Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability (original) (raw)

• Bissell, M. J. & Radisky, D. Putting tumours in context. Nature Rev. Cancer 1, 46–54 (2001)
  Article CAS Google Scholar
• Sternlicht, M. D. & Werb, Z. How matrix metalloproteinases regulate cell behaviour. Annu. Rev. Cell Dev. Biol. 17, 463–516 (2001)
  Article CAS Google Scholar
• Sternlicht, M. D. et al. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell 98, 137–146 (1999)
  Article CAS Google Scholar
• Lochter, A. et al. Misregulation of stromelysin-1 expression in mouse mammary tumour cells accompanies acquisition of stromelysin-1-dependent invasive properties. J. Biol. Chem. 272, 5007–5015 (1997)
  Article CAS Google Scholar
• Lochter, A. et al. Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. J. Cell Biol. 139, 1861–1872 (1997)
  Article CAS Google Scholar
• Egeblad, M. & Werb, Z. New functions for the matrix metalloproteinases in cancer progression. Nature Rev. Cancer 2, 161–174 (2002)
  Article CAS Google Scholar
• Boudreau, N., Sympson, C. J., Werb, Z. & Bissell, M. J. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267, 891–893 (1995)
  Article ADS CAS Google Scholar
• Jordan, P., Brazao, R., Boavida, M. G., Gespach, C. & Chastre, E. Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors. Oncogene 18, 6835–6839 (1999)
  Article CAS Google Scholar
• Schnelzer, A. et al. Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene 19, 3013–3020 (2000)
  Article CAS Google Scholar
• Singh, A. et al. Rac1b, a tumour associated, constitutively active Rac1 splice variant, promotes cellular transformation. Oncogene 23, 9369–9380 (2004)
  Article CAS Google Scholar
• Kheradmand, F., Werner, E., Tremble, P., Symons, M. & Werb, Z. Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Science 280, 898–902 (1998)
  Article ADS CAS Google Scholar
• Werner, E. & Werb, Z. Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J. Cell Biol. 158, 357–368 (2002)
  Article CAS Google Scholar
• Samper, E., Nicholls, D. G. & Melov, S. Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts. Aging Cell 2, 277–285 (2003)
  Article CAS Google Scholar
• Suh, Y. A. et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature 401, 79–82 (1999)
  Article ADS CAS Google Scholar
• Droge, W. Free radicals in the physiological control of cell function. Physiol. Rev. 82, 47–95 (2002)
  Article CAS Google Scholar
• Puri, P. L. et al. A myogenic differentiation checkpoint activated by genotoxic stress. Nature Genet. 32, 585–593 (2002)
  Article CAS Google Scholar
• Finkel, T. Oxidant signals and oxidative stress. Curr. Opin. Cell Biol. 15, 247–254 (2003)
  Article CAS Google Scholar
• Madesh, M. & Hajnoczky, G. VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J. Cell Biol. 155, 1003–1015 (2001)
  Article CAS Google Scholar
• Mori, K., Shibanuma, M. & Nose, K. Invasive potential induced under long-term oxidative stress in mammary epithelial cells. Cancer Res. 64, 7464–7472 (2004)
  Article CAS Google Scholar
• Kalluri, R. & Neilson, E. G. Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112, 1776–1784 (2003)
  Article CAS Google Scholar
• Nieto, M. A. The snail superfamily of zinc-finger transcription factors. Nature Rev. Mol. Cell Biol. 3, 155–166 (2002)
  Article CAS Google Scholar
• Thiery, J. P. Epithelial-mesenchymal transitions in tumour progression. Nature Rev. Cancer 2, 442–454 (2002)
  Article CAS Google Scholar
• Struthers, L., Patel, R., Clark, J. & Thomas, S. Direct detection of 8-oxodeoxyguanosine and 8-oxoguanine by avidin and its analogues. Anal. Biochem. 255, 20–31 (1998)
  Article CAS Google Scholar
• Johnson, R. K., Inouye, T., Goldin, A. & Stark, G. R. Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase. Cancer Res. 36, 2720–2725 (1976)
  CAS PubMed Google Scholar
• Wahl, G. M., Padgett, R. A. & Stark, G. R. Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells. J. Biol. Chem. 254, 8679–8689 (1979)
  CAS PubMed Google Scholar
• Shin, C. & Manley, J. L. Cell signalling and the control of pre-mRNA splicing. Nature Rev. Mol. Cell Biol. 5, 727–738 (2004)
  Article CAS Google Scholar
• Matos, P., Collard, J. G. & Jordan, P. Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signalling. J. Biol. Chem. 278, 50442–50448 (2003)
  Article CAS Google Scholar
• Fiegen, D. et al. Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase. J. Biol. Chem. 279, 4743–4749 (2004)
  Article CAS Google Scholar
• Neumann, C. A. et al. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 424, 561–565 (2003)
  Article ADS CAS Google Scholar
• Snijders, A. M. et al. Shaping of tumour and drug-resistant genomes by instability and selection. Oncogene 22, 4370–4379 (2003)
  Article CAS Google Scholar