Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex (original) (raw)

• Nakayama, K. I., Hatakeyama, S. & Nakayama, K. Regulation of the cell cycle at the G1–S transition by proteolysis of cyclin E and p27Kip1. Biochem. Biophys. Res. Commun. 282, 853–860 (2001)
  Article CAS Google Scholar
• Peters, J. M. The anaphase-promoting complex. Proteolysis in mitosis and beyond. Mol. Cell 9, 931–943 (2002)
  Article CAS Google Scholar
• Harper, J. W., Burton, J. L. & Solomon, M. J. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 16, 2179–2206 (2002)
  Article CAS Google Scholar
• Zhang, H., Kobayashi, R., Galaktionov, K. & Beach, D. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 82, 915–925 (1995)
  Article CAS Google Scholar
• Imaki, H. et al. Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein. Cancer Res. 63, 4607–4613 (2003)
  CAS PubMed Google Scholar
• Wirbelauer, C. et al. The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J. 19, 5362–5375 (2000)
  Article CAS Google Scholar
• Zachariae, W. & Nasmyth, K. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13, 2039–2058 (1999)
  Article CAS Google Scholar
• Schwab, M., Neutzner, M., Mocker, D. & Seufert, W. Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC. EMBO J. 20, 5165–5175 (2001)
  Article CAS Google Scholar
• McGarry, T. J. & Kirschner, M. W. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93, 1043–1053 (1998)
  Article CAS Google Scholar
• Fang, G., Yu, H. & Kirschner, M. W. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol. Cell 2, 163–171 (1998)
  Article CAS Google Scholar
• Pfleger, C. M., Lee, E. & Kirschner, M. W. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes Dev. 15, 2396–2407 (2001)
  Article CAS Google Scholar
• Sorensen, C. S. et al. Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis. Mol. Cell. Biol. 20, 7613–7623 (2000)
  Article CAS Google Scholar
• Nakayama, K. et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19, 2069–2081 (2000)
  Article CAS Google Scholar
• von der Lehr, N. et al. The F-box protein Skp2 participates in c-Myc proteasomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol. Cell 11, 1189–1200 (2003)
  Article CAS Google Scholar
• Kim, S. Y., Herbst, A., Tworkowski, K. A., Salghetti, S. E. & Tansey, W. P. Skp2 regulates Myc protein stability and activity. Mol. Cell 11, 1177–1188 (2003)
  Article CAS Google Scholar
• Sutterluty, H. et al. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nature Cell Biol. 1, 207–214 (1999)
  Article CAS Google Scholar
• Latres, E. et al. Role of the F-box protein Skp2 in lymphomagenesis. Proc. Natl Acad. Sci. USA 98, 2515–2520 (2001)
  Article ADS CAS Google Scholar
• Nelsen, C. J. et al. Induction of hepatocyte proliferation and liver hyperplasia by the targeted expression of cyclin E and skp2. Oncogene 20, 1825–1831 (2001)
  Article CAS Google Scholar
• Gstaiger, M. et al. Skp2 is oncogenic and overexpressed in human cancers. Proc. Natl Acad. Sci. USA 98, 5043–5048 (2001)
  Article ADS CAS Google Scholar
• Bloom, J. & Pagano, M. Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin. Cancer Biol. 13, 41–47 (2003)
  Article CAS Google Scholar
• Bashir, T., Dorrello, N., Amador, V., Guardavaccaro, D. & Pagano, M. Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase. Nature 428, 190–193 (2004)
  Article ADS CAS Google Scholar
• Murray, A. W. & Kirschner, M. W. Dominoes and clocks: the union of two views of the cell cycle. Science 246, 614–621 (1989)
  Article ADS CAS Google Scholar
• Ayad, N. G. et al. Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell 113, 101–113 (2003)
  Article CAS Google Scholar
• Sorensen, C. S. et al. A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression. Mol. Cell. Biol. 21, 3692–3703 (2001)
  Article CAS Google Scholar
• Kaelin, W. G., Pallas, D. C., DeCaprio, J. A., Kaye, F. J. & Livingston, D. M. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell 64, 521–532 (1991)
  Article CAS Google Scholar
• Wan, Y., Liu, X. & Kirschner, M. W. The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction. Mol. Cell 8, 1027–1039 (2001)
  Article CAS Google Scholar
• Pfleger, C. M. & Kirschner, M. W. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 14, 655–665 (2000)
  CAS PubMed PubMed Central Google Scholar
• Murray, A. Cell cycle extracts. Methods Cell Biol. 36, 581–605 (1991)
  Article CAS Google Scholar
• Brummelkamp, T. R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550–553 (2002)
  Article ADS CAS Google Scholar
• Mendez, J. et al. Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Mol. Cell 9, 481–491 (2002)
  Article CAS Google Scholar