, C. S. & Hogarth, P. M. The interaction of FcαRI with IgA and its implications for ligand binding by immunoreceptors of the leukocyte receptor cluster. J. Immunol. 166, 1781–1789 (2001)
  Article CAS Google Scholar
• Garman, S. C., Sechi, S., Kinet, J. P. & Jardetzky, T. S. The analysis of the human high affinity IgE receptor FcɛRIα from multiple crystal forms. J. Mol. Biol. 311, 1049–1062 (2001)
  Article CAS Google Scholar
• Deisenhofer, J. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-Å resolution. Biochemistry 20, 2361–2370 (1981)
  Article CAS Google Scholar
• Sauer-Eriksson, A. E., Kleywegt, G. J., Uhlen, M. & Jones, T. A. Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc domain of human IgG. Structure 3, 265–278 (1995)
  Article CAS Google Scholar
• Corper, A. L. et al. Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody–antigen interaction. Nature Struct. Biol. 4, 374–381 (1997)
  Article CAS Google Scholar
• DeLano, W. L., Ultsch, M. H., de Vos, A. M. & Wells, J. A. Convergent solutions to binding at a protein–protein interface. Science 287, 1279–1283 (2000)
  Article ADS CAS Google Scholar
• Saphire, E. O. et al. Contrasting IgG structures reveal extreme asymmetry and flexibility. J. Mol. Biol. 319, 9–18 (2002)
  Article CAS Google Scholar
• Shogren, R., Gerken, T. A. & Jentoft, N. Role of glycosylation on the conformation and chain dimensions of _O_-linked glycoproteins: light-scattering studies of ovine submaxillary mucin. Biochemistry 28, 5525–5536 (1989)
  Article CAS Google Scholar
• Iikura, M. et al. Secretory IgA induces degranulation of IL-3-primed basophils. J. Immunol. 161, 1510–1515 (1998)
  CAS PubMed Google Scholar
• Hexham, J. M. et al. A human immunoglobulin (Ig)A Cα3 domain motif directs polymeric Ig receptor-mediated secretion. J. Exp. Med. 189, 747–752 (1999)
  Article CAS Google Scholar
• White, K. D. & Capra, J. D. Targeting mucosal sites by polymeric immunoglobulin receptor-directed peptides. J. Exp. Med. 196, 551–555 (2002)
  Article CAS Google Scholar
• Bracke, M., Lammers, J. W., Coffer, P. J. & Koenderman, L. Cytokine-induced inside-out activation of FcαR (CD89) is mediated by a single serine residue (S263) in the intracellular domain of the receptor. Blood 97, 3478–3483 (2001)
  Article CAS Google Scholar
• Weisbart, R. H., Kacena, A., Schuh, A. & Golde, D. W. GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism. Nature 332, 647–648 (1988)
  Article ADS CAS Google Scholar
• Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307–326 (1997)
  Article CAS Google Scholar
• Terwilliger, T. C. & Berendzen, J. Automated MAD and MIR structure solution. Acta Crystallogr. D 55, 849–861 (1999)
  Article CAS Google Scholar
• De La Fortelle, E. & Bricogne, G. Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods. Methods Enzymol. 276, 472–494 (1997)
  Article CAS Google Scholar
• Collaborative Computational Project No. 4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760–763 (1994)
  Article Google Scholar
• Brunger, A. T. et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905–921 (1998)
  Article CAS Google Scholar
• Navaza, J. AMoRe: an automated package for molecular replacement. Acta Crystallogr. A 50, 157–163 (1994)
  Article Google Scholar
• McDonald, I. K. & Thornton, J. M. Satisfying hydrogen bonding potential in proteins. J. Mol. Biol. 238, 777–793 (1994)
  Article CAS Google Scholar
• Su, X. D. et al. Crystal structure of hemolin: a horseshoe shape with implications for homophilic adhesion. Science 281, 991–995 (1998)
  Article ADS CAS Google Scholar
• Kraulis, P. J. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24, 946–950 (1991)
  Article Google Scholar
• Merritt, E. A. & Murphy, M. E. P. Raster3D Version 2.0, a program for photorealistic molecular graphics. Acta Crystallogr. D 50, 869–873 (1994)
  Article CAS Google Scholar