Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA (original) (raw)

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Acknowledgements

We thank those who made possible the collection of blood samples for the study, in particular the patients and staff at Cato Manor Clinic and Sinikithemba Clinic, Durban, South Africa. We also thank S. McAdam, J. Webster and R. Phillips for comments and suggestions. This work was supported by a contract from the National Institutes of Health (B.D.W.), with additional support from the Wellcome Trust (P.J.R.G., A.J.L., P.Z., P.K.), the Elizabeth Glaser Pediatric AIDS Foundation (P.J.R.G., B.T.K.), the National Institutes of Health and the Doris Duke Charitable Foundation. P.J.R.G. and B.T.K. are Elizabeth Glaser Pediatric AIDS Foundation Scientists, B.D.W. is a Doris Duke Distinguished Science Professor.

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Authors and Affiliations

1. HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa
   Photini Kiepiela, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Hoosen M. Coovadia, Bruce D. Walker & Philip J. R. Goulder
2. Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK
   Alasdair J. Leslie, Isobella Honeyborne, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Cheryl Day, Paul Klenerman & Philip J. R. Goulder
3. Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, Western Australia, 6000, Australia
   Corey Moore, Ian James & Simon Mallal
4. Department of Microbiology, University of Washington, Seattle, Washington, 98195-8070, USA
   Sarah Moore & James Mullins
5. Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA
   Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Bruce D. Walker & Philip J. R. Goulder
6. Dynal Biotech Ltd, 11 Bassendale Road, Wirral, CH62 3QL, UK
   Michael Bunce
7. Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, NW3 2QG, London, UK
   Linda D. Barber
8. Santa Fe Institute, Santa Fe, New Mexico, 87501, USA
   James Szinger & Bette Korber
9. Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA
   James Szinger & Bette Korber
10. Howard Hughes Medical Institute, Chevy Chase, Maryland, 20815, USA
    Bruce D. Walker

Authors

1. Photini Kiepiela
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2. Alasdair J. Leslie
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3. Isobella Honeyborne
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4. Danni Ramduth
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5. Christina Thobakgale
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6. Senica Chetty
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7. Prinisha Rathnavalu
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8. Corey Moore
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9. Katja J. Pfafferott
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10. Louise Hilton
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11. Peter Zimbwa
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12. Sarah Moore
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13. Todd Allen
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14. Christian Brander
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15. Marylyn M. Addo
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16. Marcus Altfeld
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17. Ian James
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18. Simon Mallal
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19. Michael Bunce
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20. Linda D. Barber
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21. James Szinger
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22. Cheryl Day
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23. Paul Klenerman
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24. James Mullins
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25. Bette Korber
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26. Hoosen M. Coovadia
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27. Bruce D. Walker
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28. Philip J. R. Goulder
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Corresponding author

Correspondence toPhilip J. R. Goulder.

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Kiepiela, P., Leslie, A., Honeyborne, I. et al. Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.Nature 432, 769–775 (2004). https://doi.org/10.1038/nature03113

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• Received: 14 August 2004
• Accepted: 14 October 2004
• Issue Date: 09 December 2004
• DOI: https://doi.org/10.1038/nature03113